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Exam 3
thyroid, parathyroid, corticosteroids, hematologic
83
Pharmacology
Graduate
10/03/2014

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Term
Aspirin, ibuprofen, NSAID's
Definition
inhibit COX1 and 2--no prostaglandins
Term
Acetaminophen
Definition
inhibits prostaglandins only in CNS
Term
Ketorolac (Toradol)
Definition
injectable NSAID
Term
Celocoxib, Rofecoxib, Valdecoxib
Definition
COX2 inhibitors
Term
Lidocaine
Definition
local anesthetic--blocks sodium channels
class I antiarrhythmic
Term
Morphine, Codeine, Fentanyl, Heroin, Hydrocodone, Hydromorphone, meperidone, methadone, oxycodone
Definition
opioid agonists (strong analgesics)
Term
Pentazocine, buprenorphine, butorphanol, tramadol
Definition
partial opioid agonists
Term
amitriptyline
Definition
antidepressant used for neurogenic pain
Term
carbamazepine, gabapentin, pregabalin
Definition
anticonvulsants for neurogenic pain
Term
hydrochlorothiazide
Definition
diuretic (antihypertensive, CHF)
Term
furosemide (lasix)
Definition
diuretic (antihypertensive, CHF)
Term
spironolactone (aldactone)
Definition
diuretic (antihypertensive, CHF)
Term
reserpine
Definition
depletes central and peripheral epi,norepi, dopamine (antihypertensive)
Term
methyldopa
Definition
central acting alpha2 agonist (antihypertensive)
Term
clonidine
Definition
central acting alpha 2 agonist (antihypertensive)
Term
prazosin (minipress)
Definition
alpha1 blocker (antihypertensive)
Term
doxazosin (cardura)
Definition
alpha1 blocker (antihypertensive)
Term
terazosin
Definition
alpha1 blocker (antihypertensive)
Term
propanolol
Definition
beta blocker (antihypertensive, antianginal, class II antiarrhythmic)
Term
nadolol
Definition
beta blocker (antihypertensive, antianginal)
Term
timolol
Definition
beta blocker (antihypertensive, antianginal)
Term
pindolol
Definition
beta blocker (antihypertensive)
Term
atenolol
Definition
beta blocker (antihypertensive, antianginal)
Term
metoprolol
Definition
beta blocker (antihypertensive, antianginal, CHF)
Term
acebutolol
Definition
beta blocker (antihypertensive, class II antiarrhythmic)
Term
labetalol
Definition
alpha1/beta blocker and NO releasing beta blocker (antihypertensive)
Term
nebivolol
Definition
alpha1/beta blocker and NO releasing beta blocker (antihypertensive)
Term
verapamil
Definition
calcium channel blocker (antihypertensive, antianginal)
Term
nifedipine
Definition
calcium channel blocker (antihypertensive, antianginal)
Term
captopril
Definition
ACE inhibitor (antihypertensive, CHF)
Term
losartan
Definition
angiotensin II receptor blocker (antihypertensive, CHF)
Term
lovastatin
Definition
HMG-CoA reductase inhibitor
Term
nitroglycerin
Definition
nitrate, direct vasodilator (antianginal, CHF)
Term
digoxin
Definition
digitalis glycoside (CHF)
Term
dobutamine
Definition
non-glycoside inotropic agent (CHF)
Term
dopamine
Definition
non-glycoside inotropic agent (CHF)
Term
esmolol
Definition
beta blocker (class II antiarrhythmic)
Term
levothyroxine
Definition
synthetic T4 (hypothyroidism)
Term
131 I
Definition
hyperthyroidism
Term
propylthiouracil
Definition
thionamide--inhibits iodination and coupling of iodotyrosines, type 1 deiodinase inhibitor
(hyperthyroidism)
Term
methimazole (tapazole)
Definition
thionamide--inhibits iodination and coupling of iodotyrosines (hyperthyroidism)
Term
KI (Lugol's solution)
Definition
overloads iodide transporter, inhibits release of pre-formed hormone (hyperthyroidism)
Term
alendronate (fosamax)
Definition
bisphosphonate (osteoporosis, Paget's Disease)
Term
risedronate (actonel)
Definition
bisphosphonate (osteoporosis, Paget's Disease)
Term
ibandronate (boniva)
Definition
bisphosphonate (osteoporosis)
Term
zoledronic acid (relclast, zometa)
Definition
bisphosphonate (osteoporosis, hypercalcemia, Paget's Disease)
Term
raloxifene
Definition
bone estrogen receptor agonist (postmenopausal osteoporosis)
Term
