Term
| tyrosine kinase transfer phosphate from _ to a trysoinse reside |
|
Definition
| ATP (why called phosphylation) |
|
|
Term
| tysonie kinases belong to a bigger class called |
|
Definition
|
|
Term
| phos/dephos is important fro signal trnasduciton leading to cancer |
|
Definition
|
|
Term
| 4 bad things that lead to too much tyrosine kinase activaiotn |
|
Definition
| genetic alteration, gene amp, point mutation, protein accum |
|
|
Term
what TKIs target BCR;ABL / CML
first line-1
second line -3 |
|
Definition
imatinib
nilotninb, dasatonib, bosutinib |
|
|
Term
|
Definition
|
|
Term
| CYP 3A$ inhibots that increase imatinib conc-4 |
|
Definition
| ketoconazole, itraocnazle, erthomycin, clarithromycin |
|
|
Term
| 3A4 induces that decrease imintib-4 |
|
Definition
| phenyotin, carbmezapine, st johns wort, dexmethasone |
|
|
Term
| counsel to take imatinib wiht-2 |
|
Definition
|
|
Term
| imatinib increases systemic conoc of- |
|
Definition
|
|
Term
| imatinib pts should recieve what type fo anticoag/ |
|
Definition
|
|
Term
| severe ADEs fo imitiniab-4 |
|
Definition
| hemorrhage, heptox, heme tox, CHF |
|
|
Term
| when is nioltinib considered for CML |
|
Definition
| chronic or accel phases that failed imatinib |
|
|
Term
| what tests follow effiacy of nilotinib-2 |
|
Definition
|
|
Term
| contraindicaiton for using nilotimib-3 |
|
Definition
|
|
Term
| 5 major drugs that have ineraction (3A4 inhibt) wiht nilotinib |
|
Definition
| amiodarone, dispoyramide, procainaimide, quindine, sotol |
|
|
Term
| pt wiht hisotry of _ dont use nilotinib |
|
Definition
|
|
Term
| indicaiton for dasatinib-2 |
|
Definition
chronic, aceel, blast pahse CML after imaitnib tx
ALL resistant to imtinib |
|
|
Term
| what are the 4 drug classes dasintib cant be used with- |
|
Definition
PPI/H2 anatg
antacids
3a4 inhib
3a4 inducers |
|
|
Term
| TKIs that target EGFR/HER-2 |
|
Definition
|
|
Term
| indications for erlotinib-2 |
|
Definition
non small cell lung (after fail chemo)
pancreatic |
|
|
Term
| erlotinib for pancreatic cancer needs to be combo with _ to be 1st line |
|
Definition
|
|
Term
| cig smoking decrease conc of what drug |
|
Definition
|
|
Term
| whcih drug has liver failr ADE |
|
Definition
|
|
Term
| which drug has abnormal eyelash growth |
|
Definition
|
|
Term
| whcih drug inhibits both HER-2 nad EGFR |
|
Definition
|
|
Term
| Lapatinib should be given once daily for _ dyas, and capecitabine BID for _ days. cycle is _ days |
|
Definition
|
|
Term
| common ADEs fo laptinib-2 |
|
Definition
|
|
Term
| severe ADEs fo laptinib-3 |
|
Definition
cardaic
heptox
intersti lung/pmneu |
|
|
Term
| TKIs that inhbit mult tyrosine kinases-3 |
|
Definition
sunitinib
sorafenib
pazopanib |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| counseling point for sorfenib |
|
Definition
|
|
Term
| indicaitons for sorefanib-2 |
|
Definition
RENAL carcinoma
hepat cell |
|
|
Term
| even tho has a lot fo interacitons with drugs, wiht most anti neoplastics sorafenib works well |
|
Definition
|
|
Term
|
Definition
hand foot
alopecia
wound healing |
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|
