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| Negative Symptoms of Psychosis |
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Definition
Blunted affect
Emotional withdrawal
Poor rapport
Passivity
Social Withdrawal
Anhedonia
Attention impairment
Apatheticiculty in abstract thinki
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Criteria A: Two or more of the following symptoms
1.Delusions
2.Hallucinations
3.Disorganized Speech
4.Grossly disorganized or catatonic behaviors
5.Negative symptoms
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Term
| Schizophreniform Disorder |
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Definition
Criteria A met
Symptoms present for 1 to 6 months
No previous history of Schizophrenia
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Undifferentiated: Criteria not met for Paranoid, Disorganized or Catatonic
Residual
–Absence of prominent positive symptoms
–Positive symptoms may contain odd beliefs, unusual perceptual experiences
–Negative symptoms persist
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| Other Psychotic Classifications |
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Definition
Delusional Disorder
Shared Psychotic Disorder
Psychotic Disorder due to a General Medical Condition
Substance Induced Psychotic Disorder
Psychotic Disorder NOS
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Term
| Biological Basis of Schizophrenia |
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Definition
Hyperdopaminergic activity is associated with positive symptoms of Schizophrenia
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| Biological Basis of Schizophrenia |
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Definition
Drugs for Parkinson’s Disease have been known to cause drug-induced psychosis.
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| Biological Basis of Schizophrenia |
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Definition
Antithesis of Parkinson’s Disease (low levels of Dopamine) / Schizophrenia (high levels of Dopamine).
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| Pharmacological Effects of Typical Neuroleptics |
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Definition
Blocking of dopamine2 receptors-reduces positive symptoms
Blocking of:
–Acetylcholine—anticholinergic side effects
–Norepinephrine— sedation and hypotension
–Histamine– antiemetic effects and sedation
–Alpha– dizziness and lowered blood pressure
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Term
| Four Dopamine Pathways Involved with Untreated Schizophrenia |
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Definition
§Mesolimbic Dopamine Pathway: Hyper-dopamanergic Activity– causes positive symptoms
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| Four Dopamine Pathways Involved with Untreated Schizophrenia |
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Definition
§Mesocortical Dopamine Pathway: Low levels of dopamine—causing cognitive dysfunction and negative symptoms
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| Four Dopamine Pathways Involved with Untreated Schizophrenia |
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Definition
§Nigrostriatal Dopamine Pathway: Normal levels
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| Four Dopamine Pathways Involved with Untreated Schizophrenia |
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Definition
§Turberoinfundibular Pathway: Normal levels
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Term
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Definition
nMost effective antipsychotic, especially for severe schizophrenia.
nHelps with both the negative and positive symptoms of schizophrenia
nLater research has shown it to be effective with Disorganized Schizophrenia.
nLife threatening side-effect—agranulocytosis (decrease of white blood cells)
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Risperdal (Risperidone)
Risperdal Consta
Invega - Paliperidone |
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Definition
qIs as effective as Haldol in reducing positive symptoms but not as effective as Clozaril
nIs as effective as Clozaril reducing negative symptoms.
nHas been effective for autism and can reduce aggressive behavior with youth who have a conduct disorder.
nLow potential for EPS
nInvega produced from Risperidone’s active metabolite.
Invega comes in a sustained release formula
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nMolecule is structurally related to clozapine.
nAs effective as Haldol for positive symptoms
nTreats both positive and negative symptoms of Schizophrenia
nHas been successful in treating bi-polar disorder
nReleased two weeks ago: Symbiax
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nAs effective as Haldol in reducing positive symptoms
nThe reduction of negative symptoms have not been consistent according to current studies
nEPS symptoms were few
nShort half-life, requires b.i.d or t.i.d. dosing
nHas been useful for Bi-polar, Schizoaffective Disorder and drug-induced psychosis in Parkinson’s disease.
