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Physiology
Exam 3
211
Physiology
Professional
10/07/2012

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Cards

Term
Which division of the PNS innervates smooth muscle?
Definition
Autonomic Nervous System
Term
Which division of the PNS innervates organs? Glands?
Definition
Autonomic Nervous System

Autonomic Nervous System
Term
What is the key feature of an autonomic nerve pathway?
Definition
Two-neuron chain
Term
Where does the preganglionic neuron originate?
Definition
CNS
Term
How could one describe the preganglionic neuron pathway?
Definition
preganglionic neuron originates in the CNS and synapses with the cell body of the postganglionic fiber outside the CNS
Term
Which type of neuron sends axons that end on the effector organ?
Definition
Postganglionic neuron
Term
The CNS sends a signal down the _____________________. The ______________ then attaches to the ______________. A signal then passes down the ________________ which then releases a _______________ to the effector organ
Definition
Preganglionic fiber

preganglionic neurotransmitter

autonomic ganglion

postganglionic fiber

postganglionic neurotransmitter
Term
What division of the autonomic nervous system is referred to as fight or flight?
Definition
Sympathetic division
Term
What is the purpose of the sympathetic division of the autonomic nervous system?
Definition
To prepare body for strenuous physical activity.
Term
Which division of the autonomic nervous system dominates in emergency or stressful situations?
Definition
Sympathetic division
Term
What division of the autonomic nervous system plays a major role in digestion?
Definition
Parasympathetic division
Term
Where do the preganglionic nerve fibers of the sympathetic division originate?
Definition
Thoracic and lumbar regions of the spinal cord
Term
What do the sympathetic preganglionic nerve fibers synapse with and where? (2 names for this location)
Definition
post-ganglionic cells in the sympathetic ganglion chain or the sympathetic trunk
Term
Where do sympathetic postganglionic fibers originate and where to the end/
Definition
Originate in the ganglion chain and end on the effector organs.
Term
Where do the parasympathetic preganglionic fibers arise from?
Definition
Cranial and sacral areas of the CNS
Term
What and where do the parasympathetic preganglionic fibers synapse?
Definition
synapse on postganglionic cells found in the terminal ganglia
Term
What is the relative location of terminal ganglia?
Definition
near effector organs
Term
What is wrong with this statement, if anything:

Terminal ganglia lie in or near the effector organ.
Definition
Everything is correct with this statement
Term
What is the difference between postganglionic cells of the parasympathetic system and the sympathetic system?
Definition
Sympathetic system contains long postganglionic fibers while the parasympthetic system contains very short postganglionic fibers
Term
True or False:

B1 and B2 receptors are found in the sympathetic division of the autonomic nervous system.
Definition
True
Term
True or False:

Muscarnic receptors are found in the sympathetic division of the autonomic nervous system.
Definition
False, found in the parasympathetic division
Term
Why is this statement false:

Preganglionic fibers and postganglionic fibers of the parasympathetic division are the only fibers which release ACh
Definition
ALL preganglionic fibers and parasympathetic postganglionic fibers release ACh
Term
What neurotransmitter is released from sympathetic postganglionic fibers?
Definition
Norepinephrine (NE)
Term
What determines if a cell is cholinergic or adrenergic?
Definition
Cholinergic release ACh

Adrenergic release NE
Term
True or False:

Most organs of the body are controlled by both divisions of the autonomic nervous system.
Definition
True
Term
True or False:

Most sweat glands are innervated only by parasympathetic nerves.
Definition
False only by "sympathetic nerves"
Term
What type of nerve fibers innervate most arterioles and veins?
Definition
sympathetic nerve fibers
Term
How do salivary glands pose an exception to the dual innervation rule?
Definition
Although they are stimulated by both divisions, each division stimulates a different form of saliva
Term
How does sympathetic activity affect the force of contraction of the heart?
Definition
Increases
Term
True or False:

