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Exam 3 Liver Function
Exam 3 Liver Function
50
Chemistry
Undergraduate 3
02/28/2015

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Term
Where does metabolic activity takes place at?
Definition
Within hepatocytes
Term
_______ deliver blood from the hepatic artery
Definition
Sinusoids
Term
What type of cells ingest bacteria/foreign materials?
Definition
Kupffer's cells
(Macrophages)
Term
What are the ducts that drain fluid called?
Definition
Canaliculi
Term
What is the functioning unit of the liver called?
Definition
Lobule
Term
True or False:
Ducts merge to form the common bile duct
Definition
True
Term
List the Functions of the Liver (4-5)
Definition
Excretory/Secretory
Synthesis
Detoxification
Storage
Term
What is the major heme waste product?
Definition
Bilirubin
Term
What is the amount of bilirubin that is produced daily?
Definition
200-300 mg
Term
What is the Normal Total Adult Bilirubin level in the Plasma?
Definition
0.2-1.2 mg/dL
Term
What is most of the normal total adult bilirubin made of?
Definition
Unconjugated
Term
What is the following considered:
RBC Destruction --> Heme --> Bilirubin --> +Albumin --> Unconjugated Bilirubin
Definition
Indirect
Term
What are all of the following examples of:
Result of RBC lysis (2-3 hours)
Albumin-bound
Indirect
Not Water Soluble
Not Excretable
Definition
Unconjugated
Term
What are all of the following examples of:
Formed in liver from unconjugated
Direct
Water soluble
Excretable
Converts to urobilinogen
Definition
Conjugated
Term
Name the disease:
Yellowish pigmentation in skin, eyes, and mucous membranes
Definition
Jaundice
Term
Jaundice will be apparent when bilirubin levels react what in the plasma?
Definition
2-3 mg/dL
Term
What do the following describe:
Increased Indirect
Normal Direct
No bilirubin in urine
Overproduction of bilirubin NOT associated with liver dysfunction
Definition
Prehepatic Jaundice
Term
What do the following describe:
Defective cellular uptake, transport, conjugation, or secretion
Definition
Hepatic Jaundice
Term
What do the following describe:
Obstruction of bile flow to kidneys
Positive Urine Bilirubin
Negative Urine Urobilinogen
Definition
Posthepatic Jaundice
Term
The following diseases are associated with which type of Jaundice?
Hemolytic anemias, transfusion reactions, sickle cell anemia, HDN
Definition
Prehepatic Jaundice
Term
What can HDN lead to?
Definition
Pathological Jaundice of the newborn
Term
What can you treat Kernicterus with?
Definition
Transfusion and/or phototherapy
Term
How soon will Physiological Jaundice of the newborn resolve?
Definition
7-10 days
Term
Breast Milk Jaundice is caused from interference of what 2 substances?
Definition
Pregnandiol or Progesterone
Term
The following diseases are associated with which type of Jaundice?
Physiological jaundice of the newborn
Break milk jaundice
Cirrhosis, hepatitis, cancer
Drug-induced toxicity
Autoimmune Diseases
Reye's
Definition
Hepatic Jaundice
Term
Reye's is associated with what levels or direct and indirect?
Definition
Increased Direct
Increased Indirect
Term
What type of Jaundice are the following diseases/conditions associated with?
Gallstones, tumors, clay-colored stools
Definition
Posthepatic Jaundice
Term
Which which type of Jaundice will you see an increase in the amount of bilirubin in the serum?
Definition
Posthepatic Jaundice
Term
Which which type of Jaundice will you see an increase in the levels of GGT & ALP?
Definition
Posthepatic Jaundice
Term
List 3 substances stored in the liver.
Definition
Glycogen
Iron
Vitamins
Term
List the endproduct of protein metabolism that is formed in the liver
Definition
Urea
Term
What type of hormones are produced in the liver?
Definition
Steroid
Term
Match the substance with the description:
Water soluble bilirubin
Definition
Conjugated bilirubin
Term
Match the substance with the description:
Normally found in the urine as a waste product
Definition
Urobilinogen
Term
Match the substance with the description:
Direct bilirubin
Definition
Conjugated bilirubin
Term
Match the substance with the description:
Formed as a result of RBC lysis
Definition
Unconjugated bilirubin
Term
Match the substance with the description:
Albumin-bound
Definition
Unconjugated bilirubin
Term
Match the substance with the description:
Bilirubin that is excretable into urine
Definition
Conjugated bilirubin
Term
Match the substance with the description:
Formed in the liver under enzyme action
Definition
Conjugated bilirubin
Term
Match the substance with the description:
Formed in the intestines under bacterial enzyme action
Definition
Urobilinogen
Term
Match the type of jaundice with the condition:
Breast milk jaundice
Definition
Hepatic jaundice
Term
Match the type of jaundice with the condition:
Gallstones
Definition
Posthepatic jaundice
Term
Match the type of jaundice with the condition:
Viral hepatitis
Definition
Hepatic jaundice
Term
Match the type of jaundice with the condition:
Hemolytic anemia
Definition
Prehepatic jaundice
Term
Match the type of jaundice with the condition:
Cirrhosis
Definition
Hepatic jaundice
Term
Match the type of jaundice with the condition:
Bile duct tumor
Definition
Posthepatic jaundice
Term
Match the type of jaundice with the condition:
Hemolytic disease of the newborn
Definition
Prehepatic jaundice
Term
Match the type of jaundice with the condition:
Physiologic jaundice of the newborn
Definition
Hepatic jaundice
Term
At what bilirubin level in the serum will jaundice become evident?
Definition
>2 mg/dL
Term
What term describes the deposit of bilirubin in the CNS of infants that may lead to brain damage and mental retardation?
Definition
Kernicterus
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