Term
# First stage of wound healing
# time course
# predominant cell type
# goal |
|
Definition
# inflammation
# Days 1-10
# PMNs and Macs
# Epithelialization |
|
|
Term
# Second stage of wound healing
# time course
# predominant cell type
# goal |
|
Definition
# proliferation
# 5 days-3 weeks
# fibroblasts
# neovascularization, collagen production, granulation |
|
|
Term
# Third stage of wound healing
# time course
# predominant cell type
# goal |
|
Definition
# Remodeling
# 3 wks to 1 yr
# fibroblasts and lymphocytes
# type III collagen replaces type I |
|
|
Term
| Amount of wound healing that happens during epithelialization stage |
|
Definition
|
|
Term
| Amount of regeneration in peripheral nerves/day |
|
Definition
|
|
Term
| Order of cells to arrive at wound site |
|
Definition
1. platelets
2. PMNs
3. Macrophages
4. Fibroblasts
5. Lymphocytes |
|
|
Term
| Most import cell for wound healing and reason |
|
Definition
| Macrophages release growth factors and cytokines and probably clearing debris with phagocytosis |
|
|
Term
| Prominent cell type by day |
|
Definition
0-2: OMNs
3-5: Macs
>5: fibroblasts |
|
|
Term
| Contents and purpose of platelet alpha granules |
|
Definition
# PF4- aggregation
# betathrombomodulin- binds thrombin
# PDGF: chemoattractant |
|
|
Term
| Contents of dense granules |
|
Definition
Adenosine
Serotonin
Calcium |
|
|
Term
| Factors that promote platelet aggregation |
|
Definition
|
|
Term
| Other factors released from plts not in granules |
|
Definition
# Platelet activating factor
# TGF-alpha
# Beta lysin- antimicrobial
# PGE2- vasodilator
# PGI2- vasodilator
# PGF2- vasoconstriction |
|
|
Term
| Most important factor for healing by secondary intention (open wounds) |
|
Definition
|
|
Term
| Most important factor for healing by primary intention (closed wounds) |
|
Definition
|
|
Term
| Strength layer of the bowel |
|
Definition
|
|
Term
| Limiting factor dictating tensile strength |
|
Definition
| Deposition and cross-linking of collagen |
|
|
Term
| Most common type of collagen |
|
Definition
|
|
Term
| Important places Type I collagen is found |
|
Definition
|
|
Term
| Primary cartilage in HEALED wound |
|
Definition
|
|
Term
| Primary cartilage in healing wound |
|
Definition
|
|
Term
| Important places where type II collagen is found |
|
Definition
|
|
Term
| Important places type III collagen is found |
|
Definition
|
|
Term
| Important places type IV collagen is found |
|
Definition
|
|
Term
| Important places type V collagen is found |
|
Definition
|
|
Term
| Factors necessary for hydroxylation of proline and subsequent cross-linking of Pro residues |
|
Definition
Alpha-ketogluterate
Iron
Vit C
O2 |
|
|
Term
| Frequency of Pro in collagen |
|
Definition
|
|
Term
| Maximum tensile strength achieved in wound healing |
|
Definition
| 80% of pre-wound strength |
|
|
Term
| Strength of wound at 6 weeks |
|
Definition
| 80% of final strength; 60 % of pre-wound strength |
|
|
Term
| Strength of wound at 8 weeks |
|
Definition
| Maximal tensial strength- 80% pre-wound strength |
|
|
Term
| Counteracts the effects of steroids on wound healing |
|
Definition
|
|
Term
| Defect in osteogenesis imperfecta that effects wound healing |
|
Definition
|
|
Term
| Defect in Marfan's syndrome that affects wound healing |
|
Definition
|
|
Term
| Defect in Ehlers-Danlos syndrome that effects wound healing |
|
Definition
|
|
Term
| Defect in epidermolysis bullosa that effects wound healing AND TX |
|
Definition
| Excessive fibroblasts; Tx is phenytoin |
|
|
Term
| Cause of and treatment for leg ulcers |
|
Definition
| 90% are due to venous insufficiency. Tx is Unna boot and elastic wrap/ elevation |
|
|
Term
| Method of inheritance of keloids |
|
Definition
|
|
Term
| Difference b/w keloids and hypertrophic scars |
|
Definition
| In keloids, collagen gois behoid original scar whereas in hypertrophic scar, it stays within the confines of the original scar |
|
|