Sympathetic stimulation causes vasodilation of the blood vessels.
Definition
False, it would vasoconstrict
Term
What affect does the parasympathetic division play on the lungs? (2)
Definition
Constricts bronchioles and stimulates mucus secretion
Term
What effect would the contraction of digestive sphincters play during digestion?
Definition
it would prevent forward movement of contents
Term
What effect does the sympathetic division play with the urinary bladder? What about the parasympathetic division?
Definition
Sympathetic division relaxes the bladder while the parasympathetic division contracts to empty the bladder
Term
True or False:

The parasympathetic division plays a major role with adipose cells and the liver.
Definition
False, it play no role
Term
If you are in fight or flight, would you rather adjust your eyes for far vision or close vision?
Definition
Far vision
Term
What role does the parasympatheic system play with the adrenal medulla? Why?
Definition
None because the adrenal medulla secretes E and NE which are sympathetic hormones
Term
What is the ratio of epinephrine to norepinephrine secreted by the adrenal medulla?
Definition
80% E to 20% NE
Term
What are the two cholinergic receptors?
Definition
Nicotinic and muscarinic
Term
What are the four adrenergic receptors?
Definition
A1 A2 B1 and B2
Term
How does an autonomic antagonist work?
Definition
The antagonist molecule binds to the receptor and blocks the neurotransmitter response
Term
What type of drug would you use to treat asthma?
Definition
B2 agonist
Term
What type of drug would be used to treat a fast heart rate?
Definition
B1 antagonist
Term
What type of drug would be used to treat overactive bladder?
Definition
Acetylcholine antagonist
Term
What brain structure is directly responsible for autonomic output?
Definition
Medulla
Term
What brain structure plays a role in integrating autonomic, somatic, and endocrine responses?
Definition
Hypothalamus
Term
What are autonomic reflexes integrated at?
Definition
Spinal Cord level
Term
Where to axons of motor neurons originate and where do they end?
Definition
Originate in the spinal cord or brain stem and end on skeletal muscle
Term
What neurotransmitter stimulates muscle contraction?
Definition
ACh
Term
What role do motor neurons play in the CNS having control over skeletal muscles?
Definition
They serve as the final common pathway by which the CNS exerts control over skeletal muscles
Term
Where does ACh bind to and where are these located?
Definition
ACh binds to special receptor channels on the motor end plate of a neuromuscular junction
Term
How is an end plate potential produced?
Definition
Ion movements depolarize the motor end plate causing EPP
Term
How is an action potential produced at the neuromuscular junction?
Definition
Local current flow between depolarized end plate and adjacent membrane triggers an action potential
Term
How do valves open and close? Why?
Definition
Passively becaus elf pressure differences
Term
What is another name for the right av valve?
Definition
Tricuspid
Term
What are the two other names for the left av valve?
Definition
Bicuspid or mitral valve
Term
Which type of valves prevent back flow during relaxation?
Definition
Semilunar
Term
What interconnects cardiac fibers?
Definition
Intercalated discs
Term
What two types of junctions do intercalated discs contain?
Definition
Desmosomes and gap junctions
Term
True or false,

The majority of cardiac cells are autorhythmic.
Definition
False only one percent are
Term
Which type of cardiac cells present pacemaker activity?
Definition
Autorhythmic
Term
Describe a pacemaker potential.
Definition
Slow depolarization in between action potentials
Term
What channels open during a pacemaker potential and which way do the ions flow.
Definition
Na and ca channels both flow in
Term
During a pacemaker action potential, which channels are open and which way do ions flow?
Definition
Ca channels open and flow in cell
Term
During. Pacemaker action potential, which channels are open and which way do the ions flow?
Definition
K channels open and flow out
Term
Describe the action potential of a contractile cardiac cell.
Definition
Sodium channels open and cause an immediate depolarization to maximum. Potassium channels now open and the ions exit quickly but the calcium channels are slowly flowing in causing a plateau. Eventually, the calcium channels close and the potassium channels remain open which causes an immediate hyperpolarization
Term
What is resting potential in cardiac contractile cells?
Definition
-90mV
Term
During the plateau phase of contractile action potential, what type of channels are being used?
Definition
Transient and leaky
Term
During the falling phase of contractile cell action potentials, what type of channels are being used?
Definition
Voltage gated
Term
What does the refractory period occur with cardiac action potentials?
Definition
During the Entire action potential phase and all but the tail end of the contractile phase
Term
Where do the cells that make up the bundle of his originate?
Definition
At the av node
Term
What are Purkinje fibers?
Definition
Terminal fibers that extend from the bundle of his and spread throughout ventricular myocardium
Term
True or false,

