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Exam 3
tons
98
Pharmacology
Graduate
04/08/2013

Additional Pharmacology Flashcards

 


 

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Term
Ticlodipine
Definition
Anti platelet
Term
Clopidogrel
Definition
Irreversable Platelet Inhibitor (ADP Rec. Blocker)
CYP2c19 Testing (asians)
Term
Prasugrel
Definition
Anti platelet
more bleeding than clopidogrel
Term
Ticagrelor
Definition
Reversible* Antiplatelet
ADR-dyspnea, uric acid
Term
Abciximab
Definition
IIb/IIIa receptor antagonist
Term
Eptifibatide
Definition
IIb/IIIa receptor antagonist
stents
Term
Triofiban
Definition
IIb/IIIa receptor antagonist
Term
Dipyridamole
Definition
Direct coronary vasodilator (antiplatelet)
Oral:TIA/CVA reduction
IV: CAD diagnostic (stress test)
*Severe HA
Term
Warfarin
Definition
Coumarin Anti Coagulant
Term
UFH
Definition
Indirect Thrombin Inhibitor
5000 SQ q8 for DVT proph
Renal dysfunction
thrombus may still grow
Term
Rivaroxaban
Definition
Factor Xa inhibitor
Non Valvular AF
6-10h AFTER surgery, CrCl>30
Term
Apixaban
Definition
Factor Xa inhibitor
Non valvular AF
Term
Enoxaparin
Definition
LMWH SQ
Better for treatment
Term
Dalteparin
Definition
LMWH
Term
Fondaparinux
Definition
LMWH
Term
Dabigatran
Definition
Direct Thrombin INhibitor
Keep tightly capped, no pillboxes
ADR-Dyspepsia/Gastritis, >GI bleed
Term
Argatroban
Definition
Direct Thrombin Inhibitor
*Give for HITTS
Term
Desirudin
Definition
Direct Thrombin INhibitor
Term
Bivalirudin
Definition
Direct Thrombin Inhibitor
Term
Alteplase
Definition
Fibrinolytic TPA
For Stemi, PE, Stroke, CVL clearance
Term
Reteplase
Definition
Fibrinolytic RPA
STEMI
Term
Teneteplase
Definition
Fibrinolytic TPA
Term
Colchicine
Definition
For Acute Gout Flares (3rd Line)
Strong 3A4 inhibitor (clarithro) and Pg Inhibitor (cyclosporine)
**DIarrhea
Term
Allopurinol
Definition
Gout-Xanthine Oxidase Inhibitor
*Paradoxical Flare, Rash->SJS
*Allopurinol Hypersensitivity Syndrome-F/Hep/ARF/Eosinophilia
Term
Febuxostat
Definition
Gout- Xanthine Oxidase Inhibitor
Term
Probenacid
Definition
Gout- Urate Excretor
Need CrCl >50
ADR - *Acute Flare, UA stones
Term
Pegloticase
Definition
Gout- Urate Excretor
Last Line chronic
*Tophi Debulker
ADR- Severe gout Flare
Term
Methotrexate
Definition
Non-Biologic DMARD
Hold for sick in hospital, supplement folate
*Abortion Drug!
ADR- Pulmonary and Liver fibrosis
Term
Leflunomide
Definition
Non Biologic DMARD
2nd line to MTX
*Teratogen-D/C and take Cholestyramine for wanted Preg.
