Term
| Which of the following pathways or enzymatic actions result only in the production of prostaglandins? |
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Definition
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Term
| Cysteinyl Leukotrienes are responsible for: |
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Definition
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Term
| Cox-2 selective inhibitors act on the enzyme: |
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Definition
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Term
| Hustamine action causes asthma-like symptomes by binding to the histamine receptor subtype of : |
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Definition
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Term
| Allopurinol inhibitory action causes the following: |
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Definition
| Inhibition of neutrophil recruitment |
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Term
| High expression of ICAMs directly causes the following effects: |
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Definition
| Increased binding of leukocytes to endothelial cells |
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Term
| Colchicine action causes the following: |
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Definition
| Inhibition of neutrophil recruitment. |
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Term
| Arachidonic acid is released from phospholipids by |
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Definition
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Term
| What is the direct precursor of all leukotrienes? |
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Definition
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Term
| Regulation of inflammatory response by eicosanoids may prevent the transition from: |
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Definition
| Acute to chronic inflammation. |
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Term
| When a cell itself responds to the cytokines, it produces the cytokine, the cytokine is is acting in an/a: |
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Definition
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Term
| Which set of drugs are the front line agents in the therapy for transplantations |
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Definition
| Cyclosporine, azathioprine, glucocorticoids, and mycophenolate mefotil. |
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Term
Which of the following description is NOT an example of autoimmune disease?
A/ antibody to self antigen
B/ Immune complex disease
C/ T cell-mediated disease |
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Definition
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Term
Which of the following drugs is an inhibitor of dihydrofolate reductase?
A/ Methotrexate
B/ Dapsone
C/ Mercaptopurine
D/ Sulfadiazine |
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Definition
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Term
| Tacrolimus, like cyclosporine is a specifice lymphocyte signaling inhibitor, bloking the production of IL-2. Taclolimus is different from cyclosporin because: |
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Definition
| Tacrolimus bindfs to FKBP while cyclosporine binds to cyclophilin |
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Term
| What is the mechanism of action of allopurinol? |
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Definition
| Used in the treatment of gout to decreases concentration of uric acid. |
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Term
| Which of the following immunosuppressive agents is an example of a cytotoxic agent? |
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Definition
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Term
| In terms of imunosuppression, Azathioprine is considered to be a /an |
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Definition
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Term
| Immunosuppressive agents can intervene in preventing T cells activation and function by the following ways: |
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Definition
| Inhibition of gene expression and cell surface receptor function |
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Term
Of these lymphocyte signaling inhibitor, which one has no nephotoxicity?
a/ Tacrolimus?
b/ Cyclosporine?
c/ Sirolimus?
d/ None of the above? |
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Definition
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Term
| Vasodilation is best characterized by |
|
Definition
| Increased heat and redness |
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Term
| Glucocorticoids (prednisone) action cause: |
|
Definition
| Decreases in archidoinc acid secretion and decrease of phospholipase A2 action |
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Term
| Insulin dependent diabetes mellitus is an |
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Definition
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Term
| Epinephrine is a dug that is used to treat |
|
Definition
| Anaphylaxis and Histamine-related pahologies |
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Term
| Which of the following histamine receptor antagonists will cause the most sedation? |
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Definition
| First generation o fhistamine H1 receptor antagonist. |
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Term
| The structure of Methotrexate is very similar to the structure of : |
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Definition
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Term
| One of the possible side effects of ATG(Anti-thymocyte globuling) is |
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Definition
| Enhenced cytokine release from initially activated T cells |
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Term
| The enzyme responsible for converting hypoxanthine to uric acid is |
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Definition
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Term
| In CNS, histamine that react is |
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Definition
|
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Term
|
Definition
| vasoconstriction, vasodialation and platelet aggregation. |
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Term
| Isoprostanes do not cause |
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Definition
|
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Term
|
Definition
| More specific than other immunosuppressants |
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Term
Which one does not influence the specific gen expression:
Cycrosporine, Tacrolimus, sicrolimes or methotrexate? |
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Definition
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Term
|
Definition
Enhence IL-2
Inhibit proteins that stop cell division (A)
Enhance protien that stop cell divison |
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Term
| TNF immuno suppressants are good because |
|
Definition
| they are much more selective and more focused in their action. |
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Term
| Cyclosporine and colchine taken together: what happens? |
|
Definition
decrease colchine excretion in bile
and decrease colchine excretion in urine. |
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