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final
acne, clinical trials, ext
80
Pharmacology
Undergraduate 1
12/05/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Pharmacokinetics
Definition
The effects of the body on drugs
Term
Definiton of Pharmacology
Definition
The body of knowledge concerned with the action of chemicals on biological systems
Term
Pharmacodynamics
Definition
The actions of the drugs on the body
Term
Absorbtion and the factors
Definition

Process where drug enters the blood stream

1. route

2.food or alcohol

3. chemical properties

4. Types of liquid used to take meds

5. acidity of stomach

Term
Clinical Trials Phase 1
Definition
Careful of evaluation of doseage in humans to see if it is safe, small # of human volunteers
Term
Clinical Trials Phase 2.
Definition
Moderate # of human volunteers if agent has desired affect and works the way it is designed to work.
Term
Clinical Trials Phase 3
Definition
Explore of benifical actions, large # of human volunteers
Term
Clinical Trials Phase 4
Definition
Drug is approved and side effects are reported.
Term
Drug Safty Grade A
Definition
Fail to deminstrate the risk of fetus "Safe" in 1st trimester, fetal harm is remote
Term
Drug Safty grade B
Definition
Fail to deminstrate fetal risk but no control studies in pregnant women
Term
Drug Safty Grade C
Definition
Most Drugs, Studies of animals have adverse affect and kill the getus of embreos. Not studies in humans.  Studies not aviable.
Term
Drug Saftey Grade D
Definition

Positive evidence in human fetal risk only use in life threatening cases in which mother needs to stay alive.  Damage is done to the fetus. 

Ex: Blood pressure drugs

Term
Drug Safety Grade X
Definition
DON'T USE THEM, RISH OUT WAYS ANY AFFECTS
Term
Biovailability
Definition

Administered vs. absorbed

IV only 100% biovailability

the abount absorbed into the systemic circulaiton divided by the amount of drug administered

Term
Drug of choice for Enterobacter
Definition
Carbapenem
Term
Drug of choice for strep throat
Definition
Penicillin/Amoxycillin
Term
Drug of choice for dental infections
Definition
Clindamycin
Term
Drug of Choice for vaginal caninosis
Definition
Fluconazole
Term
Vancomycin
Definition

Bacterialsytial

Used in gram + only

Used for serious infections by drug resistant gram +

Side effects: irretation in veins, FEVER, kindneys to shut down.

Term
Methods of Contraceptions
Definition

1. absitinence

2.Condom

3. Animal membrane condom

4. sponges

5. timing

6. Rhythm

7. Diaphragm

8. Elephant or crocodile dung

9. Hormonal Contraceptions

Term
Absolute containdications to contraceptive
Definition

Do not use if they have these

1. have clot

2. strole

3. heart attack

4. estrogen dependent cancer/ breast cancer

5. smoker

6. over the age of 35

7. pregnant

Term
Relative Contraindications to contraceptive
Definition

Take precaution

1. migraines that are worsened by menstrual periods

2. Hypertension/high blood pressire

3. high sugar/diabetes mellitus

4.thyroid

5. sickle cell

6. nausa

7. headache

8.Irregular bleeding

9. bladder retention

10. weight gain

11. morea acne

12. mood swings

Term
Which drug is more effective for COPD vs asthma
Definition
Tiotropium(Spiriva)/Anticholinegics
Term
Warnings of medications
Definition
Black box warnings
Term
Asthma
Definition

Chronic lung diease, air flow ubstruction and broncospasim.

-inflammation and mucus

Term
Asthma Attack
Definition
Acute exacerbation of astham resulting in difficulty breathing, chest tightness, SOB, cough
Term
Status Asthmalicus
Definition
A severe asthma attack that does not respond to usual treatment modalities, silence of chest
Term
How to diagnose Asthma
Definition

Pulmonary Function Test

FEVI

Peak Flow Meter

Term
What is used to monitor asthma treatment
Definition

Short acting used to monitor asthma

ex: adrenoceptor agonist, subanex

Term
Asprin
Definition

Inhibit the formation of postaglandins and thromboxane which are inflammatory medicators

- ASA

-NSAIDS

Term
Antidote to Tylenol
Definition
Acetylcucteine ( Mucomyst)
Term
Most effective to Gout
Definition
NSAID- especialy indomethacin ( Indocin)
Term
Live Vaccines
Definition

Attenuted Vaccines, does not give you the virus, causes immune responce

ex:Measles

Oral Polop

Term
Inactivated Vaccines
Definition

Killed by heat of chemical cources but still able to induce imminity

ex: tetanus, Rabies, Hapatitis A, 

Term
Vaccines and Egg allergies
Definition
Influenzia
Term
Hormones seceted from anterior pituratary gland
Definition

FLGPAT (Fran likes gardening potatos and trees)

1. Folllic stimulating hormone

2. Lutenizing Hormone

3. Growth Hormone

4. Prolactin

5. Adreniocordico Hormone

6. Thyroid Hormone

 

Term
Posterior Pituatary Gland Hormones
Definition

1. Ocytocin

2. Antiduretic Hormone

Term
Hypothyroidism Labs
Definition
How much is floating in the blood. TSH and T free
Term
Hypothyrodism treatment
Definition
Levothyrozine- synthetic  T4 (Synthroid)
Term
Side Effects to SSRI
Definition

