Term
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Definition
| Each individual receives 1 or 2 A alleles, B alleles, Cw alleles, DR alleles, 0, 1 or 2 DR345 alleles, and 0, 1 or 2 DQ alleles. One halotype from each parent. |
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Term
| Clinical significance of the HLA system |
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Definition
| used for organ transplant cross matches |
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Term
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Definition
| antibody screening via bead based/flow cytometry hybrid method, serology via ELISA and DNA methods |
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Term
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Definition
| parent antigen shares epitopes with sub antigens |
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Term
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Definition
| the observed halotype frequency is higher than the expected halotype frequency in a population |
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Term
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Definition
| when chromosomes are pulled apart during meiotic division, chromosomal breaks can occur at crossover sites, resulting in complementary exchange of genetic material |
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Term
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Definition
| an offspring receives one halotype from mother and one halotype from their father |
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Term
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Definition
| some antigens are more frequent in a certain population than others, can cause discrepancies in paternity testing |
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Term
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Definition
| not done in HLA labs that often, sent out to reference labs |
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Term
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Definition
| certain halotypes have higher frequency dependent on race, also associations and linkage disequilibrium |
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Term
| Determine the probability of finding compatible blood for patients with antibodies. |
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Definition
| Have to have 2 HLA matches to transfuse |
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