• Acetyl Transferase
• Lactonase

Acetylgroup

• 2'
• 2''
• 3
• 6'

 "there are two twos, so one of which is 2''. 

AMP

• 2''
• 4'
• 4''

"2²  = 4"

(P)

• 3'

KatG + Manganase

"Kat deeley smokes nicotine mg"

Mycotic acid inhibitor

1. KatG activates INH
2. Acylation of NADH poisoning InhA.

Refer to chart:

Increases <+>, decreases resistance by efflux

1. di-nitro (piperizine) ring at 7 or
2. bicyclic ring at 7 (better)

Refer to chart:

Increases <+> and increased hydrophobic

Refer to chart:

Increases and decrease water solubility (stay hydrated)

1 N cyclopentane (pyrolidine) at 7

Refer to chart:

Increases lipophilicity, t1/2, phototoxicity

Refer to chart:

Increases, t1/2,

1. Methoxy substituent at 8

Nephrotoxoc

ototoxic