Term
| What is the drug treatment for BPH? |
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Definition
| Finasteride (Proscar, Propecia) - Blocks conversion of testerone to DHT. |
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Term
| What is the drug treatment of Impotence? |
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Definition
| Viagra - helps with pulmonary arterial hypertension (Vasodilation mediated by Nitric Oxide, Reduces pulmonary arterial pressure and pulmonary vascular resistance) |
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Term
| What is the drug treatment for hyperthyroidism? |
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Definition
| Propylthiouracil (PTU) - Blocks hormone synthesis by inhibiting conversion of T4 to T3 in peripheral circulation. |
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Term
| What is the drug treatment for hypothyroidism? |
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Definition
| Levothyroxine Na (Synthyroid) - Exogenous replacement of thyroid hormone to achieve euthyroid levels and normalize metabolism. |
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Term
| What is the drug treatment for SIADH.. Although it is not the first choice drug? |
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Definition
| Demeclocycline (Declomycin) - Interferes with renal response to ADH and Tx of persistent SIADH. SE: Photosensitivity and Teeth Stain. |
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Term
| What is the drug treatment for Neurogenic Diabetes Insipidus? |
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Definition
| Desmopressin (DDAVP) a.k.a Vasopressin - Synthetic ADH. Client Teaching: Careful adjustment of water intake with treatment to avoid water intoxication and dilutional hyponatremia. |
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Term
| What is the drug treatment for Nephrogenic Diabetes Insipidus? |
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Definition
| Hydrochlorothiazide (HCTZ) - Usually take with K+ sparing diuretics. Why HCTZ therapy? - Paradoxical effect in DI - Decreases polyuria, Increases osmolality. |
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Term
| What is the drug treatment for Addison's Disease? |
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Definition
| Cortisol - PO hydrocortisone (Cortef). Aldosterone - PO mineralocorticoid (Fludrocortisone acetate (Florinef), usually advised to increase salt intake. |
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Term
| What is the drug treatment for Cushing Syndrome? |
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Definition
| Ketoconazole (Nizoral) - Inhibits glucocorticoid synthesis. Mitotane (Lysodren) - Suppresses cortisol production. Aminoglutethimide (Cytadren) - Drug of choice during pregnancy. |
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Term
| What is the drug treatment for Pheochromocytoma? |
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Definition
| Phenoxybenzamine - Long acting alpha-adrenergic receptor blocking agent/blocks noradrenalin. Beta-Blocker - control adrenaline. |
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Term
| What is the drug treatment for RA? |
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Definition
| Methotrexate (Rheumatrex) - Immunosupressive. Hydroxychloroquine (Plaquenil) - slow progression of RA when used with another DMARD, used alone or in combo with Methotrexate for early/mild RA. |
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Term
| What is the drug treatment for Gout and Gouty Arthritis? |
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Definition
| Allopurinol (Zyloprim) - Inhibits production of uric acid, Prophylaxis. If gastric irritation take with food or milk. Colchicine (Colcrys) - Specific to Gout, Inhibits leukocyte infiltration (disrupts cell division). teach to avoid Alcohol, Grapefruit, and B12 Vitamin. |
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Term
| What is the drug treatment for Osteoporosis? |
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Definition
| Alendronate (Fosamax) - A biphosphate which is 1st line treatment for osteoporosis - Reduces fractures by 50%. Do not lie down for 1/2 hour after taking, No food, drink, calcium or vitamins for 2 hours (b/c only 1% bioavailability). Raloxifene (Evista) - Mimics estrogen by increasing bone density, reduces spinal fractures by 50%. Calcitonin-Salmon (Miacalcin) - Inhibits bone removal by osteoclasts |
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Term
| What do small doses of antacids do? |
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Definition
| Increase secretion of mucous, PGE, HCO3 |
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Term
| What do large doses of antacids do? |
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Definition
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Term
| What are the indications of use for antacids? |
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Definition
PUD (Healing)
GERD (Symptoms)
Stress Ulcers (Prophylaxis) |
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Term
| What is the GI drug that alters when exposed to gastric acid? It is a sticky thick gel that forms a protective barrier. Indications of use are for duodenal ulcers and gastric ulcers. |
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Definition
| What is Sucralfate (Carafate)? |
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Term
| What GI drug is the one that is a Histamine type 2 receptor antagonist. It blocks H2 receptor and reduces gastric acid secretion. It's indications are with GERD it relieves symptoms and with PUD it promotes healing and PUD prophylaxis. It's interactions with other drugs are that it Inhibits CYP 450 enzymes. |
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Definition
| What is Cimetidine (Tagamet)? |
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Term
| What is the proton pump inhibitor that binds to the proton pump and blocks final production step of HCL. It's indication for use is short term treatment of PUD and GERD. |
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Definition
| What is Omeprazole (Prilosec)? |
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Term
| What is the GI drug that is a Prokinetic Agent? It's MOA is that it increases upper GI motility and suppresses emesis. It's indications are GERD and Chemo induced N/V. |
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Definition
| What is Metoclopramide (Reglan)? |
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Term
| What are the drugs for the Inflammatory bowel diseases? |
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Definition
Sulfasalazine (Azulfidine)
Budesonide (Entocort EC)
Infliximab (Remicade) |
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Term
| What does Sulfasalazine (Azulfidine) do? and what is it's indication for use? and Nursing Implications? |
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Definition
| It reduces inflammation and is indicated for Inflammatory bowel disease or RA. It's nursing implications are that you have to monitor for CBC and there is a delayed effect 3-21 days. |
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Term
| What is the drug use for Budesonide (Entocort EC)? |
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Definition
| It is used for symptom relief for ulcerative colitis and Crohn disease. Not for long term therapy. |
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Term
| What does Infliximab (Remicade) do and what is it's indication and side effects? |
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Definition
| It inhibits TNF-alpha (inflammatory cytokine) and is indications are for moderate to severe chrons disease or ulcerative colitis. It's adverse effects are Infection and Infusion reactions and lymphoma. |
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Term
| What are the chemical bonds in from strongest to weakest in an aqueous environment? covalent, hydrogen, ionic bond, hydrophobic? |
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Definition
1) Covalent: sharing of electrons (Co2) sharing is not always equal. Strong Bond
2) Iconic bond: cation and anion bonded together (Na+, Cl-) Strong but in H20 weak
3) Hydrogen: bonding btwn H+ and O- or N- (H20)
4) Hydrophobic: nonpolar, weak |
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