Term
mult sclerosis is a _ disorder
what does it attack |
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Definition
autoimmune
mylin sheaths in CNS |
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Term
| * no single defining symtpo for mult scelrosis |
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Definition
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Term
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Definition
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Term
mult is more in women or men
where at in the world |
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Definition
women
N. Europe and higher latitude above 37th parellel |
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Term
| *evidence for both env and genic factors, dont know eact % |
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Definition
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Term
| 3 time periods of age env plays role |
|
Definition
perinatal
adolescence
age of onset |
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Term
| how does perinatal correlate with MS? |
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Definition
| doubling of it btwn twins |
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Term
adolesnce with MS?
what is the cut off age |
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Definition
correlates where they live.
15 years old |
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Term
| MS higher w/ ppl born in what month and lower in what month |
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Definition
MAY
novemebr
(these are revesed in southern hemisphere) |
|
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Term
| are Mendelein genetics involved in MS? |
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Definition
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Term
| what genes are really invovled in MS-2 |
|
Definition
HLA
IL7R (t and b cell survival) |
|
|
Term
| other risk factros of Ms not so major-3 |
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Definition
IRF8- trnascription
TYK- kinases
CD6- cell adhesion |
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Term
| why do the neuro phenoytpes vary per pt |
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Definition
| bc where immune attacks is never the same per pt and it can recede and reoccur |
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Term
| why is MS dissmeinated in time and space |
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Definition
| it can recede an then reappear in newp place |
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Term
initila symptoms:
_ :24%
-:11%
_: 2% |
|
Definition
parethesias
ataxia
dementia |
|
|
Term
| what does replasing/remitting MS mean |
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Definition
| sudden onset for wks then dissapear for months |
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Term
| what does 2nd progression MS mean |
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Definition
| was remession, but now steady deterioration |
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Term
| what does primary porgressive MS mean |
|
Definition
| disease insdiious without intial attack |
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Term
| progressive/relapsing MA measn |
|
Definition
| mix of primaru and secondary as begin insdiiously but can relapse |
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Term
| what ist he biggest sx in later MS stage |
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Definition
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Term
|
Definition
mononuclear cell infiltrate brain (T, macrophage, B)
dymelination
scarring |
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|
Term
MRI is sued to show lesion in white, can also see BB breakdown*
gray matter cna only been seen psot mortem |
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Definition
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|
Term
| MRI shows more lesion than symptoms present* |
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Definition
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Term
| CSF shows BBB breakdown how-2 |
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Definition
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Term
| during MS myline is destroyed and leave naked axon* |
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Definition
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Term
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Definition
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Term
mylin is 70% lipdo, but what play role in creating and stabilizing it?
what are the 4 mian ones
* T celss in MS are reactive to these |
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Definition
protein
PLP (proteolip), MAG (mylin-assoc), MOG (mylin-olig), MBP (myline basic)` |
|
|
Term
| for full expresison of MS what is needed |
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Definition
| antibodies to mylin proteins on surface of mylin and B cells |
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Term
| *immunz mice of MBPproduced expirimentl allergic enceph= supportimmune destruction hypothesis |
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Definition
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|
Term
* no mylin = no action potential
also expose dormant K channels |
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Definition
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Term
| why is exposing dormant K channels bad in MS? |
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Definition
| hyporpolarization lead to codnuction block and fail of action potentials |
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Term
the infalmm process on mylin recruits-2
what do they produce |
|
Definition
microglia
astorcytes
gliosis/scarring |
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|
Term
| *normally oligodendracytes precursors surround the affected lesion which can remylinate axons, howver in MS the lesion inhibit this somehow |
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Definition
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