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| Complement deposits on host cells causing them to be a target for destruction |
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| Immune response that harms the host |
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| Immediate type hypersensitivity |
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Definition
| Types I, II & III; symptoms develop within minutes to hours |
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| Delayed type hypersensitivity |
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Definition
| Type IV; manifests within 24-48 hours |
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Definition
| Trigger the formation of IgE |
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| Inherited tendency to continually produce IgE in response to naturally occurring allergens |
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| The immune system doesn't discriminate self from non-self |
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| Extractable nuclear antigens |
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| Connective tissue diseases |
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Definition
| SLE, SS, Scleroderma, RA, MCTD & polymyositis/dermatomyositis |
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| IgM directed against the Fc portion of IgG |
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Definition
| Transplanted tissues or organs |
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| Donor tissue or organ is from the host for the host |
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| Transplant between identical twins |
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| Transplant between genetically different individuals of the same species |
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| Transfer of tissue or organ from one species to another |
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| New uncontrolled growth of cells derived from one's own tissues |
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| Abnormal tissue resulting from uncontrolled growth |
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| Tumor usually confined to a single site |
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| Cancer that originates from epithelial cells |
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| Cancer that originates from connective tissues |
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Definition
| Malignant hematopoietic cells (single cells) |
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Definition
| Malignant hematopoietic cells (tumor masses) |
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Definition
| Spread of a disease process from one part of the body to another |
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Definition
| Cancer-producing substances |
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Definition
| Ongoing removal of abnormal cells by the immune system |
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Definition
| Monoclonal antibodies + toxin |
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Definition
| Genes capable of producing neoplastic transformation |
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Definition
| Genes that promote normal cell proliferation |
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Definition
| Genes that normally inhibit growth of tumors |
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| In the immunofluorescent test for ANA, what specific antigenic substrate is used? |
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With what condition is the rash shown commonly associated:
[image] |
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Definition
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Term
Identify the ANA pattern shown:
[image] |
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Definition
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| Other than homogeneous, what type of ANA pattern is strongly suspicious for Lupus? |
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Definition
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Term
| Which combination of specific ABYs are most helpful in the diagnosis of SLE? |
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Definition
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| What type of hypersensitivity is responsible for most of the tissue damage associated with SLE? |
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Definition
| Type III Hypersensitivity |
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Term
What specific antibody is demonstrated in the image below?
[image] |
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Definition
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Term
What is the substrate used in the image below?
[image] |
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Definition
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Term
| What specific organelle is reacting to the patient's ANA? |
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Definition
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Term
Identify the ANA pattern shown:
[image] |
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Definition
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Term
| If the physician suspects Sjogren's syndrome, what specific antibody test(s) should be performed? |
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Definition
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Term
| If the physician suspects diffuse scleroderma, what specific antibody test(s) should be performed? |
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Definition
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Term
Identify the ANA pattern shown:
[image] |
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Definition
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To what condition is this ANA pattern strongly linked?
[image] |
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Definition
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Identify the ANA pattern below:
[image]
[image] |
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Definition
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| What ANA pattern is associated with drug-induced lupus? |
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| John (age11) has been plagued with ear infections, recurrent sore throats and tonsilitis since the age of 3. At age 10 he began to have summer hay fever and asthma. He recently suffered several episodes of gastroenteritis.Which immunoglobulin is most likely deficient? |
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Ms. T (age 24) complained of extreme muscle tiredness which became worse with repetitive movements. When she began having episodes of double vision, she went to see her doctor who noted that one of her eyelids drooped. Ms. T also had difficulty in opening her hands after amking a tight fist. After a battery of tests, she was diagnosed with Myasthenia gravis.
What is the target of Ms. T's autoantibodies? |
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Definition
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Term
Ms. T (age 24) complained of extreme muscle tiredness which became worse with repetitive movements. When she began having episodes of double vision, she went to see her doctor who noted that one of her eyelids drooped. Ms. T also had difficulty in opening her hands after amking a tight fist. After a battery of tests, she was diagnosed with Myasthenia gravis.
What hypersensitivity type is causing the damage in Ms. T? |
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Definition
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Term
Ms. T (age 24) complained of extreme muscle tiredness which became worse with repetitive movements. When she began having episodes of double vision, she went to see her doctor who noted that one of her eyelids drooped. Ms. T also had difficulty in opening her hands after amking a tight fist. After a battery of tests, she was diagnosed with Myasthenia gravis.
Considering her age, what HLA antigens are associated with Ms. T's Disease? |
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Definition
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Term
Ms. L was given a bracelet and earring set by her boyfriend and had worn it on several occasions. However, she began noticing a rash on her ears and neck. Her doctor performed a patch skin test, and Ms. L showed eczematous reactions to nickel and rubber. Ms. L was advised to stop wearing the jewelry and to avoid contact with rubber gloves.
What type of hypersensitivity does this patient have? |
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Definition
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Term
Ms. L was given a bracelet and earring set by her boyfriend and had worn it on several occasions. However, she began noticing a rash on her ears and neck. Her doctor performed a patch skin test, and Ms. L showed eczematous reactions to nickel and rubber. Ms. L was advised to stop wearing the jewelry and to avoid contact with rubber gloves.
What is the mechanism of the "antigen" in Ms. L's jewelry? |
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Definition
| The metal (in the jewelry) functions as a hapten that binds to protein on the skin |
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Term
Ms. L was given a bracelet and earring set by her boyfriend and had worn it on several occasions. However, she began noticing a rash on her ears and neck. Her doctor performed a patch skin test, and Ms. L showed eczematous reactions to nickel and rubber. Ms. L was advised to stop wearing the jewelry and to avoid contact with rubber gloves.
What other examples of hypersensitivity falls into the same class as Ms. L's reaction? |
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Definition
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Term
Ms. L was given a bracelet and earring set by her boyfriend and had worn it on several occasions. However, she began noticing a rash on her ears and neck. Her doctor performed a patch skin test, and Ms. L showed eczematous reactions to nickel and rubber. Ms. L was advised to stop wearing the jewelry and to avoid contact with rubber gloves.
What is the best course of treatment for Ms. L's type of hypersensitivity? |
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Definition
| Avoid contact with the antigen |
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