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Exam 3 Intro to Endocrinology, Hypothalamus, & Pituitary
Exam 3 Intro to Endocrinology, Hypothalamus, & Pituitary Hormones
119
Chemistry
Undergraduate 3
03/01/2015

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Term
What do the endocrine glands produce and secrete?
Definition
Hormones
Term
How do hormones travel in the body?
Definition
Bloodstream
Term
Where do hormones travel to in the body?
Definition
Targets specific tissue/organ/gland
Term
Define Tropic Hormone
Definition
Causes its target cell to secrete its own specific hormone
Term
Define Effector Hormone
Definition
Causes a direct effect on the target tissue
Term
5 Functions of Hormones
Definition
*Metabolism & Production of Energy
*Maintain homeostasis & growth
*Sexual maturation & Reproduction
*Resistance & Response to stress
*Affects moods
Term
Which class of hormone does the following describe:
Water insoluble
Requires a carrier protein
Slower production; Sustained effect
Definition
Steroid Hormones
Term
Which class of hormone does the following describe:
Water Soluble
No carrier protein required
Quicker action
Shorter Half-Life
Definition
Protein Hormones
Term
Which class of hormone enters the target cell nucleus and binds to nuclear chromatin?
Definition
Steroid Hormones
Term
Which class of hormone induces formation of mRNA which initiates synthesis of proteins, enzymes, etc.
Definition
Steroid Hormones
Term
What are Steroid Hormones derived from?
Definition
Cholesterol
Term
Which class of hormone binds with specific receptors on the cell membrane?
Definition
Protein Hormones
Term
Protein hormones can activate the conversion of ATP to ______, which activates other enzymes to produce a rapid biologic effect
Definition
cAMP
Term
Protein hormones can stimulate _____ levels in cytoplasm. This then activates other enzymes to produce a biological effect.
Definition
Calcium
Term
Which class of hormones shares properties of both steroid and protein classes?
Definition
Amines
Term
Define Open Loop Feedback Mechanism
Definition
A decrease in one substance causes the increase of another substance or vise versa
Term
A drop in serum glucose causes the rise of ______
Definition
Glucagon
Term
A rise in serum glucose causes the rise of ______
Definition
Insulin
Term
What type of factors come out of the Hypothalamus and act on the Anterior Pituitary?
Definition
Inhibiting & Releasing Factors
Term
What type of factors come out of the Hypothalamus and act on the Posterior Pituitary?
Definition
ADH & Oxytocin
Term
What type of factors come out of the Anterior Pituitary and act on the Thyroid?
Definition
TSH
Term
What type of factors come out of the Anterior Pituitary and act on the Breasts?
Definition
PRL
Term
What type of factors come out of the Anterior Pituitary and act on the Adrenal Cortex?
Definition
ACTH
Term
What type of factors come out of the Anterior Pituitary and act on the Ovaries/Testes?
Definition
FSH/LH
Term
What type of factors come out of the Anterior Pituitary and act in/on General?
Definition
GH
Term
What type of factors come out of the Adrenal Medulla?
Definition
Epinephrine
Norepinephrine
Dopamine
Term
What is the result of the release of TSH?
Definition
T3T4
Term
What is the result of the release of PRL?
Definition
Milk
Term
What is the result of the release of GH?
Definition
Growth
Term
What is the result of the release of FSH/LH - males?
Definition
Testosterone
Term
What is the result of the release of FSH/LH - females?
Definition
Estrogen
Progesterone
Term
What type of factors come out of the Posterior Pituitary and act on the kidneys?
Definition
ADH
Term
What is the result of the release of TSH on the Parathyroid?
Definition
Calcium regulation
Term
What is the result of ADH release on the kidneys?
Definition
Water retention
Term
What is the result of the release of ACTH on the Adrenal Cortex?
Definition
Cortisol
Androgens
Aldosterone
Term
What 2 substances do the kidneys release and regulate?
Definition
Renin
Erythropoietin
Term
What 2 substances do the pancreas release and regulate?
Definition
Insulin
Glucagon
Term
What 2 areas of the human body does Oxytocin have an effect on?
