Term
| What are predictors for a positive response to depression treatment? |
|
Definition
- lower baseline severity
- higher education level
- higher income
- private insurance
- higher mental and physical functioning
- shorter episode of depression |
|
|
Term
| What is the major metabolism pathway for TCAs? |
|
Definition
|
|
Term
| What are TCAs not preferred compared to SSRI |
|
Definition
- associated w/ higher risk of CV events (QTc prolongation)
- highly lethal in OD
- inc s/e profile |
|
|
Term
| What are the effects of TCA overdose? |
|
Definition
- respiratory depression
- cardiac arrhythmias (QTc prolongation is highly suggestive of TCA OD)
- hypothermia
- seizures
- hallucinations
- hypertension |
|
|
Term
| Which SSRIs are most commonly associated with drug-drug interactions |
|
Definition
- fluoxetine; paroxetine
- cause inhibition of P450 system |
|
|
Term
| What is the MOA of mirtazapine |
|
Definition
| - blocking alpha-2 adrenergic receptors |
|
|
Term
| What isthe use of Hypericum perforatum (St. John's wort? |
|
Definition
| - alternative to prescription antidepressants |
|
|
Term
| What types of SSRI/SNRI is the discontinuation syndrome most common? |
|
Definition
| 1) paroxetine and venlafaxine |
|
|
Term
| What are hte symptoms of SSRI discontinuation syndrome |
|
Definition
- anxiety
- ataxia
- diarrhea
- dizziness/vertigo/faintness
- fatigue
- h/a
- insomnia
- irritability
- nausea
- paresthesias (electric schocks)
- tremor
- visual disturbances
- vomiting |
|
|
Term
| What are the major risk factors for depression treatment failure |
|
Definition
- addiction
- coexisting medical illness
- coexisting psychiatric illness
- cognitive impairment
- fhx of failure
- hx of physical/sexual abuse
- inadequate dose
- inadequate duration
- incorrect dx
- severity of depression
- tx nonadherence |
|
|
Term
| What are the symptoms of serotonin syndrome |
|
Definition
- akathisia
- anxiety
- clonus
- delirium
- dilated pupils
- muscular rigidity
- renal failure
- rhabdomyolysis
- seizures
- sweating
- tachycardia
- tremor |
|
|
Term
| What was the finding in Practitioner Empathy and the Duration of the Common Cold? |
|
Definition
1) perfect CARE score resulted in shorter duration of cold and larger increase in IL-8 levels
- clinician empathy, as perceived by patients, predicts duration and severity of illness |
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