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Exam 3 Liver Disorders & Lab Analysis
Exam 3 Liver Disorders & Lab Analysis
72
Chemistry
Undergraduate 3
03/01/2015

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Cards

Term
With which Disorder is the following associated with:
[image]
Definition
Cirrhosis
Term
What is the main cause of a Fatty Liver?
Definition
Alcoholism
Term
What may a Fatty Liver progress to?
Definition
Alcoholic Hepatitis
Permanent Cirrhosis
Term
How would you describe Hepatitis?
Definition
Inflammation of the liver
Term
What Disorder are the following associated with?
Bacteria, parasites, radiation, alcohol, drugs, chemicals, toxins, Jaundice
Definition
Hepatitis
Term
Describe the chemical tests for Hepatitis in association with bilirubin, albumin, AST, and ALT
Definition
Increased Direct & Indirect Bilirubin
Positive Urine Bilirubin
Increased ALT & AST
Decreased Albumin
Term
What are the 2 leading causes of Cirrhosis?
Definition
Alcohol Abuse
Chronic HCV
Term
Cirrhosis causes what type of abilities of the liver to be reduced?
Definition
Synthesizing
Term
What will be increased and decreased in Cirrhosis?
Definition
Decreased Albumin
Decreased Clotting Factors
Increased GGT
Increased PT
Term
True or False:
Cirrhosis causes a decrease in albumin and clotting factors which leads to an increase in PT and bleeding disorders
Definition
True
Term
What type of electrophoresis pattern is associated with Cirrhosis?
Definition
Beta-Gamma Bridging
Term
What is the 12th leading cause of death in the United States of America?
Definition
Cirrhosis
Term
What can be attributable to HBV & HCV?
Definition
Tumors
Term
What is the marker for tumors due to liver disorders?
Definition
AFP
Term
What disorder is usually following a viral or URT infection?
Definition
Reye's Syndrome
Term
Which disorder is associated with aspirin use?
Definition
Reye's Syndrome
Term
Reye's Syndrome is associated with increased levels of what 3 substances?
Definition
Ammonia
ALT
AST
Term
What are most Drug-Induced Disorders of the Liver associated with?
Definition
Ethanol
Term
What over-the-counter drug is often associated with Drug-Induced Disorders of the Liver?
Definition
Acetaminophen
Term
Which disorder are the following attributed to:
Inherited iron storage disease
Sideroblastic anemia results
Pigmentation to skin
Definition
Hemochromatosis
Term
What type of stain helps visualize iron deposits?
Definition
Prussian Blue
Term
What method is the following consistent with?
Serum + Diazo Reagent --> Azobilirubin
Definition
Conjugated Bilirubin
Term
What method is the following consistent with?
Serum + Accelerator + Diazo Reagent -->
Azobilirubin
Definition
Total Bilirubin (Conjugated + Unconjugated)
Term
What methods is the following consistent with?
Azobilirubin + Alk Tartrate --> Blue color at 600 nm
Definition
Total Bilirubin (Conjugated + Unconjugated)
& Conjugated Bilirubin
Term
Serum + Diazo Reagent --> ?
Definition
Azobilirubin
Term
Serum + Accelerator + Diazo Reagent --> ?
Definition
Azobilirubin
Term
Azobilirubin + Alk Tartrate --> ?
Definition
Blue color at 600 nm
Term
Malloy & Evelyn method uses what?
Definition
Methanol Accelerator
Term
Jendrassik-Grof method uses what?
Definition
Caffeine Accelerator
Term
What is Delta Bilirubin?
Definition
Conjugated bilirubin bound to albumin
Term
What is Delta Bilirubin seen in?
Definition
Severe Liver Obstruction
Term
What does Delta Bilirubin react as in testing?
Definition
Conjugated Bilirubin
Term
Who should a Direct Spectrophotometry be used on?
Definition
Newborn Serum that does not contain carotinoids
Term
Direct Spectrophotometry - Absorbance at _______ is proportional to concentration
Definition
450 nm
Term
Direct Spectrophotometry - After the child is 1 month of age what method do you use?
Definition
Jendrassik-Grof Method
Term
What method measures light reflected from the skin?
Definition
Transcutaneous Method
Term
Who should the Transcutaneous Method be used on?
