Term
T/F
Drugs give us the ability to modulate and create new functions |
|
Definition
False
we can only modulate NOT create |
|
|
Term
| An immune cell is an example of ______ in that it secretes something which binds to its own receptor |
|
Definition
|
|
Term
| A cell that releases histamines is an example of ______ in that what it secretes binds to a receptor in the immediate vacinity |
|
Definition
|
|
Term
| Endocrine cells require its secretory portions to be ____ |
|
Definition
|
|
Term
| _____is an example of how platelets aggregate together. (One cell has a tethered ligand) |
|
Definition
| Cell to Cell communication |
|
|
Term
Which type of signal would generate a fast response?
a) endocrine
b)paracrine
c) synapse
d)autocrine |
|
Definition
Paracrine
short loop synapses
autocrine |
|
|
Term
| Transduction is signaling from _____to_____ |
|
Definition
| outside the cell to inside the cell |
|
|
Term
| What characteristics must a molecule have to be a ligand for an intracellular receptor? |
|
Definition
|
|
Term
| How do hydrophilic molecules get their signals inside the cell? |
|
Definition
| through surface cell receptors |
|
|
Term
___ receptors can detach and transport molecules
___ receptors move partially through the membrane
___receptors may act as 2nd messengers |
|
Definition
Peripheral
Integral
Transmembrane
See pg 6 |
|
|
Term
T/F
Drugs that are similar in structure may bind to receptors |
|
Definition
|
|
Term
T/F
Antagonist occupy the receptor and decreases its response |
|
Definition
|
|
Term
T/F
There are drugs that can bind to many different receptors |
|
Definition
TRUE
ex Dopamine and Norepi |
|
|
Term
T/F
all drugs that have therapuetic activity must bind |
|
Definition
TRUE
they must bind but not necessarily give a response |
|
|
Term
[image]
Which has the greatest affinity? |
|
Definition
The first line (-8)
(it takes the smallest [agonist] to give a response) |
|
|
Term
[image]
Which line is the partial agonist? |
|
Definition
The second line (-7)
It does not give a maximum response aka doesnt reach 100% |
|
|
Term
[image]
What would an antagonist look like on this graph? |
|
Definition
| A straight horizontal line at 0 meaning no response |
|
|
Term
[image]
Which line is the full agonist? |
|
Definition
The 1st (-8) and 3rd (-5) lines
(they reach maximum response) |
|
|
Term
A partial agonist has____affinity and ____intrinsic activity
|
|
Definition
Full affinity and partial intrsinsic activity
(will bind to receptor bu intiate <100% response) |
|
|
Term
| An Antagonist has___affinity and ___intrinsic activity |
|
Definition
full affinity and NO intrinsic activity
(will bind but no response) |
|
|
Term
Explain Inverse Agonism in terms of the ligangs
(Clue: Basal activity) |
|
Definition
When no ligand is bound there is basal activity
when an INVERSE AGONIST binds there is <basal activity
When a FULL AGONIST binds the response is >basal activity |
|
|
Term
T/F
alpha 2 receptors can exhibit inverse agonism |
|
Definition
TRUE
there is always some degree of contraction in our blood vessels (basal activity). We have ligands that can decrease or increase this contraction once bound |
|
|
Term
α or β
Increases force of contraction of heart
Constricts blood vessels
Dilates blood vessels
Increase Rate of contraction of heart |
|
Definition
Increases force of contraction of heart-β
Constricts blood vessels-α
Dilates blood vessels-α
Increase Rate of contraction of heart-β |
|
|
Term
What is the result?
Administer Phenylephrine (α agonist) |
|
Definition
|
|
Term
What is the result?
Administer Epinephrine (α and β agonist) |
|
Definition
| Increased BP and Inc rate and force of contraction |
|
|
Term
What is the result?
Administer Isoproterenol (β agonist) |
|
Definition
| Increase force of contraction and rate |
|
|
Term
What is the effect?
Administer Phentolamine (α antagonist) |
|
Definition
No effect on its own so will see relatively no change in BP
It only PREVENTS agonist activity |
|
|
Term
What is the result?
Epi (α & β agonist) first then Propanolol (β antagonist) |
|
Definition
Increased BP, force and rate of contraction
(antagonist will only work is it is administered first) |
|
|
