Term
interferons (IFNs) are what?
mostly produced in resposne to? |
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Definition
cytokines produced by immune system cells
double strnad RNA virus |
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Term
| *all interferons are important for viral infectins and regulating immune |
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Definition
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Term
| 2 types of interfereons and subtypes: |
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Definition
type 1(alpha and beta)
type II (gamma) |
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Term
| majroity of FDA approves interferons are what type? |
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Definition
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Term
| Intron A can be admin how?-4 |
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Definition
| IM, SQ, IV, intra-lesional |
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Term
| I believe IFN-alpha blocks Jack kinase activity, ask someone and look more at slide 7 |
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Definition
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Term
| MOA of IFNs in tumor tx-4 |
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Definition
direct inhibiton of cell prolif
enhance cytotoxic T cell activity
cell cycle regulation
increase surface antigens-> cytotoxicity |
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Term
| what is the main site of catbolism for interferons? |
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Definition
| kindey (so no IFN in urine) |
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Term
| *INF alpha has a lot of unlabeled onco uses (slide 11 |
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Definition
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Term
| IGN alpha can increase risk of what when used with IL-2 |
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Definition
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Term
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Definition
| flu like, depression, fatgiue |
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Term
| what is the most common dose limiting toxicity of IFN alpha |
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Definition
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Term
| Do not use IFN alpha when-4 |
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Definition
preggo/lactating
allergic to IFN a, E coli
autoimmune heptatitis (+ antibody)
newborn/premie |
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Term
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Definition
| cytokin produced by T cells for innate immunity |
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Term
| potency for interluekin is 1.1 mg protein= |
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Definition
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Term
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Definition
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Term
| IL2 recpotr belong to what family? |
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Definition
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Term
| signaling of IL 2 is thru |
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Definition
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Term
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Definition
ehance lymphocte mutogenesis
enhance lymphcyte cytotoxicity
induce lymphokine actiaed and natural activity (LAK and NK)
inducing TNF alpha, IFN gamma |
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Term
| IL-2 exits as covalent/non covalent |
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Definition
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Term
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Definition
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Term
IL-2 has a lot of distribution to-
elimnated thru? |
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Definition
extravascular space
kidneys |
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Term
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Definition
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Term
| due to rapid Cl of IL-2 thru kdineys, what is dosage shceudle like? |
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Definition
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Term
conditions required for using proleukin/IL-2?
when should caution be useD? |
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Definition
normal cardiac and pulmonary
normal thallium stress test but hx of pulm or cardiac disease |
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Term
| IL-2 should be diluted in- |
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Definition
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Term
| IL-2 shoudl be reconsittued, dont shake! |
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Definition
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Term
toxicity for IL2 is lower if bolus or cont?
low/ high dose? |
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Definition
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Term
| what should be monitored in IL 2 |
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Definition
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Term
| IL-2 has interactions wit what nephrotic drugs-2 |
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Definition
aminoglycosides
indomethcin |
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Term
| IL 2 has interactions with what myelotxic meds-1 |
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Definition
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Term
| IL 2 has interacitons with what cardiotoxic drugs=1 |
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Definition
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Term
| IL 2 has interacitons with what hepatox drugs-2 |
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Definition
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Term
what meds reduce IL2 side effects?
however they also reduce _ so should be avoided? |
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Definition
glucorticosteroids
anti tumor effiacy |
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Term
| IL-2 is assoicated with causing- 3 |
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Definition
neutrophil funct decrease
sepsis/ endocarditis
capillary leak syndrome |
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Term
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Definition
hypotension
pulmnary congestion
anemia thombocytopenia, capillary leak syndrome |
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