Term
| Polyene Macrolides produced by |
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Definition
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Term
| Method of action Polyene Macrolides |
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Definition
| Interact with sterols in cell membrane to from channels |
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Term
| Example of Polyene Macrolides |
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Definition
| Amphotericin B, Nystatin and Pimaricin |
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Term
| Amphotericin B mode of administration |
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Definition
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Term
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Definition
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Term
| Amphotericin B side effects |
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Definition
| nephrotoxic, acute side effects |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| 5-membered organic rings with 2 (imidazoles) or 3 (triazoles) nitrogen molecules |
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Term
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Definition
| Inhibit cytochrome P450 – interferes with ergosterol synthesis |
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Term
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Definition
| Ketoconazole, Clotrimazole, miconazole |
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Term
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Definition
| oral/topical usage Systemic mycoses, dermatophytosis, cutaneous candidiasis |
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Term
| Ketoconazole side effects |
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Definition
| hepatotoxicity, ↓testosterone & cortisol levels, nausea, vomiting, photosensitivity, rashes |
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Term
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Definition
| Fluconazole, Itraconazole, Voriconazole |
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Term
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Definition
| oral/IV Candidiasis (non-nutropenic), Cryptococcus, Coccidiomycosis |
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Term
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Definition
| rare allergic rxns, alopecia, throbocytopenia |
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Term
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Definition
| oral/IV Systemic mycosis, Aspergillus species |
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Term
| Itraconazole side effects |
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Definition
| rare allergic rxns, alopecia, throbocytopenia and gastrointestinal |
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Term
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Definition
| Invasive aspergillosis, esophogeal candidiasis, salvage therapy for S. apiospermum, Fusarium, blastomycosis, ?dematiaceous fungi |
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Term
| Voriconazole side effects |
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Definition
| transient visual disturbance,↑hepatic enzymes |
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Term
| Antimetaolite Drugs example |
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Definition
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Term
| 5-Fluorocytosine structure |
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Definition
| Fluorinated analog of cytosine |
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Term
| 5-Fluorocytosine method of action |
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Definition
| Inhibits DNA & RNA synthesis, Emergence of drug resistance – use in combination |
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Term
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Definition
| C. neoformans, other mycoses |
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Term
| 5-Fluorocytosine side effects |
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Definition
| bone marrow depression, hepatoxicity, gastrointestinal intolerance |
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Term
| Allylamines method of action |
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Definition
| Inhibit ergosterol biosynthesis via inhibition of squalene epoxiase enzyme |
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Term
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Definition
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Term
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Definition
| Oral/topical for Dermatophytes |
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Term
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Definition
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Term
| Echinocandins method of action |
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Definition
| Lipopeptides that inhibit glucan synthesis (inhibit fungal cell wall synthesis) |
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Term
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Definition
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Term
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Definition
| IV, Esophogeal candidiasis, salvage therapy for invasive aspergillosis |
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Term
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Definition
| no serious side effects reported |
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Term
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Definition
| Produced by Penicillium griseofulvum |
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Term
| Griseofulvin method of action |
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Definition
| Disrupts mitotic spindle via interaction with polymerized microtubules |
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Term
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Definition
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Term
| Griseofulvin side effects |
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Definition
| mild (nausea, diarrhea, skin eruptions, photosensitivity, etc) |
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Term
| Antifungal susceptibility testing for yeast |
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Definition
| broth macro/microdilution, colorimetric microdilution, agar macrofilution, agar diffusion |
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Term
| Antifungal susceptibility testing for mold |
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Definition
| colorimetric microdilution, macro/microdilution, agar macrodilutions, agar diffusion |
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