Term
| α-Methyldopa - Alpha-two receptor Agonists - leads to inactivation of of NE |
|
Definition
| (Aldomet) (false transmitter) |
|
|
Term
Clonidine - Alpha-two receptor Agonists
stops release of NE when bind to A2 |
|
Definition
|
|
Term
Tolterodine - Overactive Bladder
block M3 receptors
relax the detrussor muscle and constrict the trigone sphincter |
|
Definition
|
|
Term
Oxybutynin - Overactive Bladder
block M3 receptors
relax the detrussor muscle and constrict the trigone sphincter |
|
Definition
|
|
Term
Darifenacin - Overactive Bladder
block M3 receptors
relax the detrussor muscle and constrict the trigone sphincter |
|
Definition
|
|
Term
Solifenacin - Overactive Bladder
block M3 receptors
relax the detrussor muscle and constrict the trigone sphincter |
|
Definition
|
|
Term
Aliskiren - Direct Renin Inhibitor
treatment of hypertension - not CHF
TERATOGENIC, angioedema |
|
Definition
|
|
Term
Hydralazine
vasodilation- NO SNS effects
LUPUS - like symptoms |
|
Definition
|
|
Term
Sodium nitroprusside
potent vasodilation; given IV bc of short onset of duration
doesn't require endothelium to convert to NO
light breaks it down |
|
Definition
|
|
Term
Fenoldopam- DA 1 selective agonist
dilation of BV
SX: hypoTN, reflex tachy, HA, flushing & N |
|
Definition
|
|
Term
Minoxidil
potent vasodilation
causes high h2o retention (pt will need to take BB + loop)
possible peri<3 effusion |
|
Definition
|
|
Term
Diazoxide
vasodilation - similar structure to thiazide
ON on BV |
|
Definition
|
|
Term
Epoprostenol - Prostaglandin Analogs
rapidly hydrolyzed at neutral pH in blood and is also subject to enzymatic degradation --> IV |
|
Definition
|
|
Term
Iloprost - Prostaglandin Analogs
6-9 QD
Inhalation |
|
Definition
|
|
Term
Treprostinil - Prostaglandin Analogs
rapidly and completely absorbed during continuous subcutaneous infusion. It is metabolized by the liver |
|
Definition
|
|
Term
Terbutaline
beta2 adrenergic agonist |
|
Definition
|
|
Term
Albuterol
beta2 adrenergic agonist |
|
Definition
|
|
Term
Salmeterol
beta2 adrenergic agonist |
|
Definition
|
|
Term
Ritodrine
beta2 adrenergic agonist |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
alpha-methytyrosine / metyrosine
adrenergic antagonist
for pheochromocytoma (not HTN)
interferes with synthesis of catecholamines |
|
Definition
|
|
Term
α-Methyldopa
alpha1 adrenergic antagonist
for HTN
interferes with synthesis of catecholamines |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
a. Amphetamine
b. Tyramine
c. Cocaine
d. MAOIs |
|
|
Term
|
Definition
| α1, α2, β1, β2 plus some indirect |
|
|
Term
Dopamine
adrenergic agonist
D1 > beta1 > alpha1
(vasodilation > +chronotropy, inotropy > vasoconstriction) |
|
Definition
| (Intropin) D1, β1, α1 plus some indirect |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Prazosin - Alpha Receptor Blocking Agents -- Selective -blood pressure
Dilate vessels, decrease venous return and cardiac output |
|
Definition
|
|
Term
Terazosin - Alpha Receptor Blocking Agents -
Selective
Dilate vessels, decrease venous return and cardiac output |
|
Definition
|
|
Term
Doxazosin - Alpha Receptor Blocking Agents
Selective
Dilate vessels, decrease venous return and cardiac output |
|
Definition
|
|
Term
| Tamsulosin - Alpha Receptor Blocking Agents - - Selective BPH |
|
Definition
|
|
Term
Alfuzosin - Alpha Receptor Blocking Agents
Selective
Alpha 1 A |
|
Definition
|
|
Term
Silodosin - Alpha Receptor Blocking Agents
Selective |
|
Definition
|
|
Term
Sildenafil - PAH
improve exercise ability and delay clinical worsening
inhibitor of PDE5 - increases cGMP - dilation/ relaxation
don't take with nitrates |
|
Definition
|
|
Term
Tadalafil - PAH
improve exercise ability and delay clinical worsening
inhibitor of PDE5 - increases cGMP - dilation/ relaxation
don't take with nitrates or alpha blockers or nitrates or other HTN meds |
|
Definition
|
|
Term
Quinidine - NaCB Ia
proarrhythmic- concerns with torsades, could double dig lvl & increase coumadin activities (dec K Factors)
Block nicotinc receptor in skeletal muscle – myasthenia-like symptoms |
