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First Aid Step 3 Infectious Disease 11
Antimicrobial Selection
38
Medical
Professional
12/27/2013

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Term
What are examples of First-generation penicillins?
Definition
Penicillin G
Penicillin V
Term
What organisms are appropriate for First-generation penicillins?
Definition
Treponema pallidum
Enterococcus
Streptococci
Pen sensitive Staphylococci
Term
What are examples of Second-generation (Beta-lactamase-resistant penicillins)
Definition
Dicloxacillin
Methicillin
Nafcillin
Oxacillin
Term
What organisms are appropriate for Second-generation penicillins?
Definition
Methicillin-sensitive staphylococci
But, they do cover streptococci as well.
Term
What are examples of Third-generation or aminopenicillins?
Definition
Amoxicillin
Augmentin
Ampicillin
Ampicillin/Sublactam
Term
What organisms do third generation penicillins cover?
Definition
Treponema pallidum
Enterococcus
Streptococci
Term
What are fourth generation (extended) penicillins?
Definition
Piperacillin/tazobactam, ticarcillin/clavulanic acid
Term
What organisms do fourth generation penicillins treat?
Definition
aminopenicillins/Beta lactamase inhibitor coverage in addition to resistant G- organism and Pseudomonas
Term
What are first generation cephalosporins?
Definition
Cefaxolin
Cephalexin
Term
What organisms do first generation cephalosporins treat?
Definition
staphylococci, streptococci, proteus, E. coli and Klebsiella
Term
What are second generation cephalosporins?
Definition
Cefaclor
Cefuroxime
Term
What organism do second generation cephalosporins treat?
Definition
H. influenza, Enterobacteriaceae, Neisseria, Staphylococci, streptococci, proteus, e. coli, and Klebsiella
Term
What are Cephamycins?
Definition
Cefotetan
Cefoxitin
Term
What organisms do cephamycins treat?
Definition
2nd generation coverage and G-/+ anaerobes
Term
What are third generation cephalosporins?
Definition
Cefotaxime
Ceftazidime
Ceftriaxone
Term
What organisms do third generation cephalosporins treat?
Definition
Most gram - aerobes
Ceftriaxone adds streptococcal coverage
Ceftazidime adds pseudomonas coverage
Term
What are fourth generation cephalosporins?
Definition
Cefepime
Term
What organisms are treated with fourth generation cephalosporins?
Definition
Gram- aerobes, streptococci, and pseudomonas
Term
What are second generation quinolones?
Definition
Ciprofloxacin
Term
What organisms are treated with second generation quinolones?
Definition
G- aerobes, and atypicals such as legionella, mycoplasma and chlamydia. Best pseudomonas coverage of all quinolones.
Term
What are third generation quinolones?
Definition
Levofloxacin
Term
What organisms are treated with third generation quinolones?
Definition
G- aerobes, streptococci, and atypicals like legionella, mycoplasma, and chlamydia.
Term
What are fourth generation quinolones?
Definition
Gatifloxacin
Moxifloxacin
Term
What organisms do fourth generation quinolones treat?
Definition
G+, some anaerobes, weak G- coverage and atypicals like legionella, mycoplasma and chlamydia.
Term
What are the carbapenems?
Definition
Ertapenem
Imipenem
Meropenem
Term
What organisms do carbapenems treat?
Definition
G+ (except staph and enterococcus)
G- including pseudomonas and anaerobes
Ertapenem has no pseudomonas coverage
Term
What are the macrolides?
Definition
Azithromycin
Erythromycin
Clarithromycin
Term
What organisms do macrolides treat?
Definition
G+ organisms and atypicals
Term
What are aminoglycosides?
Definition
Gentamycin
Tobramycin
Term
What organisms do aminoglycosides treat?
Definition
G- aerobes
Term
What does Aztreonam treat?
Definition
G- aerobes including pseudomonas
Term
What does clindamycin treat
Definition
G+ anaerobes
Term
What does Dalfopristin/quinupristin treat
Definition
MRSA and VRE
Term
What does Linezolid treat?
Definition
MRSA and VRE
Term
What does Metronidazole treat?
Definition
Anaerobes (C.Diff)
Term
What does TMP-SMX treat?
Definition
G-, G+, and PCP
Term
What does vancomycin treat?
Definition
MRSA and C. diff
Term
What are tetracyclines?
Definition
Doxycycline
Minocycline
Tigecycline
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