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Definition
| Study of health events, disease, distribution, & causes |
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| Filter toxins & return them to plasma |
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| Secretes hormones w/ mature T-cells |
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Largest lymph organ
Stores macrophages |
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Definition
Produce lymphocytes
Airborne pathogens |
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60-80%; half life 4-10 hrs
Stored in marrow, increased release during infection
Early responders to bacerial infection |
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20-30%
NK cells, T-cells, & B-cells
Associated w/ rival infections & adaptive immunity (ability to recognize pathogens & make ABs) |
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1-6%; half life 12 days in tissue
Associated w/ parasitic infections & allergic reactions |
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0-2%; life span only a few days
Associated w/ allergic reactions
Mediators of immediate hypersensitivity response |
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Definition
Immature macrophage
Originate from stem bone marrow
Circulate in blood 3 days then enter tissue to become macrophages |
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Mature monocyte; phagocytosis
Life span months-yrs
Receptors recognize bacteria directly; secrete cytokines |
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Peptide factor released by cells which has inflammatory, growth, & inhibitory functions
Wound healing
Antigen presentation to T-cells for recognition
Promote inflammation & help coordinate activities of other cells |
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Stimulate B-cell function
CD4 protein - T helper cells
CD8 protein - cytotoxic cells ( recognizes foreign antigen & destroys cells) |
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Definition
Can produce ABs
AB receptors in cells wall
Requires T-helper cells to respond appropriately |
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Have no T or B cell marker
Can destroy tumor & virally infected cells w/o previous exposure |
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Small peptides that cause powerful vasodilation
Very active in inflammatory response (increase vascular permeability, vasodialtion, smooth muscle contraction, pain) |
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Major purpose to stop bleeding
Fibrin strands provide an effective barrier to prevent spread of infection |
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| 5 Cardinal Signs of Inflammation |
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Definition
1. Redness - veins dilate & increased permeability leak
2. Swelling - increased proteins = increased water
3. Heat - increased blood flow
4. Pain - bradykinins
5. Loss of function - swelling puts pressure on nerves |
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85% of all antibodies
Antibacterial & antiviral |
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First one produced
Activates complement system |
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Skin & mucous membranes
Saliva, tears, bronchial, GI & GU tract secretions |
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Definition
Lives on B-cell surfaces
Stimulates B-cell growth |
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| Released during immediate hypersensitivity reaction |
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