ADR- *Bad Diarrhea
Term
Hydroxychloroquine
Definition
Non Biologic DMARD
*Need Ophtho Exams
*Dont give to g6pd
Term
Sulfasalazine
Definition
Non Biologic DMARD
*Sulfa Rash
*Hemolysis in g6pd
Term
Eternecept
Definition
Biologic DMARD - TNF Inhibitor
qwk
Term
"MAB drugs"
Definition
Biologic DMARDS- TNF inhibitor
mod-severe arthritis
Term
Azothioprine
Definition
Anti-Metabolite Transplant
*Problematic w/ Allopurinol and ACE
ADR-Myelosuppression
Can use for RA/Vasculitis
Term
Mycophenolate
Definition
Anti-Metabolite Transplant
ADR- *Myelosuppression, **Black Label Teratogen**
Off label GVHD
Term
Cyclosporine
Definition
Calcineurin Inhibitor Transplant
Monitor Troughs, Macrolides knock this out (3A4)
ADR- *Nephrotoxic, *DM, *Gingival Hyperplasia, HTN
Can use for RA
Term
Tacrolimus
Definition
Calcineurin Inhibitor Transplant
ADR *PTDM, HTN
can use for atopic dermatitis
Term
Prednisone
Definition
Corticosteroid for Transplant
*Proximal Myopathies with high dose
Term
Sirolimus
Definition
MTOR Inhibitor Transplant
Term
Rapamycin
Definition
MTOR inhibitor transplant
Term
Beletacept
Definition
New Transplant drug
ebv
Term
Quinidine
Definition
Class 1a Antiarhythmic
*Syncope
*Cinchonism
Term
Procainamide
Definition
Class 1a Antiarrhythmic
*Reversible Lupus rxn
Term
Disopyramide
Definition
Class 1a Antiarrhythmic
*Glaucoma
*BPH
Term
Lidocaine
Definition
Class 1b Antiarrhythmic
*CNS toxicity- tremor, seizure
Term
Mexilitine
Definition
Class 1b Antiarrhythmic
*CNS Toxicity- Dizzy/lightheaded
Term
Flecainide
Definition
Class 1c Antiarrhythmic (Need ECHO!)
*For Proarrhythmias
**Black Box- Not for AMI pt!**
Term
Propafenone
Definition
Class 1c Antiarrhythmic (Need ECHO!)
Dysguesia- altered taste
lupus like rxn
Term
Sotolol
Definition
Class III antiarrhythmic
*Racemic Mix
Avoid B-blockers and CCBs
Term
Dofetilide
Definition
Class III antiarrhythmic
*Restricted Distribution-> Hospital and 3d obs
Term
Ibulitide
Definition
Class III antiarrhythmic
Term
Amioderone
Definition
Class III antiarrhythmic
for VF, VT, cardioversion, AF proph
*Increases Dig Toxicity
ADR- fibrosis, thyroid, occular, blu/gray skin, cardiac tox
Term
Dronederone
Definition
Class III antiarrhythmic
Non Iodinated analogue of amioderone
*Increase INR with Warfarin
Dont use in CHF, AV block, SSS, or Brady--> AF
Term
Digoxin
Definition
Antirrhthmic
Use in HF pt
*Measure Serum Troughs (.5-.8 for HF)
Dig Toxicity! dont decrease K or Mg
Term
Mannitol
Definition
Diuretic-Proximal tubule and Loop of Henle
*Decrease ICP, GU irrigant for Turp
*Kidney dumps free water!
Term
Acetazolamide
Definition
Diuretic-Block Nacl and HCO3 resorption at renal tubule (CAI)
*Acute Mountain Sickness
*Metabolic Alkylosis
Term
Furosemide
Definition
Loop Diuretic
Interax- NSAIDS (retain Na), DM meds
ADR- Hypokalemia/mag, Hyperglycemia
Term
Toresimide
Definition
Loop Diuretic
Term
Bumetanide
Definition
Loop Diuretic
Term
Ethacrynic Acid
Definition
Loop Diuretic
*No Sulfa Group
**Ototoxicity
Term
HCTZ
Definition
Thiazide- Distal Convoluted Tubule
*Increase Ca reabsorption, decrease kidney stone
Term
Chlorthalidone
Definition
Thiazide- Distal convoluted tubule
Term
Metalazone
Definition
Thiazide-distal convoluted tubule
Good when CrCl<30
Use c Loop for synergy
Term
Indapamide
Definition
Thiazide
Term
Chlorothiazide
Definition
IV THiazide diuretic
Term
Spironolactone
Definition
K sparing diuretic (anti aldosterone)
*Teratogen
MR receptor blocker
Term
Eplerenone
Definition
K sparing diuretic
MR receptor blocker
Term
Amiloride
Definition
K sparing Diuretic
Distal dubule
Term
Triamterene
Definition
K sparing diuretic
*Nephrotoxicity and Stones!
