Term
| what is the function of COX? LOX? |
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Definition
COX converts arachidonic acid to prostaglandins, prostacyclins and thromboxanes
LOX converts arachidonic acid to leukotrienes |
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Term
|
Definition
GI tract damage
bleeding
DECREASED renal perfusion |
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Term
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Definition
Aspirin
irreversible inhibitor of COX
good in low doses
SEs - aspirin asthma, rye syndrome, NSAID SEs |
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Term
| acetyc acid/phenylacetic acid |
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Definition
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Term
|
Definition
NSAID
favored by orthopedics |
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Term
|
Definition
NSAID
very potent
i.v. administered, used in anesthesia |
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Term
|
Definition
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Term
|
Definition
COX II inhibitor
only one still on the market |
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Term
| why were most "-coxibs" removed from the market |
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Definition
| they caused cardiovascular thrombotic events, MI, and stroke |
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Term
| Acetaminophen/Paracetamol; what causes toxicity? |
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Definition
antipyretic and mild analgesic
NOT an anti-inflammatory - no peripheral COX inhibition
-GSH deficiency prevents conversion of toxic metabolite to nontoxic -> liver necrosis |
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Term
|
Definition
used for acetaminophen overdose to ensure enough GSH in liver
*must give with alpha-1 agonist to combat vasodilation |
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Term
|
Definition
same mode of action as acetaminophen
antipyretic, STRONG analgesic, NO anti-inflammatory effect
Relaxes smooth muscle - spasmolytic effect, good for kidney and gallbladder stones
-if given in i.v. bolus can cause serious drop in BP |
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Term
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Definition
NSAID
LOX inhibitor
indicated for asthma
only one in USA |
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Term
|
Definition
| Leukotrine receptor antagonist (LT-RA) |
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Term
|
Definition
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Term
| what cleaves arachidonic acid from cell membrane? |
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Definition
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