Definition
Newborn Serum that does not contain carotinoids
Term
Where is urobilinogen detected at?
Definition
Urine
Feces
Term
What reagent do you use with urobilinogen to get a colored compound?
Definition
Ehrlich's Reagent
Term
Low levels of what is seen in malnutrition or starvation?
Definition
Albumin
Term
A prolonged PT indicates severe what?
Definition
diffuse liver disease
Term
Is a prolonged PT a good prognosis or a bad prognosis?
Definition
bad prognosis
Term
You will see increased levels of what in Reye's Syndrome, Cirrhosis, Drug Toxicity, and Hepatoma?
Definition
Ammonia
Term
What can you use Ammonia to assess?
Definition
Detoxification and Excretion Function of the Liver
Term
Encephalopathy =
Definition
Hepatic Coma
Term
Enzymes are considered indicators of ____ _____ rather than cell function?
Definition
cell damage
Term
What type of disorder are the following associated with:
ALP: N
GGT: N
AST/ALT: N
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: N
Urine Bilirubin: Negative
Urine Urobilinogen: Increased
Definition
Prehepatic
Term
What type of disorder are the following associated with:
ALP: Increased
GGT: Increased
AST/ALT: VERY Increased
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: Increased
Urine Bilirubin: Positive
Urine Urobilinogen: N/Increased
Definition
Hepatic
Term
What type of disorder are the following associated with:
ALP: N/Increased
GGT: VERY Increased
AST/ALT: Increased
Albumin: Decreased
Total Bilirubin: Increased
Direct Bilirubin: N/Increased
Urine Bilirubin: Various
Urine Urobilinogen: Various
Definition
Alcoholic Hepatitis
Term
What type of disorder are the following associated with:
ALP: VERY Increased
GGT: Very Increased
AST/ALT: Increased
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: Increased
Urine Bilirubin: Positive
Urine Urobilinogen: Decreased
Definition
Obstruction
Term
Match the findings with the condition:
Inherited iron storage disease causing sideroblastic anemia
Definition
Hemochromatosis
Term
Match the findings with the condition:
Leading cause of cirrhosis; elevated GGT, beta-gamma bridging
Definition
Alcoholism
Term
Match the findings with the condition:
Highest levels of AST and ALT seen
Definition
Viral hepatitis
Term
Match the findings with the condition:
Liver disease following the flu; elevated ammonia
Definition
Reye's syndrome
Term
Match the findings with the condition:
Alpha fetoprotein used as a marker
Definition
Hepatoma
Term
Match the findings with the condition:
Gallstones cause the appearance of pale stools
Definition
Obstructive jaundice
Term
Match the bilirubin results with the most likely condition:
Posthepatic jaundice
Definition
Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
Term
Match the bilirubin results with the most likely condition:
Obstruction
Definition
Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
Term
Match the bilirubin results with the most likely condition:
Hemolytic anemia
Definition
Increased indirect bilirubin; increased urine urobilinogen
Term
Match the bilirubin results with the most likely condition:
Viral hepatitis
Definition
Increased direct & Increased Indirect Bilirubin; positive urine bilirubin and urobilinogen
Term
Match the bilirubin results with the most likely condition:
Gallstones
Definition
Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
Term
Match the bilirubin results with the most likely condition:
Prehepatic jaundice
Definition
Incrased indirect bilirubin; increased urine urobilinogen
Term
What over-the-counter drug is highly toxic to the liver?
Definition
acetaminophen
Term
What protein is decreased in liver disease, but also decreased in malnutrition and starvation?
Definition
Albumin
Term
Name the coagulation test that, when prolonged, may be an indicator of diffuse liver disease.
Definition
PT
Term
What liver enzyme is commonly elevated in bile duct obstructions?
Definition
ALP & GGT
Term
What is the purpose of the caffeine accelerator in the J-G method for total bilirubin?
Definition
Converts indirect bilirubin to water soluble form
Term
How should specimens for bilirubin analysis be stored?
Definition
Protect from light
Term
How will hemolysis affect test results?
Definition
Falsely decreases
Term
What methodology is commonly used to test for bilirubin in the serum of newborns?
Definition
Direct spectro
Term
What is Delta bilirubin?
Definition
Direct bilirubin bound to albumin
Term
In what condition will delta bilirubin be elevated?
Definition
Severe obstruction
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