Atrial excitation and contraction must be completed before ventricular contraction can begin.
Definition
True
Term
What structure passes atrial conduction to the ventricles?
Definition
Av mode
Term
Why is there a pause In action potential at the av node?
Definition
To ensure ventricle can completely fill to potential before contraction
Term
How do electrical impulses travel through the myocardium?
Definition
Purkinje fibers
Term
How do electrical impulses travel down inter ventricular septum?
Definition
Bundle of his
Term
How do ventricular impulses travel if the are not the myocardium or interventricular septum?
Definition
Gap junctions
Term
What does the p wave stand for on an EKG?
Definition
Atrial depolarization
Term
Which part of an EKG is the av node delay?
Definition
Pr segment
Term
What event occur during the qrs complex on an EKG?
Definition
Ventricular depolarization and atrial repolarization simultaneously
Term
What occurs during the st segment on an EKG?
Definition
Ventricles are contracting and emptying
Term
What part of an EKG shows Ventricular repolarization?
Definition
T wave
Term
What is the tp segment on an EKG?
Definition
Time which ventricles are relaxing and refilling
Term
What is the longest phase of an EKG?
Definition
Tp segment
Term
What is the longest wave duration during an EKG?
Definition
T wave
Term
True or false,

The p wave takes longer to occur than a t wave.
Definition
False
Term
What brings about mechanical changes with cardiac cycle contraction?
Definition
Rhythmic changes in electrical activity
Term
True or false,

Systole refers to the contraction of the heart.
Definition
True
Term
During ventricular diastole, when significant event occurs?
Definition
Ventricles fill with blood
Term
What occurs during isovolumetric ventricular contraction?
Definition
All four valves are closed and pressure rises
Term
What force pushes blood during ventricular ejection?
Definition
Pressure
Term
What phaseof cardiac mechanics is characterized by pressure falling and returning to Ventricular diastole?
Definition
Ventricular repolarization
Term
Why is pressure low during ventricular diastole?
Definition
Semilunar valves are closed
Term
What percentage of blood flows from atria to ventricle passively?
Definition
Seventy percent
Term
Once seventy percent of blood flows from atria to ventricle passively, how does the rest of the blood flow into ventricle?
Definition
Sa node fires and Atria contracts To push the remaining 30 percent into ventricles
Term
What process pushes 30 percent of blood into the ventricles?
Definition
Atria systole
Term
What portion of an EKG could one observe atria systole?
Definition
P wave
Term
What portion of an EKG could you observe isovolumetric ventricular contraction?
Definition
Qrs complex
Term
When would you hear S1 on the EKG?
Definition
Whenn ventricular pressure rises and the av Valves close
Term
How do semilunar valve Open to end isovolumetric ventricular contraction?
Definition
Pressure rising past critical point which exceeds pulmonary trunk pressure And aortic pressure
Term
Where does blood flow during ventricular ejection?
Definition
Either pulmonary artery or the aorta
Term
What phase of cardiac mechanics would you hear S2?
Definition
Ventricular relaxation
Term
Which valves close when you hear s2?
Definition
Semilunar
Term
Which part of an EKG would you hear S2?
Definition
T wave
Term
What is the end diastolic volume? And what is the normal numeric volume?
Definition
Volume when ventricles are completely filled with blood.

135 mL
Term
What is the end systolic volume? And what is the numeric volume?
Definition
Volume left in the ventricle after ventricular ejection.

65 mL
Term
What is the stroke volume and how is it calculated?
Definition
Volume ejected from each ventricle per beat.

