Term
| Systemic Lupus Erythematosusm (SLE) |
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Definition
| "the great immitator" 4 of 11 symptoms must be present for diagnosis |
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Term
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Definition
| progressive inflammation, joint destruction, loss of function. DIP and PIP. Swan neck deformity. Boutinnier deformity. Z-thumb deformity. Ulnar deviation. doughy swelling and warmth. worse in the morning. |
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Term
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Definition
| antibodies against Fc portion of IgG |
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Term
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Definition
| autoimmune destruction of thyroid causing hypothyroidism |
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Term
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Definition
| autoimmune destruction of islaet cells causing decreased insulin production. Reactive hyperglycemia. Low C-peptide levels. |
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Term
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Definition
| autoimmune destruction of acetylcholine receptors at the post-synaptic cleft which blocks muscle contraction |
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Term
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Definition
| IgE mediated. Classical Allergy. |
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Term
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Definition
| enter body thru inhalation. causes edema of nasal mucosa and swelling of upper respiratory tract and sinuses |
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Term
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Definition
| enter body thru inhalation. Causes bronchial constriction, increased mucous production, and airway inflammation. |
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Term
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Definition
| Enters thru IV (direct or indirect through oral absorption). systemic. shock-like symptoms. |
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Term
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Definition
| Entry is oral. Causes vomitting, diarrhea, hives, etc. |
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Term
| Treatments for Type I Hypersensitivity |
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Definition
| Anti-IgE. Anti-histamine. Anti-inflammatories. Epinephrine (inhibits degranulation of mast cells). Allergy shots (desensitization). |
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Term
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Definition
| common, more virulent form of HIV |
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Term
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Definition
| strain of HIV endemic to Africa and not as virulent |
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Term
| Phase I of AIDS progression |
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Definition
| flu-like symptoms. virus is multiplying. |
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Term
| Phase II in AIDS progression |
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Definition
| Opportunisitic infections. Th cells affected. |
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Term
| Phase III in AIDS progression |
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Definition
| Th cells < 200/mL. opportunisitc infection or cancer. officially called AIDS. |
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Term
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Definition
| IgG or IgM mediated. Cytotoxic. |
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Term
| Hemolytic disease of the New Born |
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Definition
| Rh (-) mom makes antibodies against her baby's Rh (+) antigens. When mom has a second Rh (+) baby, mom's hummoral system attacks the baby causing erythroblastosis fetalis. |
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Term
| Autoimmune Hemolytic Anemia |
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Definition
| body attacks its own RBCs |
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Term
| Autoimmune Thrombocytopenia Purpura |
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Definition
| Body attacks its own platelets |
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Term
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Definition
| Auto-antibodies against desmosomes in skin, causes blisters on skin and mucous membranes. |
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Term
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Definition
| Auto-antibodies against type IV collagen in the basement membrane of kidney. Causes glomerular nephritis and lung hemorrhage. |
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Term
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Definition
| occurs after strep infection. Strep M protein mimics myosin. Affects heart and joints. |
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Term
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Definition
| attacks presynaptic membrane at neuromuscular junction |
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Term
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Definition
| attacks Thyroid, causes hyperthyroidism |
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Term
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Definition
| attacks stomach cells, reduces production of intrinsic factor, which is a protein that helps the body absorb B12 |
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Term
| Type III hypersensitivity |
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Definition
| IgG-mediated. Immune complexes deposit causing tissue damage and thrombosis. Neutrophils mediate most of the damage. |
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Term
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Definition
| localized immune complex deposition. Edema |
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Term
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Definition
| systemic immune complex deposition. fever. lymphadenopathy. splenomegaly. etc. |
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Term
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Definition
| CMI-mediated. Delayed Type. |
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Term
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Definition
| small molecule that can only ellicit an immune response when conjugated to a larger protein. these small molecules conjugate to body proteins, forming immunogenic substances |
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Term
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Definition
| sensitivity to gluten. damages small intestine and interferes with absorption of nutrients from food. |
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Term
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Definition
| contact dermatitis. small molecule attaches to protein in skin and sensitizies Th1 cells. Next time this hapten is encountered, Th1 cells mount a secondary response and macrophage infiltration which causes inflammation |
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Term
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Definition
| from one area in a person to another area in the same person |
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Term
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Definition
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Term
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Definition
| between two different people, not twins |
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Term
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Definition
| between different species |
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Term
| Direct Pathway of Rejection |
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Definition
| Foreign MHC presents its own antigen which is foreign to the recipient, and this activates the recipient's T cells. The cause of Acute Rejection. |
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Term
| Indirect Pathway of Rejection |
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Definition
| Recipient immune cells phagocytose cells from graft and present foreign MHC molecules to their T cells. This is the cause of Chronic Rejection. |
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Term
| Autologous Stem Cell Transplant |
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Definition
| donor is self or identical twin. take stem cells from the patient, irradiate the patient, give them back their stem cells. the cells are not rejected. |
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Term
| Allogenic Stem Cell Transplant |
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Definition
| donor is another person. they will be rejected unless the host immune system is repressed and T cells are eliminated from the donor. |
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Term
| First set allograft rejection |
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Definition
| the first time a donor gives cells to a recipient, they are rejected within 2 weeks, and now the host's T cells are primed against this particular donor |
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Term
| Second set allograft rejection |
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Definition
| cells from a donor are given a second time, and now a secondary immune response is mounted against the donated cells because memory T cells exist against it. it is rejected within 1 week. |
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Term
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Definition
| transplant is destroyed by pre-existing antibodies, a secondary response. This is a second set rejection. No CMI response. |
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Term
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Definition
| Donor APCs migrate to host lymph nodes and present their antigens to the host's T cells, which starts an immune response. This is direct pathway of rejection. Most Common. |
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Term
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Definition
| months to years after transplant, indirect pathway of rejection. |
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Term
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Definition
| Donor T cells attack the host's antigens. Avoid by removing T cells from graft before transplanting. |
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Term
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Definition
| drop of donor RBC mixed with a drop of patient's plasma. If agglutination occurs, they are not compatible. |
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Term
| Acute Transfusion Reaction |
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Definition
| Recipient's IgM mounts a response against the donor's A or B antigen, causing rapid hemolysis of donor RBCs. Causes Renal Failure, anaphylaxis, and cardiovascular collapse. |
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Term
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Definition
| serum is pink because of excess Hb in blood plasma |
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Term
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Definition
| urin is dark because of blood |
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Term
| Transfusion Related Acute Lung Injury |
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Definition
| immune complexes enter pulmonary bed and release vasoactie amines which causes vasodialation, plasma leakage, and pulmonary edema |
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Term
| Severe Combined Immune Deficiency |
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Definition
| deffective cell mediated and humoral immunity |
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Term
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Definition
| decreased T cells, normal or decreased B cells but low IgG |
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Term
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Definition
| Both B and T cells present but not functional due to a cytoskeletal defect |
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Term
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Definition
| decreased B and T cells due to decreased purine degradation enzymes |
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Term
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Definition
| B and T cells not functional due to increased lymphocyte sensitivity to oxidative DNA damage |
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Term
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Definition
| T cells nonfunctional, B cells absent, due to mutation in RAG |
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Term
| X-linked agammaglobulinemia |
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Definition
| decreased B cells and Igs. |
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Term
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Definition
| recurrent respiratory or GI infections |
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Term
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Definition
| T cell deficiency, thymic hypoplasia |
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Term
| Chronic Granulomatous Disease |
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Definition
| phagocytes can't make ROS |
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Term
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Definition
| phagocytes can't make lysosomes |
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