Term
T/F
Under Law of Mass Action we assume that binding is totally reversible |
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Definition
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Term
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Definition
| The [drug] at which binding is half maximal |
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Term
Which has a greater affinity?
Kd=25pM
Kd=3pM |
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Definition
Kd=3pM
it takes less drug to bind to the receptors |
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Term
| What gives receptors their shape? |
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Definition
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Term
T/F
a drug will always bind to its receptor |
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Definition
FALSE
it may bind to other membrane proteins |
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Term
Labeled and unlabeled drug determine_____
total binding
nonspecific binding
receptor binding |
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Definition
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Term
T/F
at a lower Kd, it takes a small [drug] to be 1/2 saturated |
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Definition
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Term
| When looking at a scatchard plot, if the graph has 2 paralell lines what does this mean in terms of the Kd and Bmax? |
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Definition
Paralell lines have the same slope which means their Kd are the same and they have the same affinity.
This tells you nothing about the Bmax (where it intersects the x-axis) |
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Term
[image]
What is the Bmax?
What does this number mean |
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Definition
Bmax~ 65
Maximum [bound ligand] |
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