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nPartial Dopamine Agonist
nDopamine System Stabilizer (DSS)
nLower rate of sedation
nLower rate of weight gain
nMay have a stimulating effect (good for negative symptoms)
nTreats both positive and negative symptoms
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Term
| Positive Symptoms of Psychosis |
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Definition
CHADDDD
Catatonic Behavior
Hallucinations
Agitation
Delusions
Distortions or exaggerations
Disorganized speech
Disorganized behavior
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Term
| Anhedonia (negative symptom of Psychosis |
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Definition
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Definition
- Criteria A for schizo met
- Symptoms 1 day but no more than 30
- No history of schixophrenia
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Term
| Prognosis for Brief Psychotic Disorder is.... |
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Definition
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Pretty Damn Cool
Paranoid
Disorganized
Catatonic |
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| why is a symptom negative |
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Definition
| something is taken away from a person. |
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Definition
- Prominent delusions
- autitory hallucinations
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Definition
disorganized speech
disorganized behavior
flat or inappropriate affect |
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marked psychomotor disturmannce
MEE
Motoric immobility
Extreme negativism
Echolalia or echopraxia |
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During period of illness there is a Major Depressive, Manic or Mixed episode concurrent with positive symptoms of schizophrenia
TWO weeks of positive symptoms in the absense of the episodes
Major, Manic or Mixed symptoms through most of the illness |
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| Cost of schizophrenia in the US |
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Definition
| billions of dollars (but still less than Obamacare) |
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| Neuroleptics is also known as |
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Definition
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| Most widley used and least expensive drugs for treating psychosis |
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Definition
| Phenothiazines Antipsychotics |
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| Alcohol induced hallucinosis |
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Definition
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Term
| What is used to manage hallucinations and delusions caused by psychedelic agants? |
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Definition
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Term
| What can be used to treat nausea |
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Definition
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| what can be used for Pre-Op sedation |
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Definition
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Term
| The slides say this is used for premature ejaculation (careful) |
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Definition
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| Can be used to relieve sever itching (after premature...) |
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Definition
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| What are the 4 dopamine pathways? |
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Definition
lMake Me Now Trevor pathways
Mesolimbic
Mesocortical
Nigrostriatal
Turberoinfundibular |
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Term
| What does blocking the Mesolimbic pathway with Neuroleptic APs do? |
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Definition
Blocks dopamine -Relieves Delusions and Hallucinations.
Mesolimbic (a limb is a positive appendage) |
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| What does blocking the Mesocortical pathway with Neuroleptic APs do? |
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Definition
Blocking Dopamine Increases Cognitive Dysfunction and Negative Symptoms
Mesocortical (cort means cut which is negative and causes dysfuntion) |
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| What does blocking the Nigrostriatal pathway with Neuroleptic APs do? |
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Definition
Produces EPS
EPS = Evil People Say nigro |
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| What does blocking the Turberoinfundibular pathway with Neuroleptic APs do? |
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Definition
When dopamine is blocked prolactin secretion increases.
With Turbo lactin, the kid eats faster. |
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Term
| Parkinsonism is a group of nervous system disorder marked by |
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Definition
Muscular Rigidity
Tremors
Lack of facial expresssion
Akinesia (slow movement
Postural Abnormalities |
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Term
| Acute Drug Induced Akathisia |
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Definition
Basicly can't sit still
When I see A-cute girl named Akathisia I can't sit still. |
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Term
| Drug Induced Acute Dystonia |
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Definition
ABnormal positioning of head and neck
Spasms of the jaw
Imaired swallowing
Impaired Speaking or breathing
Thickened or slurred speach
Eyes deviate up or down
abnormal positioning of limbs or trunk
When I see A cute girl like princess DY-stonia I double take and quit breathing. |
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| Drug induced Tardive Dyskinesia |
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Definition
Abnormal, involuntary movements of tongue, jaw, trunk or extremeties
Tardives make me involuntarily throw up (tongue, jaw...) |
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Definition
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Definition
very expensive 6k per year
Nice CLOZ are expensive |
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Term
| This treatment requires weekly to biweekly blood tests for the first five months than monthly blood tests. |
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Definition
Clozaril (clozapine)
Magic Johnson wears nice clothes and needs frequent blood tests. |
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Term
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Definition
| When you risper, you are anxious so you can't sleep which gives you headaches which makes you an Evil Person S#$% |
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Definition
Zyprexa DOES
Diziness
Orthostatic hypotension
EPS is rare
Sedation |
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| What chris says about 75 flash cards |
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