Term
| osteoporosis is characterized by what 2 things |
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Definition
low bone density
deteriation of bone tissue |
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Term
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Definition
| precursor conditon with low bone densisty |
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Term
| osteoporis bone fractures are more common in what gender |
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Definition
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Term
| bone mineral density is expressed as a |
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Definition
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Term
| T score shows the BMD as a _ above or below the mean BMD fro normal person |
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Definition
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Term
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Definition
| Persons BMD-avg BMD/ SD of normal |
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Term
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Definition
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Term
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Definition
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Definition
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Term
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Definition
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Term
| are most OP cases diagnosed and treated? |
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Definition
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Term
| when adj by BMD, weight , etc- which 2 races have higher fragility fracture rate |
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Definition
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Term
| what type of fracture is more common among seniors? |
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Definition
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Term
| what type of fracture costs the most |
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Definition
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Term
| _ % of ppl with hip fracture die within 1 year |
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Definition
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Term
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Definition
| age related, postmenopasual, secondary |
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Term
post menopausal OP is caused by loss of ?
affects primarily what bones |
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Definition
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Term
| age related OP caused by rate of bone _ exceding rate of _ |
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Definition
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Term
| postmenopasusal OP lose _% of density within 5-10 yrs |
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Definition
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Term
estrogen loss induces release of _ from osteoblasts and monocytes?
this causes increase in
_, decrease in _ |
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Definition
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Term
| estrogen loss end result is activation of |
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Definition
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Term
| the more bone remodeling sites- the deeper _ |
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Definition
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Term
| when does bone mineral density peak? |
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Definition
| btwn 2nd and 4th decade of life |
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Term
| women have less bone mass at maturity- so- |
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Definition
| need less lost to reach OP |
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Term
| after age _ resoprtion exceeds formation |
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Definition
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Term
age related bone los results from:
decrease _ function
decreased _ intake
reduced synth of _
decreased |
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Definition
osteoblast
Ca and Vit D
sex hormones
mechanical stress |
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Term
| what drugs can cause OP-4 |
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Definition
glucoceteroids
heparine
thyroid
anticonvulsants |
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Term
| diseases that can cause OP 4 |
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Definition
| hyperparathyroid, hypo/hyperthyroid, type 1 diabetes |
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Term
| modifiable risk factors- 5 |
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Definition
BMD- diet exercise
smoking
alcohol
low estrogen
minimal sun |
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Term
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Definition
| exagerated curve of thoracic spine-roundback |
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Term
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Definition
| curve of lumbar spine- swayback |
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Term
multiple fractures lead to
- |
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Definition
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Term
| what is the most common fracture overall? which is the worst? |
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Definition
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Term
_% of hip fracture pateints are unable to walk after
_% will need nursing home |
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Definition
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Term
| what contains 99% of total calcium in body |
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Definition
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Term
| what increases calcium excretion |
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Definition
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Term
calcium intake for regular
for OP |
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Definition
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Term
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Definition
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Term
| what are the 2 methods of calcium uptake |
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Definition
active trnasport by Vit D
facilitated diffusion |
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Term
| how much Ca is excreted each day? |
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Definition
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Term
| reabsoprtion of Ca is regulated by |
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Definition
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Term
what is bone remodeling
is there more osteoblast or clast activity in it? |
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Definition
process of breakdown and renewal;
osteoblast |
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Term
| which type of bone has more remodleing? |
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Definition
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Term
| multinuclear osteoclasts are activated by |
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Definition
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Term
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Definition
| projections that attach to bone |
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Term
| what 2 things does osteoclasts secrete to dissolve bone matrix |
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Definition
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Term
| resorption phase is complete when _ replace the resorbed bone |
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Definition
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Term
| osteoblasts secrete _ which is a deocy for |
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Definition
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Term
D2 or D3
ergocalciferol
cholecalciferol |
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Definition
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Term
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Definition
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Term
| just D3 can be obtained from? |
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Definition
| production from UV B light action of 7-dehydrocholest |
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Definition
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Term
25hydroxyvitamin D converted to dihydroxyvit D by -?
what is the other name for this vit D metab? |
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Definition
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Term
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Definition
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Term
| calcitrol is stimulated by 2 things |
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Definition
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Term
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Definition
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Term
| PTH enhance Ca reabsorption where |
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Definition
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Term
| PTH enhances production of |
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Definition
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Term
| bad side affect of PTH is it also increases - |
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Definition
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