Term
| membrane characteristics (5) |
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Definition
permeability barrier
compartmentalization
transport processes
adhesion/cell to cell communication
detection by signal (transduction) |
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Term
| 3 classes of membrane lipids |
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Definition
1. Phospholipids
Phophotidyl - choline
ethanolamine
serine
inositol
Sphingolipids
2.Glycolipids: sugar head/sphingosine back bone
3. Sterols: cholesterol |
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Term
|
Definition
1.integral - single/multi pass and multi subunit
2. peripheral - not covalent
3. lipid - anchored by polar head (covalent) |
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Term
| movement of membrane proteins (3) |
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Definition
1. rotation
2. lateral diffusion (FRAP)
3. transverse diffusion |
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Term
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Definition
| Florescene Recovery After Photobleaching |
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Term
| regulation of lipid fluidity (3) |
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Definition
1. fatty acid saturation: cis/trans db
2. fatty acid tail length: longer=less fluid
3. cholesterol content: little=more fluid |
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Term
| 3 mechanisms of membrane transport |
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Definition
1. simple diffusion
2. facilitated : with gradient
3. active: against gradient |
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Term
| types of coupled transport (3) |
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Definition
1. uniport
2. symport
3. antiport |
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Term
| Resting membrane potential |
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Definition
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Term
|
Definition
1. 3 Na bind
2. autophosphorylation: ATP cleaved
3. open to outside and Na leave
4. 2 K bind from cytosol
5. autodephosphorylation/K comes inside |
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Term
| Na/Glucose symport sequence |
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Definition
1.2 Na bind outside the cell
2.nook for 1 glucose to bind
3. open to inside and Na release then pumped out
4. Glucose release into cell
unfavorable glucose movement |
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Term
|
Definition
| Cystic Fibrosis Transmembrane Conductance Regulator (chloride pump doesn't work) |
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Term
|
Definition
light harvesting
electrons flow from water/protons pumped
ATP produced
Water oxidized
NADP and complexes reduced |
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Term
|
Definition
carbon fixation in stroma
CO2 --> glucose
calvin cycle |
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Term
| electron flow in light rxns (Z scheme) |
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Definition
H2O->MSP->P680 in PSII-> series of carriers-> P700 in PSI-> NADP+
MSP= Manganese stabilizing protein |
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Term
|
Definition
continuous tubes
hydroxylation/detox
lipid steroid synthesis
calcium sequestration
glycogen catabolism |
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Term
|
Definition
stacked sheets with ribosome
protein synthesis
core glycosylation |
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Term
cotranslational transport
every good senator lies plenty |
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Definition
er
golgi
secretory
lysosome
plasma membrane |
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Term
|
Definition
| signal recognition particle |
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Term
| address of growing proteins |
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Definition
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Term
| ribosome binding to ER sequence (7) |
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Definition
1. SRP binds to ER siganl sequence
2. SRP binds to SRP receptor on ER membrane
3. Ribsome binds to ribosome receptor
4. translocon allows aa sequence to thread
5. bind GTP and Jhook in pore
6. GTP hydrolysis/SRP off/translation continues
7. siganl peptidase clease ER signal sequence |
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|
Term
port translational destination
not many cats play carefully |
|
Definition
nucleus
mitochondria
cytosol
peroxisome
chloroplast |
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Term
| mannose-6-phosphate tag sequence (6) |
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Definition
1. cotranslational and glycosylation
2. M6P tag added in cis golgi
3. binds to receptor in trans
4. buds off
5. release from receptor and fuse with endosome
6. receptor recycled and goes to lysosome |
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Term
|
Definition
triskelion monomer
forms pit to help with endocytosis
forms cage
postranslational |
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Term
|
Definition
LDL - more lipid than protein
packaged in liver
HDL - more protein than lipid
packaged in adipocytes |
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Term
| Familial Hypercholesterolemia |
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Definition
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Term
|
Definition
| uses catalase to rid of radicals (H2O2) |
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Term
| ion concentration in and out of cell |
|
Definition
high inside K
high outside everything else |
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Term
| voltage gated Na/K sequence |
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Definition
1. rest: -70 mV and all channels closed
2. depolarization: Na open and influx/ must get to -40mV
3. repolarization: Na inactive/ K open and go to +40mV
4. hyperpolarization: K remain open/Na inactive to -80 mV |
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Term
|
Definition
Excitatory post synaptic potential
once reach axon terminal, Ca allows ACh to secrete out and bind to AChR on target cell (AChR=Na channel) |
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Term
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Definition
Botulinum Toxin
block ACh release in facial muscle |
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Term
|
Definition
| blocks AChR = rapid contractions |
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Term
|
Definition
1. degradation (AChE degrades ACh)
2. reuptake |
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Term
Dopamine Transporter
Serotonin Reuptake |
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Definition
blocked by cocaine
blocked by SSRI |
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Term
|
Definition
allows propagation to go longer/faster
node of ranvier
saltatory conduction |
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Term
|
Definition
receptor ligand binding
signal transduction via 2ndary messangers (Ca and cAMP)
cellular responses |
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Term
|
Definition
G protein coupled receptor
extracellular ligand binding site
ctyosolic Gprotein binding site
a,b,g subunits
ATP on a unit
conformation change when ligand binds
allosteric activation |
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Term
| G protein/ cAMP in glycogen catabolism |
|
Definition
adrenline binds
a unit binds to adenylyl cyclase ATP
cAMP (lots) forms
cAMP activates PKA->phosphorylase kinase-> phosphorylase a/b -> cleavage of terminal glucose |
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Term
|
Definition
1.microtubules: tubulin 25nm/vesicle transport
2.actin filaments: actin 7nm/ transport and contraction
3.intermediate filaments: tissue specific 10nm/structure |
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Term
| junction and cytoskeletal assosciation |
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Definition
1.tight: none
2.adhering: actin
3.desmosomes: intermediate
4.gap: none |
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Term
|
Definition
control aq salt movement
most apical
belt
prevent lateral diffusion |
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Term
|
Definition
adhesion btwn cells
continuous plaque around cell |
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Term
|
Definition
adhesion
bound by cadherins
calcium dependent
plaque=dense protein
wormy=intermediate |
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Term
|
Definition
| aq channel 6 connexin = 1 connexon 2 connexon = gap junction |
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Term
|
Definition
fibrous proteins (collagen/elastin)
proteoglycan and GAGS
glycoprotein |
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Term
|
Definition
rope like fibers
collagen = triple a helix
elastin = loose coils
fibroblasts = built/secretes fibrous proteins |
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Term
|
Definition
made of many GAG chains
polar sugars highly hydrated
GAG=glycosaminoglycan
1.condrotin sulfate
2.keratin sulfate
3.hyaluronate |
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Term
|
Definition
fibronectin= 2 strands linked by disulfide bonds (not in basal lamina)
laminin= 3 parts used in basal lamina
integrin= fibronectin and laminin receptor |
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Term
|
Definition
focal adhesion=integrin link ECM by actin filaments
hemidesmosome=integrin to intermediate filaments |
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