Term
| types of etiology for AML-6 |
|
Definition
radiation
benzene
MDS
smoking cigarettes |
|
|
Term
| smoking ciagreets is espeically linked to what AML? |
|
Definition
|
|
Term
| median age for acute leukemias |
|
Definition
|
|
Term
| more males or females for acute leukemia? |
|
Definition
|
|
Term
| hgih/low death rate and new aceses per year? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| * AML cytogenics talked about have low death rate in remission, but high rate of remission at 5 yrs |
|
Definition
|
|
Term
| ask someonone about slides 8-11!! |
|
Definition
|
|
Term
|
Definition
anemia (pallor, weaknesS)
thrombocytopneia (brusing)
neutropenia (infection
anorexia |
|
|
Term
| some diagnostic work ups of AML-3 |
|
Definition
physical
CBC
bone marrow biopsy |
|
|
Term
| WHO classificaiton of AML |
|
Definition
| >20% blasts in the blood/marrow |
|
|
Term
| what are the cytogenic abnormalites that have AML regardles of blast % in blood-3 |
|
Definition
|
|
Term
How long do you wait for tx of AML?
what age is a no go? |
|
Definition
ASAP
no age contraindication |
|
|
Term
for CR during tx of AML goals:
ANC-
Plt
BM
what dont you want? |
|
Definition
>1500
>100,000
5% blasts
auer rods |
|
|
Term
waht is teh 2 part tx sereis for AML?
what do they mean? |
|
Definition
induciton, consolidaiton
inducotin- remission; consolidaiton- prevent recurrance |
|
|
Term
at what age are there inferiori outcomes for AML tx?
what might be areason? |
|
Definition
>60 yr
exponential increase in chromosomal abnormalites that cause acute leeukmia |
|
|
Term
| *perrformance staus of 3 with AML, means more chance of death |
|
Definition
|
|
Term
|
Definition
|
|
Term
| tx for AML pt over 60 with good cytogeneity |
|
Definition
|
|
Term
| tx for AML pt >60 and poor cytogeneity-2 |
|
Definition
|
|
Term
| tx for AML pt < 60 and good cytogeneity |
|
Definition
|
|
Term
| tx fr AML pt< 60 poor cytogeneity-2 |
|
Definition
|
|
Term
induciton tx for AML invovles what meds that are for 3 days (only pick one in the regiment)
+ what 7 day med
and |
|
Definition
daunorubicin, idarubiicn, mitoxantrone
cytarabine |
|
|
Term
what is the hgih dose daunorubicin
why is it used and who is it benefiical in? |
|
Definition
90mg/m2
better CR rates
<50 yo w/ favor/intermeiadte cytogeneity
(NCCN reccomedn only use in pts<60) |
|
|
Term
|
Definition
|
|
Term
| Chemo tx for consolidaoitn of AML invovles what med and dosing |
|
Definition
cytarabine 3mg IV q 12 hrs D1,3,5
(HiDAC) |
|
|
Term
chemo tx for consolidaiotn used mianly for pts of what age?
how mnay cycles? |
|
Definition
|
|
Term
allogeneic stem cell trnasplant is best for what age pts?
they should ahve what other 3 char |
|
Definition
<60
good perfomance status, HLA matched siblin, poor cytogeneics |
|
|
Term
| tx for pt >60 Ps 0-2 for induciton can be what 3 optinos |
|
Definition
3+7
clofarabine
low intesnity chemo |
|
|
Term
| tx for elederly pt for AML relpase that you DONT use |
|
Definition
|
|
Term
| complicaitns of AML tx:-4 |
|
Definition
tumor lysis
neutorpenia
GI
neuro |
|
|
Term
prophylaxis for neutropenia?
what age group is this ebst in |
|
Definition
filgrastim/sargramostim
>60 yo |
|
|
Term
| what prophylaxis for longer duraiont of neutorpenia w/ AML-3 |
|
Definition
|
|
Term
Char of APL pts:
old/young
typical present with
low what counts (2) |
|
Definition
young
coagulopathy (DIC)
WBC, platelets |
|
|
Term
| the APL genes are for what recptor |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| ATRA until Cr/90 days + idarbucin/daunurobucin Days 2,4,6,8 |
|
|
Term
when do you prophylaxis for APL?
what with?
what does this prevent? |
|
Definition
WBC> 10,000
dexamethasone
retenoic acid syndrome |
|
|
Term
| when do you start maint of APL?-2 |
|
Definition
|
|
Term
| how long should you do main tx for APL? |
|
Definition
|
|
Term
| for relapsed APL use what-2 |
|
Definition
| aresenic daily +/- ATRA BID |
|
|
Term
| sx of reinoic acid syndrome-3 |
|
Definition
| fever, peripheral edeam, pleural effusions |
|
|
Term
| tx for reinoic acid syndreom-2 |
|
Definition
|
|
Term
ALL characteriwscs:
median age is-
more males or females?
more commin what ethnicity? |
|
Definition
|
|
Term
| what type fo acute elukemi is leading cause od death < 35 yo |
|
Definition
|
|
Term
| Factros that increase risk fo relapse for ALL-5 |
|
Definition
male
Af AM
WBC> 50k
Age <1, >10
L2,L3
phil chrom |
|
|
Term
| meds invovled in induciton for ALL-4 |
|
Definition
prednisone
vincrisitne
asparagine
daunorubucin |
|
|
Term
| CNS prophylaxis for ALL is best rhu what route? |
|
Definition
|
|
Term
| Tx for CNs prophylaxis of ALL |
|
Definition
|
|
Term
|
Definition
|
|
