Term
Alzheimers Disease (AD)
Symptoms |
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Definition
- Impaired thought process
- Memory loss
- Neuropsychiatric symptoms (hallucinations)
- Inability to perform routine tasks of daily living
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Term
Alzheimers Disease (AD)
Pathology |
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Definition
- Degeneration of the cholinergic neurons
- Presence of neuritic plaques and neurofibrullary tangles
- Irreversible damage, no cure
- Degeneration begins in hippocampus and moves to cerebral cortex.
- 90% Acetylcholine loss
- Mental loss of function (cerebral cortex) and memory formation
- Neurofibrillary tangles inside neuron cells contain abnormal tau protein
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Term
Alzheimers Disease
Increased Risks |
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Definition
- Increased age
- Genetic codes for ApoE4, if have ApoE2 than considered a protectant
- Elevated levels of homocysteine
- Elevated ERAB (endoplasmic reticulum associated binding protein), ERAB plus beta-amyloid (neurotic plaques) creates toxic effects
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Term
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Definition
| Symtom associated with Alzheimers Disease where the patient's symptoms increase in the evening |
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Term
Alzheimer's Disease
Diagnosis |
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Definition
Age
Clinical Evaluation
Exclusion |
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Term
Alzheimer's Disease
Types of drugs |
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Definition
1. Cholinerterase Inhibitors (mild to moderate)
2. NMDA Antagonists (moderate to severe) |
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Term
| Cholinerase Inhibitors to treat Alzheimer's Disease |
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Definition
Prevent ACh breakdown, more ACh in system
1. Donepezil (Aricept)
2. Rivastigmine (Exelon)
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Term
| What are the adverse effects of the cholinesterase Inhibitors used to treat Alzheimer's Disease |
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Definition
1. Nausea
2. Vomiting
3. Dyspepsia
4. Bronchiocontriction |
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Term
| What is the first line Cholinesterase Inhibitor for treating Alzheimer's Disease |
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Definition
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Term
| What drug for treating Alzheimer's is available in a patch? |
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Definition
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Term
| Why is using Aricept and Exelon a controindication for patients with COPD? |
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Definition
| Because an adverse effect of the drug is brochiocontriction. |
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Term
| What are drugs that are controindicated when using Aricept and Exelon? |
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Definition
Antihistamines
Tricyclic antidepressants
Conventional antipsychotics |
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Term
| What drugs are older AD drugs? |
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Definition
Donepezil (Aricept)
Rivastigmine (Exelon) |
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Term
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Definition
NMDA Antagonists,
Memantine (Namenda) |
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