Term
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Definition
| Neutralizes acid (heartburn, gastritis, peptic ulcer disease) |
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Term
| aluminum hydroxide/magnesium hydroxide (Maalox) |
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Definition
| Neutralizes acid (heartburn, gastritis, peptic ulcer disease) |
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Term
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Definition
| competitive antagonist of H2 receptors on parietal cells (GERD, peptic ulcer disease) |
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Term
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Definition
| competitive antagonist of H2 receptors on parietal cells (GERD, peptic ulcer disease) |
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Term
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Definition
| proton pump inhibitor--irreversibly inactivates H+/K+ ATPase (GERD, peptic ulcer disease, gastrinomas including zollinger-ellison syndrome) |
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Term
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Definition
| aluminum salt of sulfated sucrose--forms protective barrier |
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Term
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Definition
| PGE1 analogue (prevent NSAID induced ulceration) |
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Term
| bismuth subsalicylate (pepto bismol) |
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Definition
| coats stomach, antibacterial activity, antidiurrhetic |
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Term
| dietary fiber (Psyllium--metamucil) |
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Definition
| bulk forming laxative, antidiurrhetic |
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Term
|
Definition
| stool surfactant agent--detergent |
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Term
| magnesium hydroxide (milk of magnesia) |
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Definition
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Term
|
Definition
| osmotic laxative (colonic cleansing prior to diagnostic and surgical procedures) |
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Term
|
Definition
| stimulant laxative (acute and chronic constipation, colonic cleansing with PEG prior to procedures) |
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Term
| anthraquinone derivatives (Senna--SennaKot) |
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Definition
| stimulant laxative (ex lax) |
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Term
|
Definition
| prokinetic agent--dopamine D2 receptor antagonist and partial 5-HT agonist (gastroparesis, reflux esophagitis, antiemetic) |
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Term
|
Definition
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Term
|
Definition
| anticholinergic antispasmodic (IBS) |
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|
Term
| sulfasalazine (azulfidine) |
|
Definition
| topical aminosalicylate, immunosuppresive (IBD, RA-non biological DMARD) |
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Term
|
Definition
| monoclonal antibody against TNF alpha (Crohn's, RA-biologic DMARD) |
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Term
|
Definition
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Term
|
Definition
| antiplatelet--irreversible COX inhibitor (MI, thrombosis) |
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|
Term
| dipyridamole (persantine) |
|
Definition
| antiplatelet--phosphodiesterase inhibitor, platelet adhesion inhibitor (thrombosis) |
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Term
|
Definition
| antiplatelet--irreversibly binds to ADP receptor (MI, stroke, vascular death) |
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|
Term
heparin (hep-lock)
enoxaparin sodium (lovenox) |
|
Definition
| anticoagulant--binds antithrombin III (venous/arterial thromboembolic disease, extracorporeal circulation, pregnancy, IV catheters) |
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Term
|
Definition
| binds heparin (heparin overdose) |
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|
Term
| warfarin sodium (coumadin) |
|
Definition
| anticoagulant--vit. K epoxide reductase inhibitor--inhibits factor II, VII, IX, X, protein C and S (venous/arterial thromboembolic disease, extracorporeal circulation, IV catheters) |
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Term
|
Definition
| anticoagulant--blocks thrombin (treatment for heparin-induced thrombocytopenia) |
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Term
|
Definition
| fibrinolytic--cleaves plasminogen to plasmin (thrombosis, MI) |
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Term
|
Definition
| fibrinolytic--cleaves plasminogen to plasmin (thrombosis, MI) |
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Term
|
Definition
| hemostatic--converts prothrombin to thrombin (hemophilia A) |
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Term
|
Definition
| hemostatic--converts prothrombin to thrombin (hemophilia B) |
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Term
|
Definition
| iron deficiency in microcytic anemias |
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Term
|
Definition
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|
Term
| vit. B12 (cyanocabalamin, hydroxocobalamin) |
|
Definition
| megaloblastic anemia, pernicious anemia |
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|
Term
| epoetin alfa (erythropoietin, EPO, Epogen, procrit) |
|
Definition
| growth and differentiation of erythrocytes (chronic anemias--AIDS or cancer) |
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Term
|
Definition
| growth and differentiation of neutrophils (neutropenics from chemo or HIV) |
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Term
| sargramostim (GM-CSF; leukine) |
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Definition
| growth and differentiation of granulocytes and macrophages (cancer patients or after bone marrow transplant) |
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Term
| oprelvekin (interleukin 11; neumega) |
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Definition
| growth and differentiation of megakaryocytes and platelets (thrombocytopenia in cancer patients) |
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Term
| deferoxamine mesylate (desferal) |
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Definition
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|
Term
| activated charcoal (charcoAid, liqui-char) |
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Definition
| non-specific chelator --limits absorption (toxin ingestion) --must be w/i 4hrs of ingestion |
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Term
|
Definition
| alcohol dehydrogenase inhitor (methanol/ethylene glycol intoxication) |
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Term
| hydroxocobalamin (cyanokit) |
|
Definition
| combines w/ cyanide to produce vit. B12 |
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Term
| pralidoxime, 2-PAM (protopam chloride) |
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Definition
| reactivates acetylcholinesterase (organophosphate/nerve antitoxin) --must be given immediately |
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Term
|
Definition
| metal chelator (severe lead poisoning) --nephrotoxic, chills, fever, N/V |
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Term
|
Definition
| metal chelator (lead, arsenic, mercury poisoning) |
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|
Term
| organophosphate insecticides/nerve agents |
|
Definition
| acetylcholinesterase inhibitor--SLUDGE, death w/ resp failure --treat w/ 2-PAM |
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Term
|
Definition
| windshield washer or paint remover--metabolized to formaldehyde causing CNS depression, blindness, metabolic acidosis--give bicarb and fomepizole |
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Term
|
Definition
| antifreeze--metabolized to oxalic acid causing hypocalcemia, CNS depression, renal crystals/oxalicaciduria--give Calcium and fomepizole |
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Term
|
Definition
| water supply--binds sulhydryl groups causing oxidative stress and disrupting proteins, causes rice water diarrhea, and garlic breath acutely, hyerkeratosis/exfoliative dermatitis chronically--give succimer |
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Term
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Definition
| paint chips or contaminated water--molecular mimicry of other metals and inhibits Hgb synth., causes hypochromic microcytic anemia, weak wrist and ankle extensors, encephalopathy, colic, gout--give succimer, dexamethasone for encephalopathy, can also give EDTA |
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Term
|
Definition
| contaminated fish and grain by fungicide--increases intra Calcium and binds metallothionein causing ataxia, blindness, deafness--give succimer |
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Term
|
Definition
| product of combustion--out competes O2 for heme binding and decreases dissociation of O2 from heme causing HA, dizziness, death--put in hyperbaric oxygen |
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Term
|
Definition
| present in smoke and industrial byproducts--binds cytochrome oxidase inhibiting ETC causing bitter almond breath, LOC, seizures, coma--give hydroxocobalamin (cyanokit) produces vit B12 in presence of CN- |
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Term
|
Definition
| filamentous silica in old building materials, causes pleural effusions and mesothelioma lung cancer 15 yrs post exposure |
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Term
|
Definition
| flame retardants, plasticizers, insulation, herbicides--causes chloracne |
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