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FIU - Ca channels
Ca channels
13
Pharmacology
Graduate
12/11/2011

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Cards

Term
Lente or L-type; describe, use, blockers
Definition
slow channels
for supraventricular arrhythmias
Verapamil, diltiazem, nifedipine
Term
Transient or T-type; describe, use, blockers
Definition
fast channels (only open briefly)
anti-seizure meds
ethosuximide, methsuximide, zonisamide, valproylamide, phenytoin
Term
NPQR or N-type
Definition
Decrease NT release
for chronic pain
Gabapentin and pregabalin
Term
verapamil; type? action? use? SEs?
Definition

non-selective (cardiac vs. vascular) L-type CaCB

decreases HR and O2 Uses - supraventricular arrhythmia SEs - constipation, edema, increased digoxin levels

Term
Nifedipine; type? action? T1/2?
Definition

vascular L-type CaCB

lower blood pressure

arteriole vasodilator - decreases afterload

3-4hr, halflife

Term
Diltiazem; type? action? use?
Definition
L-type CaCB
Decreases HR and 02 demand
Use - coronary artery vasospasm
Term
Ethosuximide; type? use?
Definition
T-type CaCB
Use - absanes petite mal seizures
Term
methsuximide
Definition
T-type CaCB
use - absence (petit mal) seizures
Term
zonisamide
Definition
T-type CaCB
Mixed mode of action (MOA) drug
Term
Valproylamides
Definition

T-type CaCB

anti-seizure

Mixed mode of action (MOA) drug

Term
phenytoin
Definition

T-type CaCB (NaCB and CaCB)

anti-seizure med

CYP 3A4 inducer

SEs - gum hyperplasia, Hirsuitism, folate deficiency, megaloblastic anemia, rash, peripheral neuropathy

Term
pregabalin and gabapentin
Definition
N-type/NPQR
reduce NT release
use - chronic pain
Term
Dantrolene
Definition
Ryanodine Receptor blocker
inhibits release of intracellular Ca from skeletal muscle sarcoplasmic reticulum
use- malignant hyperthermia
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