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Final
Final exam
50
Physiology
Undergraduate 3
12/06/2009

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Term
homeostasis
Definition
maintaining a constant internal environment
Term
Motor proteins that travel along microtubule tracts
Definition
Dyenin and Kynesin
Term
Transcription
Definition
Making RNA from DNA through a process of creating an equivalent RNA copy of a sequence of DNA
Term
Constituents of phosphatidylcholine
Definition
glycerol, phosphate, choline, and 2 fatty acid chains
Term
surfactants
Definition
reduces the surface tension of a liquid
Term
How are proteins anchored in the membrane?
Definition
Peripheral, integral/transmembrane proteins. Glycolipids. Myristyl, farnesyl, and GPI anchors.
Term
Post-translational modification of proteins
Definition
acetylation, methylation, hydroxylation, y- carboxylation, glycosylation, myristylation/plamitylation, and phosphorylation
Term
Post-translational modification of histones
Definition
acetylation, methylation, phosphorylation, and ubiquitinylation. NOT FARNESYLATION.
Term
What increases diffusive flux?
Definition
concentration
Term
What is the Stokes-Einstein equation?
Definition
D= (kT)/(6(pi)(eta)a)
Term
What is the equation for electrochemical potential?
Definition
(mu)=(mu)0+RTlnC+z(faraday)(psi)
Term
What can increase primary active transport?
Definition
The number of transport proteins.
Term
Where does passive permeability derive its energy from?
Definition
The electrochemical gradient.
Term
What is the equation for the reflection coefficient?
Definition
(pi)observed=RT(cap.sigma)(sigma)C(phi)
Term
What is the equation for microporous permeability?
Definition
p= (n(pi)a^2D)/(delta)
Term
What is the equation for biological permeability?
Definition
p=(KD)/(delta)
D-D of a lipid
Term
What is the equation for hydraulic permeability?
Definition
Lp=(n(pi)a^4)/(8(eta)(delta))
Term
Red blood cells are placed into solution A. You then take out the RBC and look at them under a microscope, the cells look like spiky balls. What type of solution is it?
Definition
hypERtonic
Term
ADP1,3 diphosphate --> ATP+Pi. What is this?
Definition
Substrate level phosphorylation
Term
The Electron Transport Chain
Definition
Links chemical energy to H+ pumping from the inner mitochondrial matrix to the membrane.
NADH feeds into the beginning of the ETC—3 complexes pump H+.
FADH2 feeds into the ETC after complex I only II complexes pump H+.
The final electron acceptor is oxygen; without it, the whole ETC backs up.
Term
With the complete oxidation of one mole of pyruvate, what is produced?
Definition
4 NADH,
1 FADH2,
1 GTP,
3 CO2
Term
What are the three ketone bodies?
Definition
Acetone, acetoacetic acid, and beta hydroxyk buteric acid.
Term
Given an Action Potential Graph, be able to determine where the Na activation gates are open and where that NA inactivation gates are closed.
Definition
Term
Myelination increases conduction velocity. What does it do to the transmembrane potential?
Definition
Increases resistance across membrane and decreases capacitance
Term
What is the end plate potential?
Definition
The binding of ACH reasulting in the graded depolarization of the muscle cell.
Term
Define chord conductance
Definition
g=(Em-Ei)/I
Em=(ENa)(gNa/(gNa+gK+gCl))+(EK)(gK/(gNa+gK+gCl))+(ECl)(gCl/(gNa+gK+gCl))
Term
What is resting membrane potential mainly determined by?
Definition
It is a conductance-weighted average of the equilibrium potentials for the ions that possess conductance across the membrane.
Term
Calculate the maximum power of a muscle given area and velocity, and compare the ratio of the two (Pa to Pb=).
Definition
Term
Why is a fast twitch muscle fast?
Definition
Myosin exists in multiple isoforms that can be distinguished by myosin staining. Slow-twitch muscles have myosin I and fast-twitch muscles have isoforms of myosin II. They differ in their turnover number; faster cross-bridge cycling causes faster shortening.
Term
Why does muscle force persist after Ca transient?
Definition
elastic elements
Term
What happens to the H zone, I band, A band, etc, for concentric muscle contractions.
Definition
H-zone: Where thin filaments do not overlap thick filaments (clearer area in the middle of thick filaments).
I-band: Thin filaments do not overlap thick.
A band: Length of thick filament.
Z-line: Thin filaments of opposite sides attach.
M-line: Keeps thick filaments centered.
Term
Why does lactic acid increase during anaerobic threshold?
Definition
One, because the rest period between the contractions is shorter. Two, because the fast glycolytic fibers are increasinglyrecruited over the oxidative fibers, which causes a release of more lactic acid. Three, the sympathetic nervous system increases the rate of glycolysis, increasing the supply of pyruvate and, by mass action, lactate.
Term
Do alpha and beta adrenergic receptors cause relaxation or contraction?
Definition
alpha contraction, beta relaxation
Term
What activates Gs?
Definition
Dopamine, Norepinephrine, and Epinephrine.
Term
What are epinephrine, norepinephrine, and dopamine synthesized from?
Definition
Tyrosine.
Term
Cuneatus receptors are through what nerve?
Definition
Vagus (CN X)
Term
What is the difference between CSF (cerebrospinal fluid) and ECF (extracellular fluid)?
Definition
CSF lacks the high protein level of the plasma, so its osmolarity is balanced by the increased concentrations of Na+ and Cl-.
Term
What does the withdrawal reflex activate (extensor/reflexor, contralateral/isolateral)?
Definition
contralateral-extensor, isolateral-reflexor.
Term
Where is the primary motor cortex located?
Definition
anterior of the central sulcus
Term
How do you increase skeletal muscle force?
Definition
recruit more fibers
increase the frequency of stimulation
vary the length
Term
What nerve are pungent odors carried over?
Definition
Trigeminal nerve (CN V)
Term
Where does the Organ of Corti Afferents originate?
Definition
Cochlea.
Term
What is the blind spot caused by?
Definition
Optic nerve.
Term
When a light is shined on a rod cell, what happens to gGMP, gNa, and glutamate?
Definition
1. Transducin is activated.
2. Activation of cGMP phosphodiesterase.
3. Decrease in [cGMP].
4. Reduces gNa and glutamate.
5. Hyperpolarizes the cell.
Term
Where do the parasympathetic nerves originate?
Definition
cranial and sacral
Term
What does not use ACH as a neurotransmitter?
Definition
Post-ganglionic sympathetic.
Term
Why is swallowing programmed?
Definition
Because the timing must be perfect between the covering of the trachea (to avoid food in the lungs= pneumonia and death), and choking on big particles of material (avoided by the mechanoreceptors on the pharynx= gag reflex).
Term
How does the small intestine churn chyme?
Definition
Segmentation.
Term
What part of the brain inhibits food uptake?
Definition
Ventromedial hypothalamus.
Term
What activated pancreatic secretion?
Definition
CCK
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