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Exam 3
Lecture 1
43
Architecture
8th Grade
05/03/2013

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Term
hemodynamic stress can cause what type of heart failure?
-what specific things can cause this stress?
Definition
acute;
fluid overload, large MI, valve dysfunction
Term
what can cause chronic heart failure (general things)-4
Definition
ischemia
idopathic
HTN
diabetes
Term
intrinsic cardiac regulation is done by what?
-what are the 2 mechansims for this
Definition
changes in blood flow into heart
frank starling & right atria stretch
Term
Regulation of heart rate and contraction strength is done by
Definition
autonomic nervous system
Term
the pathophys of HF involves cardiac impairment that activates what-
Definition
compensatory mechanisms
Term
this mechanism acts by volume dilating the heart and increases bridging of sarcomeres to increase contraction
Definition
frank starling
Term
ts mechanism is the collective changes that occur due to injury of the heart/work load?
what are 2 specific changes-
Definition
myocardium adaptions
hypertrophy & ventricluar remodeling
Term
what are the mechanisms involved in the pathophys of HF- 3
Definition
frank starling
myocardium adaptations
neurohormonal system activation
Term
activation of the nuero system includes:5
Definition
NE release
RAS
atrial/brain naturietic pepetides
prostoglandin
NO
Term
compensatory mechanisms start damaging the body: what are 3 things that cause damage
Definition
myocyte apoptosis
cytoskeleton alteration
ECM deposit/fibrosis
Term
what increases in size in myocardium hypertrophy?
what is this dependent on?
so what does this cause an increase of?
Definition
myocyte
protein synthesis
nuclei
Term
if on autopsy the person has an enlarged heart and its walls are thick- what type of hypertrophy is it?
Definition
pressure overload
Term
in which type of hypertrophy are the new sarcomeres parallel to the old
Definition
pressure overload
Term
if a person has myocardium hypertrophy and the ventricles are dilated- what type is it?
Definition
volume overloaded
Term
myocardial infarction causes what type of overload on the heart
Definition
volume
Term
valve disease can cause what type of overload on the heart
Definition
volume or pressure
Term
HTN can cause what type of overload on the heart
Definition
pressure
Term
what a physiologic hypertrohpy of the heart?
how is this increase in size different?
Definition
aerobic exercise (volume-load)
causes the capillary density
Term
baroreceptor dysfunction goes and activates what neurohormone systems?
which of these activates the RAS?
Definition
sympathetic
vasopressin
sympathetic system
Term
whcih compensatory mechanism causes decreased limb blood flow and increases renal blood flow?
Definition
sympathetic
Term
if the patient has HF with an EF that is below 40, what type is it?
Definition
systolic
Term
if the patient has HF and the EF is sustained what type is it?
Definition
diastolic
Term
which type of heart failure is more common in:
women
>65 yo
Definition
diastolic
Term
backward failure is defined as
Definition
congestion in venous system
Term
forward failure is defined as
Definition
decreased Cardiac output/ perfusion
Term
causes of chronic left side heart failure-4
Definition
ischemia
HTN
myocardial disease
valve disease
Term
HF with left ventricular hypertrophy is what side?
Definition
left sided
Term
when the left ATRIUM is dilated from left sided HF what are the risks-2
Definition
A fib
thrombosis
Term
heavy, wet lungs is a sign of what type of heart failure
Definition
left sided
Term
HF with pulmonary edema is what side?
Definition
left
Term
which type of heart failure has the heart failure cells?
what are these cells?
what are they a telltale sign of?
Definition
left sided
hemosiderin macrophages
pulmonary edema
Term
What are causes of right sided heart failure?-3
Definition
left sided
cor pulmonale
pulmonary HTN/edema
Term
one of the most common signs of right sided heart failure is-
Definition
pulmonary hypertension
Term
ednocardium fibrosis/carcinoid heart disease is a sign of what sided heart failure
Definition
right
Term
what side HF affects the portal/hepatic systems?
what are signs?-3
Definition
right sided
hepatomegaly
spenomegaly
ascites
Term
perripheral edema is a sign of what sided HF
Definition
right
Term
these are symptoms of what side HF:
dyspnea
fatigue
Definition
Term
dyspnea in the recumbent position is known as-
it is a sign of what heart failure
Definition
orthopnea
left sided
Term
nocturnal dyspnea is most common in what heart condiiton
what does it increase risk for?
Definition
A fib
thombosis
Term
jugular venous distension is a sign for what sided heart failure
Definition
right
Term
this condition is caused by decreased sensistivity to PCO2
Definition
cheyne-stokes respiration
Term
cardiogenic shock or cardiogenic pulmonary edema are caused by what-2
Definition
severe left ventricular dysfunction-> pulmonary congestion
or
systemic hypoperfusion
Term
hypopoerfusion from shock.cardiac edema is when Cardiac index is below
and ssytolic BP is below _ despite pulmonary pressure above_?
Definition
2.2
90
18
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