|
Definition
| Quinora, Quinidex, Cardioquin |
|
|
Term
Procainamide - NaCB Ia
not as much antivagal effects, some lupus like syndrome |
|
Definition
|
|
Term
Disopyramide - NaCB Ia
no alpha blocking (possible peri constriction/resistance)
most anti-vagal & neg inotrophic activity
anticholingeric effects!!!!sea |
|
Definition
|
|
Term
Lidocaine - NaCB Ib
extensive first pass- IV
minimal adverse effects, some CNS (DROWSINESS) , no heart |
|
Definition
|
|
Term
|
Definition
|
|
Term
Flecainide - NaCB Ic
sig neg inotropic effects - slow vent & AV conduction
inc 15% dig levels |
|
Definition
|
|
Term
Propafenone - NaCB Ic
has BB & CCB effects |
|
Definition
|
|
Term
|
Definition
| (not used for arrhythmias but compared to quinidine) |
|
|
Term
Propranolol - BB II reduces mortality
NS, MSA |
|
Definition
|
|
Term
Acebutolol - BB II reduces mortality
B1, MSA, ISA |
|
Definition
|
|
Term
Esmolol - BB II reduces mortality
B1, ISA
t 1/2 9 mins- rapidly metabolized by RBC esterase- IV for PSVT |
|
Definition
|
|
Term
Amiodarone - Prolong APD III
lots of effects- blocks, K, Na, C, beta & alpha
t1/2- 30-60 days, no torsades, causes AIPT- pulm fibrosis
inc dig & coumadin levels |
|
Definition
|
|
Term
Dronedarone - Prolong APD III
new non-iodinated compound
shorter t1/2, less soluble, thyroid effects & pulm fibrosis |
|
Definition
|
|
Term
Sotalol - Prolong APD III
oldest drug & BB
block K channels, prolong QT, NS BB abilities |
|
Definition
|
|
Term
Ibutilide - Prolong APD III - pure
open slow Na @ early phase 3- prolong QT |
|
Definition
|
|
Term
Dofetilide - Prolong APD III - pure
blocks I_kr (rapid outward rectifying K)
no effect on PR/QRS
proarrhythmic drug- dangerous |
|
Definition
|
|
Term
Verapamil - CCB IV
for SVA |
|
Definition
|
|
Term
Adenosine - antiarrhythmia agent
Effects on A1 (<3 tissue) & 2 (endothelium on BV)
effects similar to ACH, t1/2 1.5 sec, injected |
|
Definition
|
|
Term
| Atropine - antiarrhythmia agent |
|
Definition
|
|
Term
| Guanfacine - Alpha-two receptor Agonists |
|
Definition
|
|
Term
| Guanabenz - Alpha-two receptor Agonists |
|
Definition
|
|
Term
Finasteride
BPH- 5-alpha reductase inhibitors |
|
Definition
|
|
Term
Dutasteride
BPH- 5-alpha reductase inhibitors |
|
Definition
|
|
Term
| Trospium - Overactive Bladder |
|
Definition
|
|
Term
| Fesoterodine - Overactive Bladder |
|
Definition
|
|
Term
| Flavoxate - Overactive Bladder |
|
Definition
|
|
Term
Trimethaphan camsylate
vasodilation |
|
Definition
|
|
Term
| Nesiritide - Atrial natriuretic agonist |
|
Definition
|
|
Term
| Right ventricular failure, peripheral edema, ascites, hepatic congestion - PAH supporting |
|
Definition
| Loop diuretics, Metolazone (Zaroxolyn), Potassium-sparing Agent |
|
|
Term
| Inotropic agent to support heart failure - supporting PAH treatment |
|
Definition
|
|
Term
Chronic pulmonary thromboembolism
- supporting PAH treatment |
|
Definition
|
|
Term
Vascular-targeted treatment directed at reversing or decreasing vasoconstriction, vascular endothelial cell proliferation and smooth muscle cell proliferation
- supporting PAH treatment |
|
Definition
Prostaglandin Analogs
Endothelin Receptor Antagonists
PDE-5 Inhibitors |
|
|
Term
Bosentan - PAH
first oral endothelin receptor antagonist |
|
Definition
|
|
Term
Ambrisentan - ETA receptor antagonist
High affinity |
|
Definition
|
|
Term
Tocainide - NaCB Ib
oral agent |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Digoxin - antiarrhythmia agent |
|
Definition
|
|
Term
Phentolamine - Non-selective alpha blocker
vasodilation |
|
Definition
| Vasomax , Regitine , Z-Max |
|
|
Term
| what are lupus like symptoms |
|
Definition
| arthralgia, pericarditis, pulmonary complications and hepatomegaly |
|
|
Term
|
Definition
| glaucoma, constipation, dry mouth/eyes, urinary retention & blurred vision. |
|
|
Term
|
Definition
Moderate Na blockade
inc APD bc of K blockade - prolong QT |
|
|
Term
|
Definition
Weak Na blockade
dec APD bc of inc K permeability |
|
|
Term
|
Definition
Strong Na blockade - depresses phase 0
no effect on K blockade/permeability (normal APD) |
|
|
