Term
| new risk factors for gout- 4 |
|
Definition
kidney impairment
insulin resisitance
purine rich diet
osteoarthritis |
|
|
Term
| what causes rapid changes in uric acid level |
|
Definition
chemo
diuretic
start stop allopurinol |
|
|
Term
| what are common triggers for attack |
|
Definition
IV contrast
acidosis
low body temp |
|
|
Term
| for an attack do you apply topical cold or hot |
|
Definition
|
|
Term
| what is weight reduction good for |
|
Definition
|
|
Term
| diet changes- eat less of |
|
Definition
|
|
Term
1st line for attack
what dose |
|
Definition
|
|
Term
| when do you take celecoxib |
|
Definition
|
|
Term
| what is 2nd line agent in attacks |
|
Definition
|
|
Term
| need to give colchicine in < _ hrs after attack |
|
Definition
|
|
Term
|
Definition
2 tabs at onset, 1 tab 1 hr later
12 hrs later- .6 mg |
|
|
Term
| what is most common adverse effect of colchicine |
|
Definition
|
|
Term
| when will you see reolution of attack with colchine |
|
Definition
|
|
Term
| do not give cochicine to ppl on _ inhibitor or _ inhibitor |
|
Definition
|
|
Term
| what is used as absolute last line therapy fro attack |
|
Definition
|
|
Term
| what 3 things would signal monotherapy |
|
Definition
mild-mod
1 large joint
few small joints |
|
|
Term
| what 2 factors signal combo therapy |
|
Definition
|
|
Term
consider prophylaxis if:
_ is assoc. with an attack
if serum uric acid > _
24 hr excretion is > |
|
Definition
|
|
Term
consider prophalxis if:
_ is present
_ gout attack/year
_ dysfunction |
|
Definition
|
|
Term
with prophylaxis goal is:
lower serum uric acid to < _ |
|
Definition
|
|
Term
| 1st line anti-inflamm prophylaxis in all patients (2 options) |
|
Definition
|
|
Term
| what needs to be known before pick 2nd line prophylaxis (2 things) |
|
Definition
over producer, under excretion
renal function |
|
|
Term
|
Definition
probenecid
sulfinpyrazone
losartan
fenofibrate |
|
|
Term
| prophylaxis colchicine dose |
|
Definition
|
|
Term
| colchicine prophylaxis contraindicated if Cr Cl< |
|
Definition
|
|
Term
| NSAID is high/low in prophylaxis |
|
Definition
|
|
Term
| caution NSAID use in prophylaxis if (2 things) |
|
Definition
bad renal function
GI probs |
|
|
Term
| duration of anti-inflamm meds for prophylaxis |
|
Definition
|
|
Term
avoid uricosurics if:
_ type of gout attack
CrCl<
history of _ |
|
Definition
|
|
Term
don't use uricosurics if:
active _
using this class of meds- |
|
Definition
|
|
Term
| what med class do you push fluids on |
|
Definition
|
|
Term
uricosurics0
at baseline need to get- |
|
Definition
|
|
Term
uricosuric
monitor (3 things |
|
Definition
|
|
Term
| what is the drug class of choice for overproducers |
|
Definition
| xanthine oxidase inhibitors |
|
|
Term
| xanthine oxidase inhibitors interact with what other drugs (4) |
|
Definition
azathiopurine
mercaptopurine
theophylline
didanosine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| allopurinol or febuxostat as evidence of prevention |
|
Definition
|
|
Term
| allopurinol or febuxostat cheaper |
|
Definition
|
|
Term
| what is a last line med for prevention |
|
Definition
|
|
Term
use pegloticase with:
_ type of gout
cant take _ option |
|
Definition
|
|
Term
|
Definition
|
|
Term
| pegloticase black box warning of |
|
Definition
|
|
Term
| warning of _ with pegloticase |
|
Definition
|
|
Term
| what meds must be discontinued when start pegloticase |
|
Definition
|
|
Term
| what is the recombiannt urate-oxidase enzyme med |
|
Definition
|
|
Term
| what is the indication to sue rasburicase |
|
Definition
|
|
Term
| blackbox warning for rasburicase (3) |
|
Definition
anaphylaxis
hemolysis
methemoglobinemia |
|
|
