Direct acting cholinergic agonist

Muscarinic

Promotes Bladder Voiding

Don't use with obstruction

Direct Acting Cholenergic Agonist

Muscarinic

Pupil constriction, decrease occular pressure with glaucoma

Idirect Acting Cholinergic Agonist

AChE inhibitor

Counter anticholinergic toxicity

Not quaternary- crosses BBB

Indirect Acting Cholinergic Agonist

Stimulates visceral SM

Cholinergic antagonist

Decreases Salivary and airway secretions

Relieves symptoms of AChE poisoning

Cholinergic antagonist

Similar to atropine

Cholinergic Antagonist

Similar to atropine, but:

quaternary

little CNS effects

Prevents vagal-mediated bradycardia

Cholinergic Antagonist

Topically induce mydriasis and cycloplegia 

Cholinergic Antagonist

Bronchodilation

Decrease Airway Secretion

Quaternary

Cholinergic Antagonist

Promote Urine Retention

Decreased detrusor contraction

Increased trigone Sphincter contraction

Depolarizing NMJ Blocker (Non-Competitive)

○     Mimics ACh at NMJ

■     Resistant to AChE

■     Not pharmacologically reversible

○     Rapid onset and ultra-short acting

○     Can cause hyperkalemia

Non-Depolarizing NMJ Blockers (Competitive)

(short lasting)

Promotes histamine release

t^1/2 not increased with renal disease

Non-Depolarizing NMJ Blockers (competitive)

(Intermediate)

half-life increased with hypothermia and acidosis

Half-life not increased with renal disease

`Non-Depolarizing NMJ Blockers (Competitive)

(long lasting)

Blocks muscarinic receptors (tachycardia)

Half-life increased with renal disease

Direct acting Adrenergic Agonist

Alpha nad Beta agonist

Beta-1:Increased CO

Beta-2: Bronchodilation

Direct acting adrenergic agonist

Intense vasoconstriction and increased BP

Vagal reflex slows HR

Preferred over Epi to maintain BP during shock associated with vasodilation

No B2 effect=no broncho dilation

Direct Acting Adrenergic Agonist

D1 dopamine receptors

Increased renal BF and Na excretion

Positive ionotropic effect

Low doses IV for CHF with compromised renal function

Low dose during shock

Direct Acting Adrenergic Agonist

B1 Agonist

Positive inotropic effect

low dose IV for CHF with Comp. renal Fnctn

Low dose during shock

Selective B2 Adrenergic Agonist (Bronchodilator)

For Bronchspasm

Selective B2 Adrenergic Agonist (Vasoconstrictor)

For Recurrent airway obstruction - "heaves"

Selective A1 Adrenergic Agonist (Vasoconstrictors)

Decongestant

Vasopressor (Raise BP)

Selective A2 Adrenergic Agonist (sedation)

Adjunct for sedation, anesthesia, and analgesia

Decreases sympatheic outflow via presynaptic inhibition

Non-Selective Alpha Antagonist

Reduces urethral Sphincter tone

Non-competitive- irreversible

Non-selective Alpha Antagonist

Reduces urethral Sphincter tone

Compertive-reversible

Selective Alpha 1 Adrenergic Antagonist

(Decrease BP)

Arterial and venous vasodilation

Selective alpha 2 Adrenergic Antagonist (Reverse Sedation)

Used to reverse sedative and analgesic effects of medetomidine

Increases Sympathetic activity

Nonselective Beta Adrenergic antagonist

antiarrhythmic from decreased sympathetic activity

Decreased CO

Bronchoconstriction due to B2 receptors (bad)

Nonselective Beta Adrenergic antagonist

Ocular use to decrease aqueous humor production during glaucoma

Selective Beta 1 Adrenergic Antagonist

Decreases HR

Reduced cardiac oxygen demand

Antiarrhythmics

 Na Channel Blocker

Class Ia

Moderate conduction slowing

Prolongs refractory period

Prolongs AP

Antiarrhythmics

Na Channel Blocker

Class IB

Little Conduction Slowing

Shortens refractory period

Prolongs AP

Can be used for ventricular tachycardia

Antiarrhythmic

Na Channel Blocker Class IC

Profound conduction slowing

Little Change in refractory period

Antiarrhythmic

Beta Adrenergic Antagonist Class II

Beta 1

Decreases HR

Reduced Cardiac oxygen demand

Antiarrhythmic

Beta Adrenergic Antagonist Class II

(Beta 1 and 2)

Antiarrhythmic fom decreased sympathetic stimulation

Decreased CO

Bronchoconstriction due to B2 receptors (bad)

Antiarrhytmic

Action Potential Prolonging: Class III

Block K channels, do not effect Na Channels

Calcium channel blocker (Class IV)

Cardiac and vascular 

decrease ventricular response to atrial fibrilation

Inhibits Ca channels in cardiac myocytes/nodal cells

slows AV nodal conduction

Verapamil

Calcium Channel Blockers: Class IV

Cardiac and vascular

Decrease ventricular response to atrial fibrilation

Inhibits calcium channels in cardiac myocytes/nodal cells

slows AV nodal conduction

Can decrease cardiac contractility 

Modulator of cardiac contraction

Beta 1, Alpha 1

Increase renal blood flow and Na excretion

Positive inotropic effect

Increase CO with less vasoconstriction (less alpha 1)

Phosphodiesterase Inhibitor

Increased cAMP

Increased Contraction

Digoxin

Increased cardiac myocyte intracellular Ca

Inhibits Na/K ATPase

Decreases Ca efflux indirectly

Calcium sensitizer

Enhances contractile process directly

For CHF

Not associated with arrythmias

Vasodilator

ACE inhibitor

Prevents conversion of Ang I to Ang II

Vasodilator 

(AT1R antagonist)

Blocks hypertensive effects of Ang II

Vasodilator

Selective alpha 1 adrenergic antagonist

may cause "reflex tachycardia" (increased CO)

Vasodilator 

Calcium Channel Antagonist

vascular

Decrease total peripheral resistance

May cause reflex tachycardia

Vasodilator

Opens K channel in arterial SM

Decreased opening of Ca channels

Decreased TPR and BP

Venous dilator

Decreased preload

nitrovasodilator

arterial and venous dilation

decreased afterload and preload

Big drop in BP

Phosphodiesterase Inhibitor

vasodilation 

Pulmonary hypertension

Osmotic diuretic

Small molecular weight used for

Oliguric renal failure 

Cerebral edema 

Acute glaucoma

Carbonic Anhydrase Inhibitor

Weak diuretic

May cause hypokalemia 

Used for metabolic alkalosis, glaucoma

Loop diuretic

May cause hypokalemia

Used to treat Oliguric renal failure,

CHF

Acute Pulmonary hypertension

EIPH

Thiazide diuretics

Not as effective as loop diuretics

Used for edema in cattle 

Calcium containing uroliths

K Sparing Diuretic

Competitive aldosterone antagonist

Delayed onset and prolonged effect

Mild diuresis 

Most often in combo with loop diuretic

K sparing Diuretic

Principal cell sodium channel blocker

Immediate but mild diuretic effect

most often in combo with loop diuretics 

K sparing diuretic 

Principal cell sodium channel blocker