Term
| what type of receptors are Histamine receptors? how manya re there? |
|
Definition
metabotropic - G-protein
4 known |
|
|
Term
|
Definition
sedatives
allergic rhinitis - stuffy nose |
|
|
Term
|
Definition
Gastric ulcers
all end in "-tidine" |
|
|
Term
|
Definition
|
|
Term
| 1st generation H1 Blockers, describe, 4 types |
|
Definition
Nonselective - also bind alpha adrenergic and muscarinic receptors
CNS penetration -> sedation
Short t1/2
Alkylamines, ethanolamines, phenothiazines, piperazines |
|
|
Term
| 2nd generation H1 blockers |
|
Definition
Selective H1 blockers
limited/no CNS penetration - no sedation
CYP metabolized - interferes w/ other drugs
Intermediate t1/2 |
|
|
Term
| 3rd generation H1 blockers |
|
Definition
Selective H1 blocker
No CNS penetration
Not CYP metabolized
logn t1/2
H-receptor independent anti-inflammatory action |
|
|
Term
|
Definition
1st generation H1 blocker
alkylamine |
|
|
Term
|
Definition
1st generation H1 blocker
ethanolamine |
|
|
Term
|
Definition
1st genration H1 blocker
ethanolamine |
|
|
Term
|
Definition
1st generation H1 blocker
used in "coast guard cocktail"
phenothiazine |
|
|
Term
|
Definition
1st generation H1 blocker
piperazine |
|
|
Term
|
Definition
1st generation H1 blocker
piperazine |
|
|
Term
|
Definition
| 2nd generation H1 blocker |
|
|
Term
|
Definition
| 2nd generation H1 blocker prodrug - CYP 3A4 -> fexofenadine |
|
|
Term
|
Definition
| 2nd generation H1 blocker |
|
|
Term
|
Definition
| 2nd generation H1 blocker prodrug -CYP 3A4 -> Carebastin |
|
|
Term
|
Definition
| 2nd generation H1 blocker |
|
|
Term
|
Definition
| 3rd generation H1 blocker |
|
|
Term
|
Definition
| 3rd generation H1 blocker |
|
|
Term
|
Definition
3rd generation H1 blocker
longest t1/2 |
|
|
Term
|
Definition
| 3rd generation H1 blocker |
|
|
Term
|
Definition
H2 blocker
first available, interacted w/ CYP enzymes and made action of other drugs unpredictable |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
