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Final Exam Preparation
Pharmacology
36
Pharmacology
Professional
05/14/2013

Additional Pharmacology Flashcards

 


 

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Term
Which of the following pathways or enzymatic actions result only in the production of prostaglandins?
Definition
Cyclooxygenase Pathway.
Term
Cysteinyl Leukotrienes are responsible for:
Definition
Vasoconstriction
Term
Cox-2 selective inhibitors act on the enzyme:
Definition
Cyclooxygenase
Term
Hustamine action causes asthma-like symptomes by binding to the histamine receptor subtype of :
Definition
H1.
Term
Allopurinol inhibitory action causes the following:
Definition
Inhibition of neutrophil recruitment
Term
High expression of ICAMs directly causes the following effects:
Definition
Increased binding of leukocytes to endothelial cells
Term
Colchicine action causes the following:
Definition
Inhibition of neutrophil recruitment.
Term
Arachidonic acid is released from phospholipids by
Definition
A2
Term
What is the direct precursor of all leukotrienes?
Definition
LTA4
Term
Regulation of inflammatory response by eicosanoids may prevent the transition from:
Definition
Acute to chronic inflammation.
Term
When a cell itself responds to the cytokines, it produces the cytokine, the cytokine is is acting in an/a:
Definition
Autocrine manner
Term
Which set of drugs are the front line agents in the therapy for transplantations
Definition
Cyclosporine, azathioprine, glucocorticoids, and mycophenolate mefotil.
Term
Which of the following description is NOT an example of autoimmune disease?
A/ antibody to self antigen
B/ Immune complex disease
C/ T cell-mediated disease
Definition
Non of the above.
Term
Which of the following drugs is an inhibitor of dihydrofolate reductase?
A/ Methotrexate
B/ Dapsone
C/ Mercaptopurine
D/ Sulfadiazine
Definition
A-/ Methotraxate
Term
Tacrolimus, like cyclosporine is a specifice lymphocyte signaling inhibitor, bloking the production of IL-2. Taclolimus is different from cyclosporin because:
Definition
Tacrolimus bindfs to FKBP while cyclosporine binds to cyclophilin
Term
What is the mechanism of action of allopurinol?
Definition
Used in the treatment of gout to decreases concentration of uric acid.
Term
Which of the following immunosuppressive agents is an example of a cytotoxic agent?
Definition
Azathioprine
Term
In terms of imunosuppression, Azathioprine is considered to be a /an
Definition
Cytotoxic agent
Term
Immunosuppressive agents can intervene in preventing T cells activation and function by the following ways:
Definition
Inhibition of gene expression and cell surface receptor function
Term
Of these lymphocyte signaling inhibitor, which one has no nephotoxicity?
a/ Tacrolimus?
b/ Cyclosporine?
c/ Sirolimus?
d/ None of the above?
Definition
C/ Siroliums
Term
Vasodilation is best characterized by
Definition
Increased heat and redness
Term
Glucocorticoids (prednisone) action cause:
Definition
Decreases in archidoinc acid secretion and decrease of phospholipase A2 action
Term
Insulin dependent diabetes mellitus is an
Definition
T-cell mediated disease
Term
Epinephrine is a dug that is used to treat
Definition
Anaphylaxis and Histamine-related pahologies
Term
Which of the following histamine receptor antagonists will cause the most sedation?
Definition
First generation o fhistamine H1 receptor antagonist.
Term
The structure of Methotrexate is very similar to the structure of :
Definition
Folic acid
Term
One of the possible side effects of ATG(Anti-thymocyte globuling) is
Definition
Enhenced cytokine release from initially activated T cells
Term
The enzyme responsible for converting hypoxanthine to uric acid is
Definition
Xanthine oxidase
Term
In CNS, histamine that react is
Definition
H3
Term
Prostacyclins cause:
Definition
vasoconstriction, vasodialation and platelet aggregation.
Term
Isoprostanes do not cause
Definition
inflammation
Term
TNF and antibiotics are
Definition
More specific than other immunosuppressants
Term
Which one does not influence the specific gen expression:
Cycrosporine, Tacrolimus, sicrolimes or methotrexate?
Definition
Methotrexate
Term
What does sicrolimus do?
Definition
Enhence IL-2
Inhibit proteins that stop cell division (A)
Enhance protien that stop cell divison
Term
TNF immuno suppressants are good because
Definition
they are much more selective and more focused in their action.
Term
Cyclosporine and colchine taken together: what happens?
Definition
decrease colchine excretion in bile
and decrease colchine excretion in urine.
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