Term
| What age group is more likely to have drug-drug interactions? |
|
Definition
| elderly and hospitalied patients |
|
|
Term
T/F
Drug-drug interactions are bad and must be avoided at all costs |
|
Definition
FALSE
some may have therapeutic benefit |
|
|
Term
Why can't tetracyclines and antacids be admistered at the same time?
DETAILS |
|
Definition
They form insoluble complexes in the intestines. The metal causes the interaction.
These complexes result in decreased absorption of both drugs |
|
|
Term
| Inhibition of Pgp in the gut will result in____ |
|
Definition
|
|
Term
| inhibition of Pept1 results in____ |
|
Definition
|
|
Term
| Competitive displacemet from binding sites on proteins will result in ____distribution of drugs like warfarin |
|
Definition
Increased
(warfarin is highly protein bound. If a drug displaces the warfarin on its binding site you will get more free drug ad more distribution) |
|
|
Term
|
Definition
|
|
Term
| Explain the process of indcution via nuclear receptors |
|
Definition
1) inducer binds to receptor (CAR/PXR)
2) CAR/PXR enters the nucleus and forms a heterodimer with RXR
3) the heterodimer binds to the promoter gene on DNA
4) get gene transcription and increased expression of enzymes |
|
|
Term
| What happens to an oral contraceptive that is a substrate for CYP3A4 (metabolized into inactive form) if rifampin is taken with it and is an inducer fo CYP3A4? |
|
Definition
| get decreased levels of active contraceptive (increase lvls of the inactive form) |
|
|
Term
T/F
Drug-Drug interactions only occur during the Metabolism portion of ADME |
|
Definition
FALSE
they may occur in each part |
|
|
