Term
cell kill from chemo is lenaear repsonse**
and will evnetually reahc dose limiting toxicity* |
|
Definition
|
|
Term
| *BMT is given for pt to get higher dose of chemo without bone marrow tox spreading to other organs |
|
Definition
|
|
Term
| if dose limit tox (DLT) due to blood elements, what should be given as tx |
|
Definition
|
|
Term
| what cell is respon for producing all blood componetns? |
|
Definition
hematopoeitc stem cell (it goes to myloid progenitor)
(if goes to lympoid then it makes stuff for immune) |
|
|
Term
bone marrow trnasplant is most oftne used in what types of cancers?
also can be for- |
|
Definition
leukemia, lymphomas
solid tumors, bone marrow failure syndrome |
|
|
Term
| source fo stem cells for trnasplant-3 |
|
Definition
bone marrow
peipheral blood
cord blood |
|
|
Term
| bone marrow is removed from where |
|
Definition
|
|
Term
| peripheral blood cells for tnrasplant collected how |
|
Definition
|
|
Term
| rationale for autologus BMT |
|
Definition
| use hgiher dose without meylosuppression effects |
|
|
Term
| rationale for allogenic BMT-4 |
|
Definition
REPLACE CELLS IN APLSTIC ANEMIA
-Rrescue pt with meyloablative therapy
-eridicate abnormal with normal cells
-establish graft vs tumor effect |
|
|
Term
| haploididenitcal fro mismatched sibling or unrelated donor gives less HLA matching |
|
Definition
|
|
Term
| whcih tpye of tnrasplant is where the donor and recipient are different ppl |
|
Definition
|
|
Term
which type of trnasplant has more complicaitons?
however its prefereable for what cnacer |
|
Definition
|
|
Term
| Advantages fo autlogous-3 |
|
Definition
no graft-versus host
-perform in older pts
availability |
|
|
Term
| disadvantge of autologus-2 |
|
Definition
risk of reinfusion disease
no graft vs tumor effect |
|
|
Term
|
Definition
no reinfusion disease
graft vs tumor effect |
|
|
Term
|
Definition
availability
graft vs host |
|
|
Term
| char. of acceptable donor-4 |
|
Definition
| minimal comorb, no malignanices, neg for HIV, Hep, will provide consetn |
|
|
Term
| whcih ages of donors are best for recipeint survivial with tnrasplant |
|
Definition
|
|
Term
| whcih population is worst donor for graft vs host |
|
Definition
|
|
Term
| what is the preffered matached donor |
|
Definition
|
|
Term
| matched donors require match at wha-3 |
|
Definition
|
|
Term
| matched unrelated donor requires- |
|
Definition
| allele match for A, B, C, DR, Dq (10/10) |
|
|
Term
| each sibling only has 25% of being a match* |
|
Definition
|
|
Term
| unrelated amth availbility - |
|
Definition
up to 70% (higher than sibling)
-howeevr not a lot of minorites |
|
|
Term
| HLA/MCH encode for surface markers for immune function |
|
Definition
|
|
Term
Class 1 region HLAs
these are onw hat cells |
|
Definition
|
|
Term
| which HLAS are Class 2 and on immune cells |
|
Definition
|
|
Term
| *the HLAS mentioned have the most polymoprhisms and are most influential* |
|
Definition
|
|
Term
| The conditioning for trnasplant invovles- |
|
Definition
|
|
Term
| goal of PBPC mobilization |
|
Definition
| increase # fo circulating stem cellsto help with peripheral harvest |
|
|
Term
| options for PBPC mobilization in autologus -3 |
|
Definition
meylosuppreive chemo w/ or w/o CSFs
CSFs alone
plerixafor |
|
|
Term
| autologus preperative regimen is used to maximize _ a davoid_ |
|
Definition
|
|
Term
| autologous prep regimens are for what malignancies |
|
Definition
|
|
Term
| the autologous prep regimen invovles- |
|
Definition
| combo of 2-4 drugs (BEAC) |
|
|
Term
allogeneic conditioning therapy :
meylo ablative-2 |
|
Definition
irridation L TBI
high dose chemo- cytoxan, busulfan |
|
|
Term
allogeneic conditioning therapy-
immuno-ablative-3 |
|
Definition
irridaiton
chemo
immunosupprants |
|
|
Term
| look at slide 38 to see the limitng toxicite so drugs used for preparativ regimens* |
|
Definition
|
|
Term
| immediate psot BMT has hgih risk for- |
|
Definition
infeciton (low neutrophils)
bleed (low platelets)
chemo side effect (D/V, liver) |
|
|
Term
| low plateltes lasts 10 day for auto, 2-3 weeks for allogenic |
|
Definition
|
|
Term
| prophylaxis for infeciton is with- |
|
Definition
|
|
Term
| ask someone about the infeciton slides at the end of the lecture |
|
Definition
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|