Term
Lisinopril
Definition
ACEI
Use HTN c LVH, *AMI/HF c Systolic dysfn, CKD
ADR-*Cough, *Teratogen, *Hyperkalemia, *Angioedema in blacks
Term
Enalapril
Definition
ACEI
Same as lisinopril
Term
Losartan, Valsartan
Definition
ARB- Block angiotensin II to AT1 receptors
Term
Aliskerin
Definition
Renin Inhibitor
*P-gp inhibitors may increase concentration
Term
Prazosin, Terazosin, Doxazoisin
Definition
A-Blockers- Arterial Vasodiators
HTN and BPH
Do Not use with NITRATES, decongstants
ADR- *FLoppy IRIS, Postural Hypotension
Term
Propranolol, Nadolol, Timulol
Definition
B-Blockers, Non selective
watch for bronchospasm, raynauds
Term
Metoprolol
Definition
B Blocker- Selective
*SSRI inhibit 2D6
Term
Carvedilol
Definition
a and B blocker
2C9 and 2D6
* Floppy Iris
Term
Labetalol
Definition
a and B blocker
IV
Floppy Iris
Term
Amlodipine
Definition
CCB dihydropyridine
Peripheral Vasodilator for HTN, Angina, Raynauds
ADR- *Edema, Reflex Tach, *Gingival Hyperplasia
Term
Verapamil
Definition
CCB- Nondihydro.. Decrease cardiac contractility
Use SVT, AF... NOT CHF
*Constipator
Careful with B blockers and Dig
Term
Diltiazem
Definition
CCB - Nondyhydro.. decrease cardiac contractility
*Constipation
Use SVT, AF.. not CHF
careful with b blockers and dig
Term
Clonidine
Definition
Central a2 agonist
Decrease PVR, HR, BP
*HTN CRISIS with abrupt withdrawl
Term
Methyldopa
Definition
Central A2 agonist
Decrease PVR, HR, BP
*For pregnant
*Lactation, +coombs, sedation
Term
Hydralazine
Definition
Direct Vasodilator-Relax art SM=decrease PVR
Use-HTN urgency, HF (Bidil), Preeclampsia
ADR- Lupus like rxn
Term
Minoxidil
Definition
Direct Vasodilator- Relax art SM= decrease PVR
Use- HTN, Alopeica (last line adjunct)
ADR- Fluid retention, reflex tach, hirsutism
Term
Rosuvastatin
Definition
Statin
less myalgias, better for liver dz
Term
Atorvastatin
Definition
Statin
Good for CKD
Term
Simvistatin
Definition
Statin
Take QHS
major 3A4 substrate, increased myalgias
Term
Pravastatin
Definition
statin
less myalgias, better for liver dz
Term
Lovastatin
Definition
Old statin
Term
Fluvastatin
Definition
Old Statin
Term
Ezetimibe
Definition
Cholesterol Absorption inhibitor
small intestine, decrease LDL
Term
Cholestyramine
Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance
Term
Colestipol
Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance
Term
Colesevelam
Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance
Term
Niacin
Definition
Target HDLs and TGs
**FLUSHING
*aggravate glucose and gout
start low go SLOW
Term
Gemfibrozil, Fenofibrate, fenofibric acid
Definition
Fibrate-TGs
*Myositis and Rhabdo possible
Term
Fish OIL
Definition
decrease TG synthesis and increase TG clearance
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