Definition
Uterus/Breast
Term
Which hormone is the following:
Effector
Target Organ: Muscle, bone, liver, adipose, others
Action: General growth & Metabolic regulation
Definition
GH
Term
Which hormone is the following:
Effector
Target Organ: Breast and others
Action: Lactation
Definition
PRL
Term
Which hormone is the following:
Tropic
Target Organ:Thyroid
Action: Thyroid hormone synthesis/release
Definition
TSH
Term
Which hormone is the following:
Tropic
Target Organ: Ovary, Testes
Action: Estrogen synthesis, spermatogenesis
Definition
FSH
Term
Which hormone is the following:
Tropic
Target Organ: Ovary, Testes
Action: Ovulation, Testosterone synthesis
Definition
LH
Term
Which hormone is the following:
Tropic
Target Organ: Adrenal cortex, Skin
Action: Corticoid synthesis, pigmentation
Definition
ACTH
Term
What is considered the neural connection to the other brain centers; It is connected to the pituitary by the pituitary stalk
Definition
Hypothalamus
Term
True or False:
Hormone levels in the hypothalamus are too small to quantitate
Definition
True
Term
What does the Hypothalamus secrete?
Definition
Releasing and Inhibiting Hormones
Term
Dysfunction of the Hypothalamus results in what?
Definition
Tumors, inflammation, and degenerative diseases
Term
The posterior pituitary secretes what 2 hormones?
Definition
Vasopressin (ADH)
Oxytocin
Term
The anterior pituitary secretes what 6 hormones?
Definition
GH
FSH
LH
TSH
ACTH
PRL
Term
Which hormone is responsible for uterine contractions and lactation?
Definition
Oxytocin
Term
Vasopressin/ADH is triggered by what?
Definition
Increased serum osmolality or blood pressure
Term
What does Vasopressin/ADH cause to happen in the distal tubules and collecting ducts?
Definition
Water retention
Term
What hormone constricts smooth muscle to increase blood pressure?
Definition
Vasopressin/ADH
Term
What is Vasopressin/ADH inhibited by?
Definition
Cold, drugs, caffeine, & alcohol
Term
What disorder/disease is associated with HYPOsecretion of Vasopressin/ADH?
Definition
Diabetes insipidus
Term
What disorder is associated with HYPERsecretion of Vasopressin/ADH?
Definition
Too much water retention
Term
The following are associated with what type of secretion of Vasopressin/ADH:
Increased Na
Increased Plasma Oosmolaltiy
High Volume Dilute Urine
Dehydration
Definition
HYPOsecretion
Term
What disease/disorder is associated with the following:
Increased Na
Increased Plasma Oosmolaltiy
High Volume Dilute Urine
Dehydration
Definition
Diabetes insipidus
Term
The following are associated with what type of secretion of Vasopressin/ADH:
Decreased osmolality
Electrolyte imbalances
Increased Blood Pressure
Low Volume Concentration Urine
Definition
HYPERsecretion
Term
What hormone does the following:
Helps bones lengthen and expand
Helps transport and induce production of AA in cells
Aids in glucose metabolism & lipolysis
Definition
Growth Hormone
Term
Which hormone targets cartilage, adipose tissue, and striated muscle?
Definition
Growth Hormone
Term
True or False:
Other pituitary hormones must be present for GH to work
Definition
True
Term
True or False:
GH is released in pulses every 4-6 hours
Definition
False
Term
True or False:
GH is released in pulses every 2-3 hours
Definition
True
Term
What is the result of HYPOsecretion of GH in Kids?
Definition
Slow growth development
Hypoglycemia
Term
What is the result of HYPOsecretion of GH in Adults?
Definition
Tiredness, weight gain, depression
Term
What is the result of HYPERsecretion of GH in Kids?
Definition
Gigantism with retardation
Term
What is the result of HYPERsecretion of GH in Adults?
Definition
Acromegaly (bone and tissue overgrowth); usually a tumor
Term
Which hormone initiates and maintains postpartum lactation?
Definition
Prolactin
Term
The following symptoms are associated with which condition?
Amenorrhea
Erectile Dysfunction
Infertility
Headache
Definition
Prolactinemia
Term
A deficiency in Prolactin will result in what?
Definition
Lack of postpartum lactation
Term
You use dilutional prolactin to avoid what?
Definition
Prozone effect
Term
Thyroid-Stimulating Hormone tells the thyroid gland to secrete what?
Definition
T3
T4
Term
In women, what does Luteinizing Hormone regulate and synthesize?
Definition
Ovulation
Progesterone synthesis
Term
In men, what does Luteinizing Hormone stimulate?
Definition
Testosterone production
Term
What does the Adrenocorticotropin Hormone stimulate the adrenal cortex to produce?
Definition
Glucocorticoids, primarily cortisol
Term
What is considered the neural connection to the other brain centers; It is connected to the pituitary by the pituitary stalk
Definition
Hypothalamus
Term
True or False:
Hormone levels in the hypothalamus are too small to quantitate
Definition
True
Term
What does the Hypothalamus secrete?
