Term
What is considered optimal and high level for the following:
LDL
Total Cholesterol
HDL |
|
Definition
1) 0-100mg/dL; 130-159mg/dL
2) 0-200mg/dL; 200-239mg/dL
3) 0-40mg/dL; 60+mg/dL |
|
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Term
| What are major risk factors that modify LDL goals other than LDL |
|
Definition
1) 1) cigarette smoking
- HTN/use of anti-HTN drug
- low HDL
- FHx of premature CHD (M = 0-55; F = 0-65yrso)
- age (M = 45+yrso; F = 55+yrso) |
|
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Term
| When should the Framinham Point Score of CHD Risk be assessed? |
|
Definition
| 1) if there are 2+ risk factors for CHD other than LDL levels |
|
|
Term
| What are the components to the Framingham Point CHD Risk Assessment? |
|
Definition
1) age
2) total cholesterol
- smoker status
- HDL level
- systolic BP
*evaluated to determine 10-yr risk of CHD* |
|
|
Term
What score on the Framingham CHD Risk Assessment is associated with:
0-5% risk 10yrs
0-10% risk 10yrs
20+% risk 10yrs |
|
Definition
1) M=9; F=17
2) M=12; F=20
3) M=15; F=23 |
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|
Term
What is the LDL goal for the following 10yr risk category:
20+%
10-20%
0-10% |
|
Definition
|
|
Term
What is the LDL level for the following 10yr risk category for initiating behavioral changes vs drug therapy:
20+%
10-20%
0-10% |
|
Definition
1) 100+; 130+
2) 130+; 130+
3) 160+; 190+ |
|
|
Term
| What are the TLC lifestyle changes if LD is above goal |
|
Definition
- TLC diet: sat fat 0-7% of calories; cholesterol 0-200mg/d; soluble fiber
- weight management
- increased physical activity |
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|
Term
What are hte major s/e of the following drug class:
statin |
|
Definition
- myopathy
- increased liver enzymes |
|
|
Term
What are hte major s/e of the following drug class:
bile acid sequestrants |
|
Definition
- GI distress
- constipation
- decreased absorption of other drugs |
|
|
Term
What are hte major s/e of the following drug class:
nicotinic acid |
|
Definition
- flushing
- hyperglycemia
- hyperuricemia
- upper GI distress
- hepatotoxicity |
|
|
Term
What are hte major s/e of the following drug class:
fibric acids |
|
Definition
- dyspepsia
- gallstones
- myopathy |
|
|
Term
What is the effect of the following drug class on the LDL/HDL/TG levels:
statins |
|
Definition
|
|
Term
What is the effect of the following drug class on the LDL/HDL/TG levels:
bile acid sequestrants |
|
Definition
1) dec
2) inc
3) no change/inc |
|
|
Term
What is the effect of the following drug class on the LDL/HDL/TG levels:
nicotinic acid |
|
Definition
|
|
Term
What is the effect of the following drug class on the LDL/HDL/TG levels:
fibric acids |
|
Definition
1) dec (inc w/ high TG)
2) inc
3) dec |
|
|
Term
What is the drug class and typical starting dose for the following type of drug:
pravastatin
simvastatin |
|
Definition
1) statin; 20-40mg qd
2) statin; 20-80mg qd |
|
|
Term
What is the drug class and typical starting dose for the following type of drug:
cholestyramine
colestipol |
|
Definition
bile acid sequestrants
1) 4-16g qd
2) 5-20g qd |
|
|
Term
What is the drug class and typical starting dose for the following type of drug:
niaspan |
|
Definition
|
|
Term
What is the drug class and typical starting dose for the following type of drug:
gemfibrozil
fenofibrate |
|
Definition
fibric acids
1) 600mg BID
2) 200mg qd |
|
|
Term
What are absolute contraindications in pts for use of the following drug class:
statins |
|
Definition
| 1) active/chronic liver disease |
|
|
Term
What are absolute contraindications in pts for use of the following drug class:
bile acid sequestrants |
|
Definition
- dysbeta-lipoproteinemia
- TG 400+ |
|
|
Term
What are absolute contraindications in pts for use of the following drug class:
nicotinic acid |
|
Definition
- chronic liver disease
- severe gout |
|
|
Term
What are absolute contraindications in pts for use of the following drug class:
fibric acids |
|
Definition
- severe renal disease
- severe hepatic disease |
|
|
Term
| What are the criteria for metabolic syndrome |
|
Definition
any three of the following:
1) abd obesity: M 40+in; F 35+in
2) TG 150+
3) HDL: M 0-40; F 0 -50
4) BP: 130/85+
5) fasting glucose 110+ |
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|
Term
| What are the levels for Triglycerides that are considered normal vs high |
|
Definition
|
|
Term
| Describe tx of elevated TG (150+) |
|
Definition
- reach LDL goal
- intensify weight management
- increase physical activity
- if TG200+ after LDL goal reached, set secondary goal for non-HDL cholesterol to 30mg/dL higher than LDL goal |
|
|
Term
| What are methods to lower TG to prevent pancreatitis w/ TG500+ |
|
Definition
- very low-fat diety
- weight management and physical activity
- fibrate/nicotinic acid
- return to LDL therapy once TG=0-500 |
|
|
Term
| Describe treatment of low HDL cholesterol |
|
Definition
- first reach LDL
- intensify weight management and inc physical activity
- TG 200-500, achieve non-HDL goal
- TG0-200, consider nicotinic acid/fibrate |
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