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F09 Oral Path 1a
Salivary Gland Pathology
64
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Professional
08/27/2009

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Term
A MUCOCELE is a common lesion due to spillage of mucin often resulting from local trauma.
Definition
A ___ is a common lesion due to spillage of mucin often resulting from local trauma.
Term
False! Mucoceles are NOT true cysts; they have no epithelial lining.
Definition
T/F: Mucoceles are true cysts with epithelial lining.
Term
MUCOCELES and RANULAS are dome-shaped with a bluish translucent hue due to mucous spillage.
Definition
____ and ____ are dome-shaped with a bluish translucent hue due to mucous spillage.
Term
MUCOCELES are characteristically fluctuant.
Definition
___ are characteristically fluctuant.
Term
The LOWER LIP is the most common site (75%) for a mucocele. It is rare on the upper lip.
Definition
Where is the most common site (75%) for a mucocele?
Term
True!!
Definition
T/F: Tumors are not unusual on the upper lip, but distinctly uncommon in the lower lip.
Term
RANULA is a mucocele in the FOM.
Definition
___ is a mucocele in the FOM.
Term
A RANULA may be mistaken for a dermoid cyst in the FOM.
Definition
A ___ may be mistaken for a dermoid cyst in the FOM.
Term
A SALIVARY DUCT cyst is a true cyst lined by epithelium found most frequently in the FOM, buccal mucosa and lips.
Definition
A ___ ___ cyst is a true cyst lined by epithelium found most frequently in the FOM, buccal mucosa and lips.
Term
SIALOLITHIASIS
Definition
____ are calcified structures within salivary ducts. It is most common in the submandibular and less common in the parotid gland.
Term
False! Vice versa, due to the long path of the Wharton's duct and the thicker, mucoid secretions in that gland
Definition
T/F: Sialolithiasis are more commonly found in the parotid gland than the submandibular gland.
Term
Sialadenitis
Definition
___ is inflammation of the salivary glands.
Term
Staph aureus
Definition
Which bacteria usually causes Sialadeitis by retrograde spreading?
Term
Sialadenitis
Definition
___ is treated with antibiotics, rehydration and removal of obstruction.
Term
Cheilitis Glandularis
Definition
___ ___ is a rare inflammatory condition of minor salivary glands in the lips.
Term
1. Actinic (sun) damage / 2. Tobacco / 3. Syphilis / 4. Poor hygiene / 5. Heredity
Definition
Name 3 of the 5 etiologic factors of Cheilitis Glandularis.
Term
Actinic
Definition
___ = sun damage.
Term
Lower lip
Definition
Where is cheilitis glandularis characteristically found?
Term
cheilitis glandularis
Definition
Clinical features of ___ ___ include: openings of ducts are inflamed and dilated, swelling and eversion of lip due to hypertrophy and inflammation of glands.
Term
Sjogren's syndrome
Definition
The principal oral symptom of ___ ___ is xerostomia. It manifests as diffuse, firm enlargements of the major salivary glands -- usually bilateral.
Term
sjogren's syndrome
Definition
Anti-SS-A and Anti-SS-B are two nuclear autoantibodies in ___ ___.
Term
lymphocytes
Definition
Blue dotted cells in a histological image = ____.
Term
Sjogren's syndrome
Definition
Patients with ___ ___ have an increased risk for lymphoma by 40x.
Term
Sialadenosis
Definition
___ is the unusual noninflammatory disorder characterized by asymptomatic enlargement of the parotid gland. It is almost always associated with an underlying systemic problem.
Term
False! It is usually bilateral.
Definition
T/F: Sialadenosis is not usually bilateral.
Term
Nerotizing Sialometaplasia
Definition
___ ___ is an uncommon, locally destructive inflammatory condition.
Term
Necrotizing sialometaplasia
Definition
___ ___ mimics squamous cell carcinoma both clinically and microscopically.
Term
Posterior palate (>75%)
Definition
Where is necrotizing sialometaplasia most commonly found?
Term
Necrotizing sialometaplasia
Definition
___ ___ initially presents as a non-ulcerated swelling, often associated with pain or paresthesia. Within 2-3 weeks, necrotic tissue sloughs out, leaving a crater-like ulcer 1-5mm in diameter.
Term
True! But necrotizing sialometaplasia is most commonly found on the palate.
Definition
T/F: Squamous cell carcinoma is not usually found on the palate.
Term
Parotid (64-80%) followed by minor salivary glands (9-23%)
Definition
Which gland are salivary gland tumors most commonly found in?
Term
True!! Parotid tumors are often benign, submandibular gland tumors are 37-45% malignant and sublingual gland tumors are rare, but 70-90% are malignant.
Definition
T/F: The bigger the gland (parotid) the better chance that a tumor is benign.
Term
Palate (42-54%) Most on the posterior lateral hard or soft palate... Lips #2
Definition
Where are minor salivary gland tumors most commonly found?