Definition
Releasing and Inhibiting Hormones
Term
Dysfunction of the Hypothalamus results in what?
Definition
Tumors, inflammation, and degenerative diseases
Term
The posterior pituitary secretes what 2 hormones?
Definition
Vasopressin (ADH)
Oxytocin
Term
The anterior pituitary secretes what 6 hormones?
Definition
GH
FSH
LH
TSH
ACTH
PRL
Term
Synthetic Oxytocin is now being used to do what?
Definition
Induce labor
Term
Vasopressin/ADH is triggered by what?
Definition
Increased serum osmolality or blood pressure
Term
What does Vasopressin/ADH cause to happen in the distal tubules and collecting ducts?
Definition
Water retention
Term
What hormone constricts smooth muscle to increase blood pressure?
Definition
Vasopressin/ADH
Term
What is Vasopressin/ADH inhibited by?
Definition
Cold, drugs, caffeine, & alcohol
Term
What disorder/disease is associated with HYPOsecretion of Vasopressin/ADH?
Definition
Diabetes insipidus
Term
What disorder is associated with HYPERsecretion of Vasopressin/ADH?
Definition
Too much water retention
Term
What is the result of HYPOsecretion of GH in Kids?
Definition
Slow growth development
Hypoglycemia
Term
What is the result of HYPOsecretion of GH in Adults?
Definition
Tiredness, weight gain, depression
Term
What is the result of HYPERsecretion of GH in Kids?
Definition
Gigantism with retardation
Term
What is the result of HYPERsecretion of GH in Adults?
Definition
Acromegaly (bone and tissue overgrowth); usually a tumor
Term
Which hormone initiates and maintains postpartum lactation?
Definition
Prolactin
Term
The following symptoms are associated with which condition?
Amenorrhea
Erectile Dysfunction
Infertility
Headache
Definition
Prolactinemia
Term
A deficiency in Prolactin will result in what?
Definition
Lack of postpartum lactation
Term
You use dilutional prolactin to avoid what?
Definition
Prozone
Term
Thyroid-Stimulating Hormone tells the thyroid gland to secrete what?
Definition
T3
T4
Term
In men, what does Follicle-Stimulating Hormone stimulate?
Definition
Spermatogenesis
Term
In women, what does Follicle-Stimulating Hormone stimulate?
Definition
Estrogen synthesis
Term
What does the Adrenocorticotropin Hormone stimulate the adrenal cortex to produce?
Definition
Glucocorticoids, primarily cortisol
Term
Differentiate a tropic from an effector hormone.
Definition
*Tropic hormones cause their target gland to secrete another hormone.
* Effector hormones have a direct effect on their targets with no subsequent hormone secreted
Term
Describe the mechanism of action of both steroid and protein classes of hormones.
Definition
*Steroid hormones cause production of mRNA.
*Protein hormones either trigger cAMP production or cause an influx of calcium
Term
Describe a simple negative feedback loop of hormone regulation.
Definition
The fall of one substance causes a rise in another
Term
Define panhypopituitarism
Definition
All hormones produced by the pituitary are decreased
Term
Name the two hormones produced by the hypothalamus, but stored and secreted by the posterior pituitary.
Definition
ADH (vasopressin)
Oxytocin
Term
Match each of the hormones listed with its target organ and/or function:
Targets distal tubules and collecting ducts
Definition
Vasopressin
Term
Match each of the hormones listed with its target organ and/or function:
Targets bones, cartilage, adipose tissue
Definition
GH
Term
Match each of the hormones listed with its target organ and/or function:
Stimulates uterine contractions
Definition
Oxytocin
Term
Match each of the hormones listed with its target organ and/or function:
Turns on the thyroid gland
Definition
TSH
Term
Match each of the hormones listed with its target organ and/or function:
Triggers production of estrogen and testosterone
Definition
FSH/LH
Term
Match each of the hormones listed with its target organ and/or function:
Aids in postpartum milk production
Definition
Prolactin
Term
Match each of the hormones listed with its target organ and/or function:
Stimulates the production of cortisol
Definition
ACTH
Term
Match each of the hormones listed with its target organ and/or function:
Causes water retention
Definition
Vasopressin
Term
Match each of the hormones listed with its target organ and/or function:
Targets the ovaries and testes
Definition
FSH/LH
Term
Match each of the hormones listed with its target organ and/or function:
Targets the adrenal cortex.
Definition
ACTH
Term
What disease is associated with a deficiency of ADH, polyuria and dehydration?
Definition
Diabetes insipidus
Term
What condition is associated with overproduction of ACTH and stimulation of the adrenal cortex?
Definition
Cushing's
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