Calculated by subtracting esv from edv
Term
What are the differences between the two types of heart murmurs?
Definition
Stenoic murmurs occur when the valves do not completely open

Insufficient murmurs occur when the valves do not completely close
Term
What is cardiac output?
Definition
Volume of blood ejected by each ventricle, each minute
Term
Heart rate x stroke volume = ?
Definition
Cardiac output
Term
What two factors go into determining stroke volume? (not how it's calculated)
Definition
Venous return and sympathetic activity
Term
What extrinsic control has a factor in increasing stroke volume? How?
Definition
Increased sympathetic activity increases the strength of contraction which increases stroke volume.

Sympathetic activity by epinephrine
Term
What type of control does the frank starling law explain?
Definition
Intrinsic control
Term
Describe the frank starling law.
Definition
Increased venous return increases edv increases strength of contraction increases stroke volume
Term
True or false,

Cardiac output is most efficient at normal resting length.
Definition
False,

Optimal length for efficiency is at an increased length. Exactly opposite of skeletal muscle
Term
How does increased sympathetic activity affect end systolic volume?
Definition
It decreases it since it is increasing stroke volume
Term
If you increases edv as well as sympathetic activity, how does your esv relate to the esv value of just increasing sympathetic activity?
Definition
It is the same because the stroke volume is what gets affected not the esv
Term
What name refers to the type of organs that receive disproportionally high volumes of blood?
Definition
Reconditioning organs
Term
How is flow rate related to vascular resistance and pressure gradients?
Definition
Flow rate is directly proportional to pressure and inversely proportional to vascular resistance.
Term
What three factors affect vascular resistance?
Definition
Vessel radius, viscosity, Vessel length
Term
True or false,

Viscosity and vessel length play a major factor in vascular resistance.
Definition
False,

They don't play much of a role
Term
What is the ratio of resistance to vessel radius?
Definition
Resistance 1/ radius to the forth
Term
True or false,

The arteries control how much blood flows through each organ.
Definition
False,

The arterioles
Term
What is the function of capillaries?
Definition
To exchange materials between blood and the surrounding tissues
Term
What is an example of a rapid transit passenger? Why?
Definition
Arteries because of their large radius and low resistance
Term
What provides the bloods driving force when the ventricles are in diastole?
Definition
Arteries elastic properties
Term
True or false,

When the heart is contracting and emptying, the arteries are narrowing to push blood along to the rest of the body.
Definition
False, the arteries are filling up to provide driving force while the ventricles are in diastole.
Term
What is the systolic phase of blood pressure?
Definition
The peak pressure exerted by ejected blood on vessel walls
Term
What is diastolic pressure?
Definition
Minimum pressure In arteries when blood is draining downstream into other vessels.
Term
How could one measure pulse pressure?
Definition
Subtracting systolic and diastolic
Term
What is mean arterial pressure and how is it calculated?
Definition
The average driving pressure throughout cardiac cycles

Diastolic pressure + 1/3(pulse pressure)
Term
What regulates and controls mean arterial pressure?
Definition
Blood pressure reflexes
Term
Which blood vessel is known as the major resistance vessel?
Definition
Arterioles
Term
What is the result of the high pressure of arteriolar?
Definition
A large drop in the mean pressure between arteries and capillaries
Term
How do arterioles ultimately enhance blood flow?
Definition
By having high resistance which Declines pressure which then enhances the pressure gradient ultimately enhancing blood flow
Term
What two physiological functions does adjusting the arteriole radius accomplish?
Definition
Blood pressure regulation and variabally distribute cardiac output based on bodily need
Term
What term refers to the baseline of arteriole resistance?
Definition
Vascular tone
Term
True or false,

Arteriolar tone can be controlled by intrinsic and extrinsic controls?
Definition
True
Term
True or false,

Active hyperemia is an extrinsic control of vascular tone.
Definition
False,

Intrinsic
Term
True or false,

When blood pressure needs to be regulated, intrinsic controls come in handy.
Definition
False,

