Term
| acetyl salicylic acid [Aspirin] |
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Definition
| MoA: oral IRREVERSIBLE inhibition of COX-1 & COX-2; Toxicity: GI, hepatic, hypersensitivy, Reyes syndrome, salicylism; Indications: analgesic, antipyretics, antiinflammatory, antirheumatic |
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Term
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Definition
| derivative of salicylic acid, not a true salicylate; MoA: oral REVERSIBLE inhibition of COX-1 & COX-2; Toxicities: GI mild, HA, renal, hypersensitivity; Indications: analgesic, antiinflammatory, weak antipyretic |
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Term
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Definition
| acetic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicities: GI severe, gestation prolongation, renal, CNS: HA & aggravated depression; Indications: RA, osteoarthritis, tocolytic agent; NOT for JUVENILE RA!!! |
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Term
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Definition
| acetic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor but with MORE COX-2 selectivity; Toxicity: GI: less severe than indomethacin; Indications: RA, osteoarthritis, postoperative anaglesia |
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Term
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Definition
| acetic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicity: GI, CNS: dizziness & HA; Indications: RA, osteoarthritis, analgesia/dysmenorrhea |
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Term
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Definition
| MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicity: GI, CNS: HA, CAUTION: ANAPHYLACTOID RXNS!!!; Indications: RA, JUVENILE RA, osteoarthritis |
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Term
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Definition
| acetic acid derivative; MoA: oral & IM reversible COX-1 & COX-2 inhibitor; Toxicities: GI, CNS: HA; Indications: moderately severe acute pain |
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Term
| ibuprofen [Motrin, Advil] |
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Definition
| propionic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicity: LESS GI than ASPIRIN or INDOMETHACIN, OCULAR DISTURBANCES, HYPERSENSITIVITY: rash/dermatitis, AVOID during pregnancy or breast-feeding; Indications: RA, osteoarthritis, analgesia, dysmenorrhea, fever |
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Term
| naproxen [Anaprox, Aleve] |
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Definition
| propionic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicities: GI: < than indomethacin, CNS: HA < than indomethacin, Hypersensitivity; Indications: RA, JUVENILE RA, osteoarthritis, analgesia, dysmenorrhea |
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Term
| ketoprofen [Actron, Orudis] |
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Definition
| propionic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor; Toxicities: GI: 30% of pts, CNS: HA; Indications: RA, osteoarthritis, analgeisa, dysmenorrhea |
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Term
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Definition
| propionic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor, GIVE ONCE DAILY; Toxicity: GI; Indications: RA, osteoarthritis |
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Term
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Definition
| enolic acid derivative; MoA: oral reversible inhibition of COX-1 and COX-2; Toxicity: GI; Indications: RA, osteoarthritis |
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Term
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Definition
| enolic acid derivative; MoA: oral reversible COX-1 & COX-2 inhibitor WITH MORE COX-2 SELECTIVITY; Toxicity: GI; Indications: osteoarthritis |
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Term
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Definition
| alkanone; MoA: oral reversible COX-1 & COX-2 inhibitor with MORE COX-2 SELECTIVITY, ACTIVATED BY LIVER; Toxicity: GI, CNS: HA; Indications: RA, osteoarthritis |
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Term
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Definition
| MoA: COX-2 inhibitor ONLY; Toxicity: minor disturbances - GI, CNS, respiratory, rash, sulfonamide allergy, possible cardiovascular side effects; Indications: osteoarthritis, RA, dysmenorrhea, acute pain, familial adenomatous polyposis |
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Term
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Definition
| para-aminophenol derivative; MoA: analgesia by elevation of pain threshold probably by weak inhibition of COX-1 & COX-2, antipyresis by action on hypothalamic heat-regulating center; Toxicity: minor: hypersensitivity (rash), potential hepatotoxicity & nephrotoxicity; Indications: antipyretic & analgesic, osteoarthritis for relief of pain |
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