Term
| all new AEDs are less terotegenic except |
|
Definition
|
|
Term
| the new AEDS have what improved things comapred to the 1st gen? -4 |
|
Definition
PK
less CYP
less EPS
less sedation |
|
|
Term
| this drug can be used in neonates and older |
|
Definition
|
|
Term
| these drugs are approved for children >10 yrs old-2 |
|
Definition
|
|
Term
| which drug has risk of liver tox in children <2 |
|
Definition
|
|
Term
| this drug can be used for absence seizure with children >2 |
|
Definition
|
|
Term
| what are the 2 meds for absence seizures |
|
Definition
|
|
Term
| what meds cna be used for lennox gastaut-2 |
|
Definition
|
|
Term
| topiramate can be used as monotherapy in what age |
|
Definition
|
|
Term
oxcarbamezapine is adjunst for what age?
monotherapy? |
|
Definition
|
|
Term
| Levetiracetam shoudl be used in what age |
|
Definition
|
|
Term
| which drug isnt approved for use in children |
|
Definition
|
|
Term
| factors that imrpove successful AED withdrawl- |
|
Definition
seizure free 2 yrs
complete control in 1 yr
age>2, <35
only 1 type of seizure
normal EEG while on therapy |
|
|
Term
| withdrawl should be done over _ months- |
|
Definition
|
|
Term
| the acute dose depednt ADEs-2 |
|
Definition
neutoxic- sedation, dizzy
cognition impairment |
|
|
Term
| what classic drug is greater impair of cognition? which is least |
|
Definition
|
|
Term
| which new AED causes most cognitive impair? |
|
Definition
|
|
Term
|
Definition
|
|
Term
long term osteoporis is assoc with
what is the treatment? |
|
Definition
the classical AEDS
Ca + Vit D |
|
|
Term
| for ppl with epilepsy- is ther an increased risk of suice? |
|
Definition
|
|
Term
which hormone increases seizure effect
why? |
|
Definition
|
|
Term
| which hormone is seizure protective |
|
Definition
| progesterone (increases GABA) |
|
|
Term
| why do seizures occur rihgt before/during menstration? |
|
Definition
| bc estrogen >>> progesterone |
|
|
Term
| AEDs that are hepatic inducers do what-2 |
|
Definition
increase steroid hormone
decrease fee sex hormones |
|
|
Term
| AEDs that decrease oral contraceptives-4 |
|
Definition
all classicla but valproate
topiramate, oxacarbamezapine, lamotrigine, |
|
|
Term
| valproate is associ with what disease |
|
Definition
|
|
Term
| during pregnancy what happens to seizures |
|
Definition
| 1/3 increase but 1/3 decrease |
|
|
Term
| what 2 drugs cause cleft palate and heart malform if used in preggos |
|
Definition
|
|
Term
| what 2 drugs cauase spina bifida if sued in preggos |
|
Definition
| valproate and carbamezapine |
|
|
Term
| many birth defects can be prevented by supplementaiton of |
|
Definition
|
|
Term
| if using 1st gen AEDS, to reduce hemmorhage need to give in last month |
|
Definition
|
|
Term
| *higher protein binding = less in breast milk |
|
Definition
|
|
Term
status epilepticus is when seizure lasts?
what else cna be defined as it? |
|
Definition
30 minutes
reccurrent seizures without period of conciousness |
|
|
Term
| what is the more common SE? |
|
Definition
| generalized convulsive (almost msot severe) |
|
|
Term
| incidence of generalized SE is higher for what ages |
|
Definition
|
|
Term
| nonconvulsive SE has what continuous state |
|
Definition
| twilight/altered conciousness |
|
|
Term
drug of choice for SE
why? |
|
Definition
lorazepam (is IV)
higher affinity for BDZ recpt than diazepam |
|
|
Term
for the SE drugs which gets to brain first?
which stays longer tho? |
|
Definition
|
|
Term
| second line treatment for SE |
|
Definition
phenytoin
fosphenytoin (will have less phlebitis)and cna infuse faster |
|
|
Term
|
Definition
|
|
