Term
| SLE is a _ multisystem disease |
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Definition
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Term
| lupus erthmeateux means it occurs where? |
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Definition
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Term
| SLE is autoantibody production to what? |
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Definition
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Term
| how mnay criteria are needed for diagnosis of SLE? |
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Definition
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Term
| how many cases per 100,000 ppl |
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Definition
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Term
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Definition
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Term
| between what ages is it diagnosed |
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Definition
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Term
| the etiology of SLE is still |
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Definition
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Term
| how mnay susceptibility genes are required for expression of lupus |
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Definition
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Term
| 1st degreee relatives of SLE person is _ times likely to get SLE |
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Definition
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Term
| triggering env factors (3) |
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Definition
| sunlight, hydazine, aromatic amines |
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Term
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Definition
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Term
what sex hormone inhibits expression?
which enhances? |
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Definition
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Term
SLE has production of abnormal amount of what?
this leads to increase? |
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Definition
autoantibodies
immune complexes |
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Term
| excess autoantibodies comes from hyperactive? |
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Definition
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Term
| t cells switch types from what to what? |
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Definition
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Term
| antibodies to what kind of DNA is in 80% of SLE |
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Definition
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Term
| what 4 RNA associated antigens are in SLE |
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Definition
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Term
| antibodies to what make up the lupus anticoagulant |
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Definition
| phospholipid part of prothrombin activator |
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Term
| what make up the antiphospholipid antibodies |
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Definition
| lupud anticoag and anticardiolipin |
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Term
| what 4 types fo antiboides are present many years before SLE diagnosis |
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Definition
| Antinuclear, Anti-Ro, Anti-La, antiphospholipids |
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Term
| what 2 types of antibodies are only months before diagnosis |
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Definition
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Term
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Definition
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Term
| what body system is invovled usually |
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Definition
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Term
| what joints may be affected? |
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Definition
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Term
| butterfly rash is in _% of patients |
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Definition
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Term
| discoid lupus is in _% of patients |
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Definition
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Term
| a common cutaneous manifestation besides butterfly rash it |
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Definition
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Term
| what is a common pulmonary infection with lupus |
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Definition
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Term
| cardiac manisfestation usually present as |
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Definition
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Term
| what cardiac problem is seen more as life expectancy increases |
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Definition
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Term
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Definition
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Term
| what hematologic problems= occurs in disease exacerbation |
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Definition
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Term
| what is a commen hematoglic problem |
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Definition
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Term
| lupus nephritis is associated with increased risk of |
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Definition
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Term
| what stage of lupus nephritis has sceloritc lesions >50% |
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Definition
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Term
what diagnostic test is for SLE?
if it presents with _ its positive for SLE? |
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Definition
ANA
peripheral pattiern (rim) |
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Term
| For SLE diagnosis the antigen for peripheral is |
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Definition
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Term
| For SLE diagnosis the antigen for speckled |
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Definition
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Term
| For SLE drug induced diagnosis the antigen for homomgenous |
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Definition
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Term
| what are the 3 main causes of death |
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Definition
| complications of treatment, CAD, infection |
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Term
| manisfestations that can be handled with antimalarials are |
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Definition
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Term
| what type and when do you use steroid therapy |
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Definition
pulse
remission if have life threatening disease |
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Term
| drugs indicated fro inducing SLE (4) |
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Definition
chlorpromazine
minocycline
methyldopa
quinidine |
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Term
| what is gold standard treatment for lupus nephritis and severe lupus |
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Definition
| cyclophosamide + methyl prednisolone |
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Term
| what is the active metabolite of azothioprine |
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Definition
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Term
| MOA of azothioprine involves what 2 paths |
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Definition
block purine synth
T cell apoptosis |
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