calcitriol (vit D)
Definition
osteoporosis, hypoparathyroidism
Term
calcitonin
Definition
decreases osteoclast activity and increases Ca excretion by kidney (hypercalcemia, Paget's Disease, osteoporosis)
Term
pamidronate
Definition
bisphosphonate (hypercalcemia of malignancy, Paget's Disease)
Term
hydrocortisone (cortisol, cortaid)
Definition
short acting glucocorticoid (adrenocortical insufficiency; anti-inflammatory)
Term
prednisone (intensol)
Definition
intermediate acting glucocorticoid (allergies, autoimmune disorders)
Term
triamcinolone (nasacort)
Definition
intermediate acting glucocorticoid (aersolized, topical)
Term
dexamethasone (baycadron)
Definition
long acting glucocorticoid (systemic anti-inflammatory)
Term
fludrocorticosone
Definition
mineralcorticoid (adrenalcortical insufficiency--addison's disease)
Term
spironolactone (aldactone)
Definition
competitive aldosterone antagonist (edema, hypertension, CHF)
Term
cosyntropin (cortrosyn)
Definition
synthetic ACTH (diagnostic test for adrenocortical insufficiency)
Term
aspirin
Definition
antiplatelet--irreversible COX inhibitor (MI, thrombosis)
Term
dipyridamole (persantine)
Definition
antiplatelet--phosphodiesterase inhibitor, platelet adhesion inhibitor (thrombosis)
Term
clopidrogel (plavix)
Definition
antiplatelet--irreversibly binds to ADP receptor (MI, stroke, vascular death)
Term
heparin (hep-lock)
enoxaparin sodium (lovenox)
Definition
anticoagulant--binds antithrombin III (venous/arterial thromboembolic disease, extracorporeal circulation, pregnancy, IV catheters)
Term
protamine sulfate
Definition
binds heparin (heparin overdose)
Term
warfarin sodium (coumadin)
Definition
anticoagulant--vit. K epoxide reductase inhibitor--inhibits factor II, VII, IX, X, protein C and S (venous/arterial thromboembolic disease, extracorporeal circulation, IV catheters)
Term
lepirudin (refludan)
Definition
anticoagulant--blocks thrombin (treatment for heparin-induced thrombocytopenia)
Term
urokinase (abbokinase)
Definition
fibrinolytic--cleaves plasminogen to plasmin (thrombosis, MI)
Term
alteplase (activase)
Definition
fibrinolytic--cleaves plasminogen to plasmin (thrombosis, MI)
Term
aminocaproic acid (amicar)
Definition
inhibits plasmin (overactive fibrinolysis)
Term
factor VIII (hemofil M)
Definition
hemostatic--converts prothrombin to thrombin (hemophilia A)
Term
factor IX (bebuline)
Definition
hemostatic--converts prothrombin to thrombin (hemophilia B)
Term
phytonadione (mephyton)
Definition
hemostatic--vit. K--required for synth of factors II, VII, IX, X
(vit. K deficiency, hypoprothrombinemia, newborn hemorrhagic disease)
Term
iron
Definition
iron deficiency in microcytic anemias
Term
folic acid
Definition
megaloblastic anemia
Term
vit. B12 (cyanocabalamin, hydroxocobalamin)
Definition
megaloblastic anemia, pernicious anemia
Term
epoetin alfa (erythropoietin, EPO, Epogen, procrit)
Definition
growth and differentiation of erythrocytes (chronic anemias--AIDS or cancer)
Term
filgrastim (G-CSF)
Definition
growth and differentiation of neutrophils (neutropenics from chemo or HIV)
Term
sargramostim (GM-CSF; leukine)
Definition
growth and differentiation of granulocytes and macrophages (cancer patients or after bone marrow transplant)
Term
oprelvekin (interleukin 11; neumega)
Definition
growth and differentiation of megakaryocytes and platelets (thrombocytopenia in cancer patients)
Term
metyrapone (metopirone)
Definition
11 B-hydroxylase inhibitor--inhibits cortisol and aldosterone production (Cushing's)
Term
ketoconozale (nizoral)
Definition
17 alpha hydroxylase inhibitor--blocks all steroid synthesis (Cushing's disease)
anti-fungal
Term
Conn's Syndrome
Definition
hyperaldosteronism
Term
Addison's Disease
Definition
adrenocortical insufficiency
Term
Cushing's Syndrome
Definition
hypercortisolism/hyperadrenocorticism
Term
deferoxamine mesylate (desferal)
Definition
iron overdose
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