Term
|
Definition
| Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism, postpartum breast engorgement |
|
|
Term
|
Definition
| retard progression of osteoporosis + Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism, postpartum breast engorgement |
|
|
Term
|
Definition
| Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism |
|
|
Term
|
Definition
| Treat S/S of menopause & treatment of female hypogonadism |
|
|
Term
|
Definition
| affects release of FSH & LH. Causes capillary dilation, fluid retention, protein anabolism, thins the cervical mucus, inhibits ovulation, & protects the heart from atherosclerosis. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Treatment of acne and premenstrual dysphoric disorder (PMDD), relief of S/S of menopause |
|
|
Term
| Etonogestrel (Implanon, NuvaRing) |
|
Definition
| Contraceptive for women, being investigated for men |
|
|
Term
| Levonorgestrel (Mirena, Plan B) |
|
Definition
| Intrauterine Contraceptive, also used as morning after pill |
|
|
Term
| Medroxyprogesterone (Provera) |
|
Definition
| PO for amenorrhea, and palliation of certain cancers (injection) |
|
|
Term
| Norethindrone Acetate (Aygestin) |
|
Definition
| used in combo for contraceptives, or alone for amenorrhea |
|
|
Term
|
Definition
| contraceptive (most effective in combo) |
|
|
Term
|
Definition
| contraceptive and in fertility programs; treats amen |
|
|
Term
|
Definition
| Inhibits FSH & LH. Transforms the proliferative endometrium into a secretory endometrium. Prevents follicle maturation and ovulation. Inhibits uterine contraction. |
|
|
Term
| Estrogen Contraindications |
|
Definition
| vaginal bleeding, breast cancer or estrogen-dependent breast cancer, clot disorders, CVA, heavy smokers, hepatic dysfunction, metabolic bone disease, renal insufficiency. |
|
|
Term
| Progestins Contraindications |
|
Definition
PID, STDs, Endometriosis, pelvic surgery b/c the affects of vasculature of the uterus.
Caution in PTs w/ epilepsy, migranes, asthma, or cardic/renal dysfunction |
|
|
Term
| Drospirenone Contraindications |
|
Definition
| PT at risk for hyperkalemia due to renal disorders, liver disease, and adrenal dysfunctions. |
|
|
Term
|
Definition
| breakthrough bleeding, menstrual irregularities, dysmenorrhea, amenorrhea, changes in libido, fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema, nausea, vomiting, abdominal cramps, bloating, colitis, acute pancreatitis, cholestatic jaundice, hepatic adenoma |
|
|
Term
| Progestins Dermal Patch Side Effects |
|
Definition
| fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + skin irritaion |
|
|
Term
| Progestins Vaginal Gel Side Effects |
|
Definition
| fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + nervousness, breast enlargement, perineal pain |
|
|
Term
| Progestins IUD Side Effects |
|
Definition
| fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + abdominal pain, endometriosis, abortion, PID, expulsion of IUD |
|
|
Term
| PROTOTYPE: Estradiol Adverse Effects |
|
Definition
| Corneal changes, photosensitivity, peripheral edema, chloasma, hepatic adenoma, nausea, vomiting, abdominal cramps, bloating, breakthrough bleeding, changes in menstrual flow, dysmenorrhea, premenstrual-like syndrome |
|
|
Term
| PROTOTYPE: Norethindrone Acetate Adverse Effects |
|
Definition
| Venous thromboembolism, loss of vision, diplopia, migraine, rash, acne, chloasma, alopecia, spotting, amenorrhea, fluid retention, edema, increase in weight |
|
|
Term
| PROTOTYE: Raloxifene (Evista) |
|
Definition
| prevention and treatment of osteoporosis; increases bone mineral density w/out stimulating endometrium, reduces risk of breast cancer in post menopausal women with osteoporosis |
|
|
Term
|
Definition
| used as an antineoplastic agent for treatment of advanced breast cancer in post menopausal women with estrogen receptor-positive and estrogen receptor -unknown tumors |
|
|
Term
| Estrogen Receptor Modulators (Raloxifene & Toremifene) |
|
Definition
| stimulate some estrogen receptor sites and block others while limiting the adverse effects |
|
|
Term
| PROTOTYE SE: Raloxifene (Evista) |
|
Definition
| GI upset, nausea, vomiting, fluid imbalance, headache, dizziness, visual changes, mental changes, hot flashes, skin rash, edema, vaginal bleeding, venous thromboembolism, depression |
|
|
Term
|
Definition
| Directly stimulate follicles and ovulation or stimulate the hypothalamus to increase FSH & LH levels leading to ovarian follicular development and maturation of ova. |
|
|
Term
|
Definition
| stimulates spermatogenesis in men with low sperm counts |
|
|
Term
| PROTOTYPE SE: Clomiphene (Clomid) |
|
Definition
| Risk of multiple births and birth defects, ovarian overstimulation (abdominal pain, distention, ascites, plural effusion), headache, fluid retantion, nausea, bloating, uterine bleeding, ovarian enlargement, gynecomastia, febrile reactions, vasomotor flushing, visual changes, vomiting, breast tenderness |
|
|
Term
|
Definition
| Stimulate uterine contractions to stimulate labor (oxytocics) or induce abortion (abortifacients) |
|
|
Term
|
Definition