1. Agotated

2. Anxiety

3. Sleeping disorters

4. Dry Mouth

5. Dizzyness

6. Lowers seizure threshold

Term
Side effets of anti-psychotic drugs
Definition

Parkinson like syndrome

Irreversible movements of lps and buccal cavity

confusion

Orthostatic Hypotension

Gynecomastia

Amenorrhea

Infertility

weight gain

hyperglucemia

Sedation

Visual changes

OD

Prolonged QT lntervals

Term
drugs used for smoking sesation
Definition

SNRI

Baproprion( wellbutrin, XL, SR)

Ziban

Term
Side Effects to Insulin
Definition

Hypoglycemia

Rash @ injection site

Weight gain

Term
Adverse effects to vaccines
Definition

Unspecifed rash

fever

injection site reaction

Term
Anadote of Comadin
Definition
Vitamin K
Term
Anadote for Heprin
Definition
Protamine Sulfate
Term
Drug Combinations
Definition

1. Sever infections

2. Polymicrobial- multiple infections

3.Brian- Meningitis

4. abdominal- intestinal

5. Prevent resistance

Term
Side effects to Corticosteriods
Definition

1. moon face

2. prevents growth

3. suppress immune system

4. CNS efects

5. Ulcers

6. Behavioral Changes

Term
Genarian
Definition
You are immune to smallpox
Term
MOA of acne medications
Definition
Comedolutic and anti-inflammatory and normalize folicular hyperproliferation and hyperkeratinization- preventing black and white heads from accoring and inflammaiton
Term
Overdose to naradic what drug you will use
Definition
Naloxone
Term
MOA for anti-diabetic drug Biguanides
Definition

Inhibit hepatic and renal glucogneogenesis

Stimulate gluces uptake

Glycolysis in perpheral tissues

Decreases intestinal glucose absorbtion

Increase insulin sensitivity

Term
MOA for anti-diabetic drugs Sulfonylareas
Definition
Stimulates pancreatic islet b-cell insulin release, if you do not produce beta cell production these meds will not work
Term
MOA for anti-dabetic drugs Meglitinides
Definition
Stimulates pancreatic islet b-cell insulin release
Term
MOA for anti-diabedic Drugs Thiazolidinediones IZD
Definition

Increase insulin sensitivity

increases storage of glucose as gylcogen in muscle and adipose tissue

Decrease gluconeogenesis

Term
MOA for anti-diabetic drugs Glucosidase Inhibitor
Definition
Prevents glucose from being absorbed
Term
Diatary Sublement Saw palmetto
Definition
BPH, enlarged prostate
Term
Diatery Suplement Coenzyme Q10
Definition
acne, reduced myalgia
Term
Diatery Suplement Red Yeast Rice
Definition
lowers cholesterol
Term
Diatery Suplement Fish Oil
Definition
Lowers triglycerides, anti inflammatory
Term
Diatery Suplement Glucosaminew
Definition
joints, rebuilds the bodies natural cartilage in joints
Term
Dietery suplement Melatonin
Definition
Sleep
Term
Dietary Suplemetn Garlic
Definition
Cardio, hypertension
Term
Dietary Suplement  Ginako Biloba
Definition
memory, depression, dementia, altitude sickness
Term
Dietary Suplement Cinnamon
Definition
Hypolipodemia
Term
Dietary Supplement Cranberry
Definition
UTI
Term
Dietary Supplement Black Cohosh
Definition
Hot flashes, vacomotor syymptoms and metapose
Term
Dietary Supplement Creatine
Definition
Builds up muscle mass
Term
Dietary Supplemetn DHEA
Definition
Addisons diease
Term
Dietary Supplement Flaxseed Oil
Definition
heart, athrocelorsis, constipation, BPH, my prevent cancer
Term
Dietary Supplement Peppermint
Definition
GI upset, calicy baby
Term
Dietary Supplement St Johns Wart
Definition
Depression, anxiety, ADHD
Term
Toxicology
Definition
The branch of pharmacology that encompasses the deleteriouse effects of chemicals on biological systems- what are the negative side effects based on the drugs given.
Term
Carbon Monoxide
Definition

Colorless, odorless gas that aggressively compets with oxygen for hemoglobin

-results in tissue hypoxia

-Signs and Symptoms:

1. Headache

2. Confusing

3. Tiredness

4. Comma

5. Hypoxia

 

 

Term
Heavy Metals
Definition

No useful purpose in body

damages hematopoietic tissues, liver and nervous system

-Acute-

1. Abdomenial Pain

2. SNS changes

3. High mortality rate

4. Encephalopathy- swelling of the brain

-Chronic-

1. PNS changes- periphialnorpathy (wrist drop)

2. Anorxia

3.tremors

4. GI-symptoms

5. in children causes mental retardation, growh retardation and developmental delay.

Term
Arsenic
Definition

-Acute-

1. sweet garlicky odor on the breath

2. vomiting

3. servier abdominal gain

4. Rice water stools.

-Chronic-

1. Skin chnges

2. hair loose

3. nausea

4. Aniema

 

Term

Management of the poisoned Patient

Vital Functions

Definition

ABCD

A= airway

b=breathing

c=circulation

d=detroxe

Term

Management of Poisoned Patient

Identify Poison

Definition

1. Blood work

2. Urine Test

3. Toxicology panel

4. Decontaminate the patient

5. skin wise, remove cloting and wash patient

6. Gastriclapoges

7. Bowl irrigation with ployethalinegical

8. Activated charcoal

Term

Management of the Poisoned Patient

Decontamination

Definition

Gastric Lavage

Activated Charcoal

Syrup of Ipecac

Whole Bowl Irrigationwith polyethylene glycol

Cathartics such as sorbitol to decrease absorption and hasten removal.

Term
MOA for Coumadin
Definition
acts on 2, 7, 9, 10
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