Term
| acute tx of ischemic stroke-2 (include time limit) |
|
Definition
tPA in 3 hrs
aspirin in 48 hrs |
|
|
Term
| what is the rule about aspirin and t PA |
|
Definition
| dont give aspirin w/i 24 hrs of t PA |
|
|
Term
|
Definition
| fibrinolysis due to serine protease(plasminogen to plasmin) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| bind to fibrin, cleaves plasminogen to activate plasmin |
|
|
Term
|
Definition
| 10 fold lwoer for single chain form |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| which t pa is suppse to be resistnat to PAI-1 inactivation |
|
Definition
|
|
Term
|
Definition
|
|
Term
| whihc t pa has longer half life |
|
Definition
|
|
Term
|
Definition
|
|
Term
| drug interactions w/ t PAs-4 |
|
Definition
| heparin, Vit K anatg, anti thrombitic, anti platelet |
|
|
Term
Aspirin ireereviersibly binds-
what does this do? |
|
Definition
COX 1
stops synth of thromboxane A2 (vasoconstrict |
|
|
Term
| hat does aspirin not protect against |
|
Definition
|
|
Term
| secondary prevention of stroke-2 |
|
Definition
|
|
Term
| MOA of antiplatelets with stroek prevntion |
|
Definition
| interefere with activation of platelet binding with fibrin |
|
|
Term
| 1st line thrapy for 2d prevention of stroek with anti platelets |
|
Definition
|
|
Term
| what are the thienopyridine (ADP blockers)-2 |
|
Definition
|
|
Term
| what are the glycoprotein 2b/3a inhiors-3 |
|
Definition
abciximad
eptifibatide
tirofiban |
|
|
Term
| what are the antiplatelts classes besides aspirin |
|
Definition
thiopyridines
glycoprotein 2b/3a inhbi |
|
|
Term
| ADP recpt blockers/thienopyrdines prevent stroke how |
|
Definition
| ADP is an intitator of platelet aggregation |
|
|
Term
| for ADP recptor what is the rule about blocking one of the recptors only |
|
Definition
| this is stop the platelet activaiotn bc need both recpotrs! |
|
|
Term
| ticlopidine inhibits which aDP recpot |
|
Definition
|
|
Term
| the serious ADE with ticlopidine is |
|
Definition
|
|
Term
| which ADP recpt drug isthe prodrug |
|
Definition
| ticlopidine and clopidogrel! |
|
|
Term
| how does GP 2b/3a cause stroke |
|
Definition
| activated recpt bind adhesive molecules like fibrinogen to aggegate platelets |
|
|
Term
|
Definition
|
|
Term
| what is the name for ER dipyridamole + aspirin |
|
Definition
|
|
Term
| what coag factors does warfarin work on-3 |
|
Definition
|
|
Term
| what factor deos dabigitran work on? |
|
Definition
|
|
Term
| whcih anticoag has good oral bioavial (which is why its normally oral) |
|
Definition
|
|
Term
whihc anticoag is a direct thromibin inhibitor
why? |
|
Definition
dabigitran
inhibits both bound AND free thrombin |
|
|
Term
| what factor does rivaroxiban inhibit |
|
Definition
|
|
Term
| BP lowering agents for ppl wo have had stroke- |
|
Definition
|
|
Term
| which ARB is specifical approved for reducin stroke in HTN pts |
|
Definition
|
|
Term
|
Definition
| inhibit endog cholesterol-> less plt aggregation |
|
|
Term
| statins decrease stroke risk by-% |
|
Definition
|
|
Term
|
Definition
|
|
Term
| prevention of hemorrhagic stroke? |
|
Definition
|
|
Term
| acute tx for hemorrhagic stroke-2 |
|
Definition
hemostatic agents- factor 7 (clot factor)
Ca channel blocker- nimodipine |
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|
