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Exam 3 Biochem-Lecture 28
From Lecture Notes
29
Chemistry
Professional
11/05/2009

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Term

 

Desaturation of Fatty Acids requires combination of

Definition
  • desaturase enzyme
  • cytochrome b5
  • NADPH-cytochrome b5 reductase
Term
Triacylglycerols are synthesized from:
Definition
  • Fatty Acyl CoAs
  • Glycerol 3-Phosphate
Term

 

The first step  of Synthesis of Triacylglycerols is formation of  ......?
Definition

phosphatidic  acid.

Term
Fatty acyl CoAs are formed ....?
Definition
outside mitochondria
Term
What is the transport molecule for fatty acids into the mitochondrial matrix???
Definition
Carnitine
Term

 

FAS are oxidized sequentially how many carbons at a time???
Definition

 

FAS are oxidized sequentially 2 carbons at a time.
Term

Sequential steps of  Fatty Acid b-Oxidation are:

Definition

 

  1. Dehydrogenation
  2. Hydration
  3. Oxidation
  4. Cleavage
Term

 

Fatty Acid b-Oxidation is Oxidized while attached as:

Definition

 

as a thioester to 4-phosphopantetheine of CoA
Term

Overall yield of  Fatty Acid b-Oxidation is

Definition

 

106 ATPS.

Term

 

b-oxidation oxidizes saturated fatty acids with even or odd number???
Definition

 

b-oxidation oxidizes saturated fatty acids with even number
Term
In Fatty Acid Oxidation, Odd-chains produces
Definition
propinolyl CoA
Term

 

•In Fatty acid Oxidation, Unsaturated fatty acids require ....?
Definition
additional enzymes
Term
In Fatty Acid Oxidation, a- oxidation is necessary for
Definition
  • for metabolism  of branched chain fatty acid
  • uses fatty acid a hydroxylase
  • occurs in peroxisomes
Term
Ketone Bodies
Definition
  • an alternate fuel for cells
  • Water soluble lipid based energy
Term
Ketone Bodies formation occurs
Definition
 in the mitochondrial matrix
Term
 b-hydroxy-b-methylglutaryl CoA (HMG-CoA) is intermediate in
Definition
 b-hydroxy-b-methylglutaryl CoA (HMG-CoA) is intermediate in acetoacetate synthesis from acetyl-CoA.
Term

In Ketone Body synthesis, 

2 acetyl-CoA molecules are condensed

to form ...............by b-ketothiolase.

Definition

In Ketone Body synthesis,   

2 acetyl-CoA molecules are condensed

to form acetoacetyl-CoA by b-ketothiolase.

Term

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by what????

Definition

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

Term

In Ketone Bodies synthesis, what is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase???

Definition

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

Term

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with what to form HMG-CoA by HMG-CoA synthase.???

Definition

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

Term

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form what by HMG-CoA synthase???

Definition

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

Term

 

HMG-CoA is cleaved by HMG-CoA lyase

to yield

Definition
  • acetoacetic acid 
  •  acetyl-CoA.
Term

 

Acetoacetic acid is reduced to d-b-hydroxy-

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of how many NADH??.

Definition

 

Acetoacetic acid is reduced to d-b-hydroxy-

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

Term

 

What is reduced to d-b-hydroxy-

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH???

Definition

 

Acetoacetic acid is reduced to d-b-hydroxy-

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

Term

 

Acetoacetic acid is reduced to what by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH???
Definition

 

Acetoacetic acid is reduced to d-b-hydroxy-

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

Term

 

Acetoacetic acid spontaneously forms
Definition
  • acetone
  • + CO2.
Term

 

Absence of HMG-CoA lyase results in HMG-CoA being used for ???
Definition
cholesterol synthesis
Term
Ketone Bodies can be used by
Definition

Brain

Muscle

Other tissues

BUT NOT LIVER(Liver can not use ketone bodies)

 

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