Extrinsic controls are important for blood pressure regulation
Term
How does one not sympathetically vasoconstrict during exercise?
Definition
Because skeletal and cardiac muscles have local mechanisms that can override the extrinsic controls
Term
What brain structure is responsible for sympathetic output to the arterioles?
Definition
Medulla
Term
Based off of the capillary structure, what 3 major physiological events are amplified?
Definition
The surface area benefits exchange
Diffusion distance is minimized
Large cross sectional area leads to slow blood velocity leading to maximal time for exchange
Term
How does the large cross sectional area of a capillary benefit it's physiology?
Definition
Lads to slower blood velocity this an increase in time for material exchange
Term
What are the two exchange mechanisms seen in capillaries?
Definition
Passive diffusion and bulk flow
Term
How does bulk flow generally work?
Definition
Protein free plasma flows out of the capillary, mixes with interstitial fluid, then reabsorbed
Term
What process helps distribute extra cellular fluid between plasma and interstitial fluid with the goal of maintaining blood pressure?
Definition
Bulk flow
Term
What are the differences between the two subprocesses of bulk flow?
Definition
Ultrafiltration - occurs when pressure inside is greater than that outside, thus, materials are forced outward

Reabsorption - pressure outside exceeds pressure inside and fluid is forced back inward
Term
Why does bulk flow specifically occur?
Definition
Because of the difference is hydrostatic pressure and colloid osmotic pressure between plasma and interstitial fluid.
Term
What forces pushes fluid out of capillary beds?
Definition
Capillary hydrostatic pressure
Term
What forces pull fluids back into capillaries?
Definition
Plasma colloid osmotic pressure
Term
Where does the excess fluid that is not reabsorbed during bulk flow end up?
Definition
Lymphatic system and then back to general circulation
Term
What three substances have the possibility of being picked up by the lymphatic system?
Definition
Excess fluid, leaked proteins, and bacteria from tissues
Term
At any one time, what percentage of the blood is contained within veins?
Definition
Sixty percent
Term
True or false,

Venules communicate mechanically with arterioles to regulate capillary flow.
Definition
False,

The communicate chemically
Term
What three venous actions help to counteract gravity during venous return?
Definition
One way venous valves
Venous vasoconstriction by sympathetic system
External compression by skeletal muscle contraction
Term
What determines total peripheral resistance?
Definition
Degree of arteriolar vasoconstriction
Term
What controls blood volume?
Definition
Kidneys
Term
What are the names of the receptors which help determin blood pressure needs?
Definition
Baroreceptors
Term
What is a short term fix to blood pressure?
Definition
Neutral control of cardiac output and Total peripheral resistance
Term
What is a long term fix to blood pressure?
Definition
Controlling total blood volume by regulating urine output and thirst
Term
What is the baroreceptor reflex? (general)
Definition
Short term reflex for regulating blood pressure
Term
Where are the baroreceptors who detect bp changes located?
Definition
Carotid sinus and aortic arch
Term
Once baroreceptors create a signal, where do these signals go?
Definition
Cardiac center of the medulla.
Term
What do calcium channel blockers do to the heart?
Definition
Decrease it's activity and cause vasodilation
Term
How does the anti hypertensive class alpha blocker work?
Definition
Dilates arterioles
Term
What effect does a beta blocker have on the heart?
Definition
Reduces heart rate and strength of contraction
Term
What is orthstatic hypotension and how does it arise?
Definition
Dramatic decrease in blood pressure when standing up too quickly caused by insufficient sympathetic stimulation
Term
How does vasogenic shock arise?
Definition
Widespread arteriole dilation
Term
What causes Neurogenic shock?
Definition
Defective neural vasoconstrictor tone
Term
How does cardiogenic shock arise?
Definition
When heart no longer pumps blood efficiently
Term
What type of shock do all others lead to?
Definition
Circulatory shock
Term
True or false,

The right and left pump blood with the same force but the left side pumps a higher volume.
Definition
False, exact opposit
Term
Which valves are associated with S1
Definition
Both Av valves
Term
What heart structure limits how much blood can flow back into the heart?
Definition
Epicardium
Term
What is the resting potential for pacemaker cells?
Definition
-60 mV
Term
Which chamber of the heart is blood pressure associated with?
Definition
Left ventricle
Term
How does the first heart sound compare with the second and why.
Definition
First is louder because for the increased pressure
Term
How does exercise affect stroke volume and esv?
Definition
Increases stroke volume, decreases esv
Term
Which sound would be affected by mitral valve defect?
Definition
Sound 1
Term
Why does stretching of cardiac fibers give stronger contractions? How does this compare to skeletal fibers?
Definition
Stretching cardiac tissue creates more cross bridges leading to stronger contractions unlike skeletal tissues
Term
True or false,