| beta2-adrenergic agonist, used as a uterine motility agent to relax the gravid uterus to prolong pregnancy. To prevent premature labor. |
|
|
Term
|
Definition
| acts like hypothalamic hormone oxytocin, stored in the posterior pituitary. Stimulate uterine contractions. |
|
|
Term
|
Definition
| Stimulate contraction of the uterus. Also stimulates the lacteal glands in the breast to contract, promoting milk ejection in lactation women. Prevention and treatment of uterine atony after delivery, important to prevent post partum hemorrhage. |
|
|
Term
|
Definition
| Uterine rupture, uterine spasm, uterine hypertonicity, postpartum hemorrhage, decreased fetal HR, nausea, headache, dizziness, ertotism, water intoxication with coma, arrythmias, HTN |
|
|
Term
|
Definition
| Used to evacuate uterine contents via intense uterine contractions |
|
|
Term
| Abortifacients Indications |
|
Definition
| Stimulates uterine activity, dislodge any implanted trophoblast, abd preventing implantation of any fertilized egg. Terminating pregnancy at 12-20 weeks. Controls post partum hemorrhage and uterine atony that does not respond to other therapy. |
|
|
Term
| Fertility Drugs Contraindications |
|
Definition
| Primary ovarian failure, thyroid or adrenal dysfunction, ovarian cysts, pregnancy, idiopathic uterine bleeding, breast feeding, thromboembolic disease, respiratory disease |
|
|
Term
| Abortifacients Contraindications |
|
Definition
| after 20 weeks from the last menstrual period, active PID, (acute cardiovascular, hepatic, renal, or pulmonary disease), during lactation, asthma, HTN, adrenal disease, acute vaginitis, scarred uterus |
|
|
Term
| Oxytocin Contraindications |
|
Definition
| chephalopelvic dysproportion, unfavorable fetal position, complete uterine atony, early pregnancy, coronary disease, HTN, previous cesarena births, hepatic or renal impairment |
|
|
Term
|
Definition
| abdominal cramping, heavy uterine bleeding, perforated uterus, uterine rupture, headache, nausea, vomiting, diarrhea, diaphoresis, backache, rash, paresthesia, hypotension, uterine or vaginal pain, chills, fever |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Estrogen Receptor Modulator Prototype |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| male sex hormone, testosterone is a primary natural androgen. Used for replacement therapy in hypogonadism (under developed testes) and to treat certain types of breast cancer. Increases retention of Nitrogen, Na, K, Phosphorus and decrease Ca. |
|
|
Term
|
Definition
| Responsible for puberty. Protein anabolism. Increase production of RBC. Block FSH & LH in women, prevention of post partum breast engorgement. |
|
|
Term
| Androgens Contraindication |
|
Definition
| During pregnancy and lactation, prostate or breast in men, liver dysfunction, cardiovascular disease |
|
|
Term
|
Definition
| acne, edema, hirsutism, deepening of the voice, oily skin and hair, weight gain, decrease in breast size, testicular atrophy, flushing, sweating, vaginitis, nervousness, emotional lability, headache, dizziness, sleep disorder, fatigue, rash, altered serum electrolytes, hepatocellular cancer |
|
|
Term
| Androgens Drug-Laboratory Test Interference |
|
Definition
| PT taking androgens, there may be decreased thyroid fxn and increased creatinine and creatinine clearance... results not associated with disease states. |
|
|
Term
|
Definition
|
|
Term
| Anabolic Steroids Idications |
|
Definition
| promote body tissue-building processes, reverse catabolic processes, increase Hgb and RBC mass. Treat anemias, certain cancers, angioedeme, promote weight gain and tissue repair, and protein anabolism |
|
|
Term
| Anabolic Steroids Prototype |
|
Definition
|
|
Term
| Anabolic Steroids Contraindications |
|
Definition
| presence of liver dysfunction, coronary disease, prostate or breast cancer in males |
|
|
Term
|
Definition
In prepubertal males have phallic enlargement, hirstutism, increased skin pigmentation (virilization).
Postpubertal males: inhibition of testicular fxn, gynecomastia, testicular atrophy, priapism, baldness, change in libido.
Women: hirstutism, hoarseness, deepening of the voice, clitoral enlargement, baldness, menstrual irregularities.
General: Serum electrolyte changes, liver dysfunction, insomnia, weight gain |
|
|
Term
| Drugs for treating penile erectile dysfunction PROTOTYPE |
|
Definition
| Sildenafil (Viagra, Revatio) |
|
|
Term
|
Definition
| increases nitrous oxide lvls in the corpus cavernosum activating the enzyme zGMP which causes smooth muscles relaxation allowing the flow of blood into the corpus cavernosum.Also approved for treatment of pulmonary arterial HTN. |
|
|
Term
| Sildenafil Contraindications |
|
Definition
| anatomical obstruction or condition that might predispose to priapism, with penile implants, bleeding disorders, CAD, active peptic ulcer, retinitis pigmentosa, optic neuropathy, hypotension, severe HTN, congenital prolonged QT interval, severe hepatic and renal disorders. |
|
|
Term
|
Definition
| priapism, fibrosis, rash, headache, flushing , dyspepsia, UTI, diarrhea, dizziness, possible optic neuropathy, possible VIII cranial nerve toxicity, loss of hearing |
|
|
