Term
| cyclophosphamide (cytoxan) |
|
Definition
| alkylating agent CCNS (hodgkins, lymphoma, multiple myeloma, leukemia, adenocarcinoma of ovary, breast and lung, immunosuppresant) --activated in liver |
|
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Term
|
Definition
| alkylating agent CCNS (BRAIN TUMORS, hodgkins/non-hodgkins lymphoma, multiple myeloma) --lipid soluble |
|
|
Term
|
Definition
| alkylating agent CCNS (metastatic TESTICULAR and ovarian tumors, advanced bladder and lung cancer) --platinum containing, NEPHROTOXIC, OTOTOXIC |
|
|
Term
| methotrexate (rheumatrex) |
|
Definition
| antimetabolite folic acid analog CCS (leukemia, lymphoma, breast head neck carcinomas, osteosarcoma, bladder and gastric cancer, immunosuppresant, PSORIASIS, RA) |
|
|
Term
| mercaptopurine (purinethol) |
|
Definition
| antimetabolite purine analog CCS (acute lymphatic, acute myelogenous, and central nervous system leukemia, immunosuppresant) |
|
|
Term
|
Definition
| antimetabolite pyrimidine analog CCS on proliferating cells--thymidylate synthetase inhibitor (breast carcinoma, colon rectum stomach and pancreas cancers, immunosuppresant) |
|
|
Term
|
Definition
| antimetabolite pyrimidine analog CCS (acute non-lymphocytic and lymphocytic leukemia, chronic myelocytic leukemia, meningeal leukemia, immunosuppresant) |
|
|
Term
| daunorubicin hydrochloride (cerubidine) |
|
Definition
| anthracycline antibiotic--intercalates and binds DNA CCNS (acute nonlymphocytic leukemia and acute lymphocytic leukemia) --cardiotoxic |
|
|
Term
| doxorubicin hydrochloride (adriamycin) |
|
Definition
| anthracycline antibiotic--intercalates and binds DNA CCNS (lymphoma, leukemia, hodgkins, breast ovary testicle thyroid lung gastric carcinomas) --cardiotoxic |
|
|
Term
| vinblastine sulfate (velban) |
|
Definition
| vinca alkaloid--distrupt mitotic spindle CCS M phase (hodgkins lymphoma, kaposis sarcoma, testicular bladder lung carcinomas, brain tumors) --neurotoxic |
|
|
Term
| vincristine sulfate (vincasar PFS) |
|
Definition
| vinca alkaloid--distrupt mitotic spindle CCS M phase (acute leukemia, hodgkins/non-hodgkins lymphoma, breast carcinoma, bladder cancer) --neurotoxic |
|
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Term
|
Definition
| podophyllotoxin--topoisomerase inhibitor, DNA chain breaks CCS G2 phase (testicular gastric lung carinoma and leukemias) --alopecia |
|
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Term
|
Definition
| diterpene from taxus brevifolia--promotes microtubule assembly CCS G2 and M phase (metastatic ovarian and breast carcinoma, non-small cell lung carcinoma) --alopecia |
|
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Term
|
Definition
| glucocorticoid--binds cytosolic receptors and affect DNA, RNA and protein synth. CCS G1 phase, suppress lymphocytes and macrophages (breast carcinoma, leukemia and lymphoma, immunosuppresant) --iatrogenic cushings syndrome |
|
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Term
|
Definition
| nonsteroidal antiestrogen CCS G1 phase (BREAST cancer) --hot flashes, visual disturbances, hypercalcemia, vaginal bleeding, potential tumor promoting endometrial cancer |
|
|
Term
| imatinib mesylate (gleevec) |
|
Definition
| kinase inhibitor--Bcr-Abl protein tyrosine kinase inhibition, inhibits cell proliferation and induces apoptosis, CCS G1 phase (PHILADELPHIA chromosome pos. chronic myeloid leukemia, ALL, c-Kit (CD117) receptor pos. gastrointestinal stromal tumor) --joint pain, fluid retention, cramps, edema, rash |
|
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Term
|
Definition
| IgG1 monoclonal AB--binds extracellular domain of human epidermal growth factor receptor HER-2, downregulation of EGF receptor tyrosine kinase signaling, G1 cell cycle arrest (BREAST cancer in EGF-2 pos. tumors) |
|
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Term
|
Definition
| synthetic T4 (hypothyroidism) |
|
|
Term
|
Definition
|
|
Term
|
Definition
thionamide--inhibits iodination and coupling of iodotyrosines, type 1 deiodinase inhibitor
(hyperthyroidism) |
|
|
Term
|
Definition
| thionamide--inhibits iodination and coupling of iodotyrosines (hyperthyroidism) |
|
|
Term
|
Definition
| bisphosphonate (osteoporosis, Paget's Disease) |
|
|
Term
|
Definition
| bisphosphonate (osteoporosis, Paget's Disease) |
|
|
Term
|
Definition
| bisphosphonate (osteoporosis) |
|
|
Term
| zoledronic acid (relclast, zometa) |
|
Definition
| bisphosphonate (osteoporosis, hypercalcemia, Paget's Disease) |
|
|
Term
|
Definition
| bone estrogen receptor agonist (postmenopausal osteoporosis) |
|
|
Term
|
Definition
| osteoporosis, hypoparathyroidism |
|
|
Term
|
Definition
| decreases osteoclast activity and increases Ca excretion by kidney (hypercalcemia, Paget's Disease, osteoporosis) |
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