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Exam #2
Study materials for exam
16
Pharmacology
Undergraduate 3
03/03/2012

Additional Pharmacology Flashcards

 


 

Cards

Term

Alzheimers Disease (AD)

Symptoms

Definition

- Impaired thought process

- Memory loss

- Neuropsychiatric symptoms (hallucinations)

- Inability to perform routine tasks of daily living

 

 

 

 

Term

Alzheimers Disease (AD)

Pathology

Definition

- Degeneration of the cholinergic neurons

- Presence  of neuritic plaques and neurofibrullary tangles

- Irreversible damage, no cure

- Degeneration begins in hippocampus and moves to cerebral cortex.

- 90% Acetylcholine loss

- Mental loss of function (cerebral cortex) and memory formation

- Neurofibrillary tangles inside neuron cells contain abnormal tau protein


Term

Alzheimers Disease 

Increased Risks

Definition

- Increased age

- Genetic codes for ApoE4, if have ApoE2 than considered a protectant

- Elevated levels of homocysteine

- Elevated ERAB (endoplasmic reticulum associated binding protein), ERAB plus beta-amyloid (neurotic plaques) creates toxic effects 

 

Term
Sundowning
Definition
Symtom associated with Alzheimers Disease where the patient's symptoms increase in the evening
Term

Alzheimer's Disease

Diagnosis

Definition

Age

Clinical Evaluation

Exclusion

Term

Alzheimer's Disease 

Types of drugs

Definition

1. Cholinerterase Inhibitors (mild to moderate)

2. NMDA Antagonists (moderate to severe)

Term
Cholinerase Inhibitors to treat Alzheimer's Disease
Definition

Prevent ACh breakdown, more ACh in system

1. Donepezil (Aricept)

2. Rivastigmine (Exelon)


Term
What are the adverse effects of the cholinesterase Inhibitors used to treat Alzheimer's Disease
Definition

1. Nausea

2. Vomiting

3. Dyspepsia

4. Bronchiocontriction

Term
What is the first line Cholinesterase Inhibitor for treating Alzheimer's Disease
Definition
Donepezil (Aricept)
Term
What drug for treating Alzheimer's is available in a patch?
Definition
Rivastigmine (Exelon)
Term
Why is using Aricept and Exelon a controindication for patients with COPD?
Definition
Because an adverse effect of the drug is brochiocontriction.
Term
What are drugs that are controindicated when using Aricept and Exelon?
Definition

Antihistamines

Tricyclic antidepressants

Conventional antipsychotics

Term
What drugs are older AD drugs?
Definition

Donepezil (Aricept)

Rivastigmine (Exelon)

Term
What are newer AD drugs?
Definition

NMDA Antagonists,

Memantine (Namenda)

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