Cardiac output change must occur for there to be a blood flow change.
Definition
False
Term
How does weight gain affect vessel length?
Definition
You form more capillaries and increase the length of vessels, this you increase vascular resistance
Term
Where does one measure diastole from? Why?
Definition
The aorta because ventricular diastole is zero
Term
What does vessel compliance refer to?
Definition
How easily a vessel can stretch
Term
What does vessel elastance refer to?
Definition
How easily a vessel snaps back
Term
True or false,

During diastole, arterioles have a period of relaxation.
Definition
False,

Arterioles never relax due to vascular tone
Term
True or false,

If you extrinsic ally wanted to limit kidney function, you would vasoconstrict blood vessels.
Definition
True
Term
How will excess fluid affect your oncotic pressure?
Definition
It wont
Term
Which protein is mostly responsible for oncotic pressure?
Definition
Albumin
Term
True or False,

Only the parasympathetic nervous system operates under the two-neuron chain pathway
Definition
False,

They both do
Term
What division of the autonomic nervous system uses norepinephrine to stimulate its target organs?
Definition
Sympathetic
Term
Which type of valve close to prevent backflow from the right ventricle into the right atrium?
Definition
Tricuspid
Term
Why would you hear S1 with ventricular systole?
Definition
Because the AV valve is closing and your hear S1 and S2 with valve closing. The reason why it is S1 is because The AV valve would be the first one to close then your pulmonary/systemic valves would close correlating with S2
Term
True or false,

Pulse pressure is the maximum pressure exerted by arteries.
Definition
False
Term
What is the response by baroreceptors if blood pressure is elevated?
Definition
The increase their firing rate
Term
True or False,

Veins serve as a major blood reservior.
Definition
True
Term
If you applied NE to a single vessel, what would be the general response?
Definition
Increased resistance by decreasing blood flow
Term
Which chemical is released to by sympathetic fibers to cause vascular tone?
Definition
NE
Term
Which part of the brain links the CNS to the ANS?
Definition
Prefrontal area
Term
How does the adrenal medulla relate to the sympathetic system?
Definition
Sympathetic stimulation increases the secretion of E and NE which in turn reinforce sympathetic activity
Term
USE THE BLANK HEART DIAGRAM AND LIST THE ANATOMICAL STRUCTURES
Definition
alkdfa
Term
Why does blood flow through the coronary arteries during diastole and not systole?
Definition
Because of the high pressure associated with systole, the coronary arteries are compressed.
Term
True or False,

Blood is always flowing through the coronary arteries whether the heart is contracting or relaxing.
Definition
False,

Blood only flows through the heart while it is relaxing
Term
What is the formula for flow rate?
Definition
Flow rate = delta p (pressure gradient) / R (resistance)
Term
How would decreasing O2 levels influence blood flow?
Definition
It would bring about active hyperemia in order to raise blood O2 levels back to normal
Term
What is autoregulation of blood flow?
Definition
The body's intrinsic ability to maintain constant blood flow under abnormal pressure situations
Term
What instance is autoregulation of the blood of importance?
Definition
With the brain since it needs a constant supply of blood at all times in order to function properly.
Term
What is a metaarteriole? What is their function and how do they accomplish it?
Definition
A short vessel which links arterioles with venules. Their function is to act as a blood diverter. In other words, they block off portions of the capillary bed where blood may not be needed at a certain time. They accomplish this by constricting their precapillary sphincters.
Term
What is the main function of albumin?
Definition
To maintain the colloid osmotic pressure of the blood
Term
What is the main function of plasma globulins?
Definition
To transport ions, hormones, and lipids involved in helping the immune response
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