Term
monomorphic adenoma
Definition
Canalicular adenoma and basal cell adenoma are ___ ___.
Term
Canalicular adenoma
Definition
___ ___ are found almost exclusively in minor salivary glands. They are slow growing and painless and >75% are found in the upper lip.
Term
Parotid gland... tumor cells have a basaloid appearance -- cells appear to be standing up
Definition
Basal cell adenoma is primarily found in which gland?
Term
Warthin's tumor (papillary cystadenoma lymphomatosum) is also found in males > females.
Definition
Which tumor is found in smokers 8x more than non-smokers, almost exclusively in the parotid gland bilaterally?
Term
Papillary cystadenoma lymphomatosum
Definition
____ ____ ____ is Warthin's tumor.
Term
Pleiomorphic adenoma
Definition
___ ___ is a benign mixed tumor which is the most common salivary neoplasm.
Term
mucoepidermoid carcinoma
Definition
____ ___ looks like a mucocele and is the most common salivary gland malignancy.
Term
mucoepidermoid carcinoma
Definition
____ ____ is the most common malignant salivary gland tumor in children. It may arise within jaws from odontogenic ep of dentigerous cysts.
Term
mucoepidermoid carcinoma -- Low-grade tumors have good prognosis
Definition
___ ___ is a malignancy of a muxture of mucus-producing cells and epidermoid or squamous cells.
Term
Acinic cell adenocarcinoma
Definition
___ ___ ___ is a malignancy with serous acinar differentiation. It is most common in the parotid gland and has a better prognosis than other tumors.
Term
parotid gland -- it has a better prognosis than other tumors
Definition
Where is Acinic cell adenocarcinoma found most commonly?
Term
Adenoid cystic carcinoma
Definition
___ ___ ___ was originally called a cylindroma. It is found most commonly in minor salivary glands of palate. Pain is a common and important early finding.
Term
adenoid cystic carcinoma
Definition
___ ___ ___ has a tendency to show perineural invasion, which corresponds to the pain associated with early detection.
Term
adenoid cystic carcinoma -- usually a slowly growing mass
Definition
Which carcinoma presents as swiss cheese histologically?
Term
60% on hard/soft palate
Definition
Where is polymorphous low-grade adenocarcinoma most commonly found?
Term
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma
Definition
Peineural invasion is common in which two carcinomas?
Term
carcinoma ex pleomorphic adenoma
Definition
Which neoplasia arises from preexisting pleiomorphic adenoma?
Term
Palate (PAM PM) Pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, polymorphous low grade adenocarcinoma and monomorphic adenoma
Definition
Pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, polymorphous low grade adenocarcinoma and monomorphic adenoma are most frequently found where?
Term
Parotid gland
Definition
Pleomorphic adenoma, wathin's tumor, basal cell adenoma, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma and carcinoma ex pleomorphic adenoma are most commonly found in which gland?
Term
upper lip
Definition
Canalicular adenoma, salivary duct cysts and pleomorphic adenoma are found most commonly where?
Term
lower lip
Definition
Mucoceles, mucoepidermoid carcinoma and pleomorphic adenoma are found where?
Term
D. It is NOT a true cyst w/an epithelial lining
Definition
Which of the following is NOT true for a mucocele:
a. Mucus extravasation phenomenon
b. Common lesion due to spillage of mucin
c. Often result of local trauma
d. It is a true cyst with an epithelial lining
Term
Lower lip
Definition
The most common site for a mucocele is the ________.
Term
D. All of the above!
Definition
Which of the following is true for a ranula?
a. Blue, dome-shaped, fluctuant swelling
b. Larger than mucoceles
c. Most common location is the floor of the mouth
d. All of the above
Term
C. Chelitis glandularis
Definition
Which of the following has the potential for malignant transformation?
a. Chronic sialadentitis
b. Sialadenosis
c. Chelitis glandularis
Term
Xerostomia and xeropthalmia (dry mouth / dry eyes)
Definition
Primary Sjogren's syndrome is defined as ____ and ____.
Term
Palate
Definition
The most common location for necrotizing sialometaplasia is the ____.
Term
Palate
Definition
The most common intraoral location for salivary gland tumors is the ____.
Term
Chelitis glandularis
Definition
A 45 year old man presents with the chief complaint of swelling and eversion of the lower lip. His history is significant for excessive sun exposure and he is also a chain smoker. What is most likely the diagnosis?
Term
Sialothiosis ( Sialolith)
Definition
A 50 year ols woman presented with a firm, hard nodule in the floor of the mouth. Based on the clinical and radiographic features, what is the diagnosis?
Term
D. All of the above!
Definition
Which of the following statements is true about Sjogren's syndrome:
a. Main oral symptoms is xerostomia
b. Lymphatic infiltration of the glands with destruction
c. Biopsy of the minor salivary glands of lower lip confirms the diagnosis
d. All of the above
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