Term
| main Cl channel inhibitor? exciter? |
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Definition
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Term
| GABA-a receptor agonists? antagonists |
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Definition
GABA
Benzodiazepines
Barbiturates
Propofol
Alcohol
Endozepines
Antagonist - Carbolines |
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Term
| Benzodiazepines; action? clinical effects? |
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Definition
-GABA-a receptor agonist, alpha-subunit ligand
-sedative, hypnotic
-amnestic
-muscle tone decrease
-anti-epileptic/seizure
*NO analgesia |
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Term
|
Definition
TOMB
Triazolam, Oxazepam, Midazolam, Brotizolam |
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Term
|
Definition
LETAL
Lorazepam, Estazolam, Temazepam, Alprazolam, Loprazolam |
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Term
|
Definition
| Diazepam, FLurazepam, Clotiazepam, Nitrazepam, Flunitrazepam |
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Term
|
Definition
Phase I (hepatic oxidation)
except: Temazepam, Oxazepam, Lorazepam |
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Term
| Non-benzodiazepine hypnotics and their duration |
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Definition
Zaleplon - ultra-short acting
Zolpidem - short acting
Zopiclone (lunesta) - longer acting |
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Term
| BDZ antagonist? use? common side effect? |
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Definition
Flumazenil
used for BDZ overdose
Can induce seizures and panic attacks, especially if patient is BDZ dependent |
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Term
| Barbiturates; action? clinical effects?ex's? |
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Definition
GABA-a agonist, beta-subunit ligand; Work without GABA
Effects - Sedative-hypnotic and Anti-epileptic
*NO analgesia
Thiopental, phenobarbitol |
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Term
|
Definition
barbiturate like
i.v. sedative, hypnotic (induces anesthesia)
short duration of action |
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Term
|
Definition
"vigorous GABA transaminase inhibitor"
anti-epileptic
inhibits GABA transaminase - increases GABA |
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Term
|
Definition
anti-epileptic
GABA-reuptake inhibitor - increases GABA |
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Term
|
Definition
GABA-B agonist (presynaptic)
reduces NT release
reduce muscle tone in people w/ spacticity |
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Term
|
Definition
used for chronic pain (marketed as antiseizure)
Acts on alpha-2 delta subunit of Ca-channel
recudes Ca and therefore NT release |
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Term
|
Definition
used for chronic pain
acts on Alpha-2 delta subunit of Ca-channel
Reduces Ca and therefore NT release |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
Long acting BDZ
Rohypnol (date rape drug) |
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Term
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Definition
| ultra-short acting non-BDZ hypnotic |
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Term
|
Definition
| short acting non-BDZ hypnotic |
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Term
|
Definition
Lunesta
longer acting non-BDZ hypnotic |
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Term
|
Definition
BDZ antagonist, used for BDZ overdose
Can induce seizures and panic attacks, especially in pt's dependent on BDZ
does not work for non-BDZ hypnotics |
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Term
|
Definition
Barbiturate
Sedative-hypnotic (anesthesia)
can cause release of Histamine -> pseudoalergic reaction |
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Term
|
Definition
Barbiturate
anti-epileptic |
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