Term
definition:
produced from a single B lymphocyte |
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Definition
| monoclonal aantibod (mAbs) |
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Term
def:
antibodies derived from mice thru fusion of mouse myeloma and B cells |
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Definition
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Term
def:
antibodies constructed from variable regions of murine source and constant regions from a human source |
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Definition
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Term
def:
antibody constructed with only antigen binding regions from a mouse and the remainder from human source |
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Definition
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Term
def:
antibody entirely from human source |
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Definition
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Term
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Definition
mAb dedpent cell mediated cytotoxicity
block intracell onco signaling pathways |
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Term
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Definition
| complement depend cytotxicity |
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Term
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Definition
| direct induciton of cell apopt |
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Term
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Definition
| down reg of recpt and inhib of recpt activation |
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Term
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Definition
| deliver drugs, toxins, and radioisptopes to cancer cells |
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Term
| trastuzumab is specific to whcih EGFR tumor- |
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Definition
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Term
| trastuzumab emtansine is specific to which EGFR tumor- |
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Definition
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Term
| cetuximab is specific to which EGFR tumor |
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Definition
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Term
| suffix zu is for what kind of mAB |
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Definition
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Term
| suffix o is a def for which mAB |
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Definition
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Term
| suffix u is def for which mAB |
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Definition
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Term
| suffix xi is a def initon for whihc mAB |
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Definition
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Term
Herceptin is what kind of mAB?
who produces it? |
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Definition
recombinant, humazined mouse
Genentech |
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Term
| trastuzumab is used inadjuvant breast cancer, what are the 2 regimens |
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Definition
combo with doxi and cyclophosphamide
single agent for node neg |
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Term
| trastuzumab is used for metastatic breast cancer, what are the 2 therapies: |
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Definition
combo with paclitaxel
single agent |
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Term
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Definition
cardiomyopathy
infusion rxn
pulmonary
neutropenia |
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Term
| doses and admin of trnaszumab are on word doc |
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Definition
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Term
Kadcyla is what kind of mAB?
what is it conjugated with? |
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Definition
reomcbinant humazined
maytansinoid (DM1/ antibody drug conjugate) |
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Term
| is Kadcyla also specific fr Her2 ? |
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Definition
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Term
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Definition
IV
injection
100 mg per vial |
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Term
indicaiton for kadcyla
combo or single agent? |
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Definition
Her2 positive metastatic breast prev tx with trastuzumab AND taxane;
either |
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Term
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Definition
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Term
| cetuximab is what kind of mAB? |
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Definition
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Term
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Definition
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Term
| cetuximab after binding to EGFR inhibits-3 |
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Definition
tGf alpha
cell growth
VEGF profuciton |
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Term
cetuximab used in colorectal cancer can be used as single or combo?
if combo what agent is it with |
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Definition
either signle ro combo
combo with irinotecan |
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Term
| common ADEs of cetuximab- (incidence is 25%)-3 |
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Definition
| cutaneus, headache, diarrhea |
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Term
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Definition
| infusion, cardiopulmonary arrest, derm (limit sun exposure), pulmonary |
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Term
| cetuximab is premedicated with |
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Definition
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Term
| cetuximab is given 1 wk prior to? |
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Definition
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Term
| you reduce infusion rate by _ % for Grade 1 or 2 infusion rxns and non serious Grade 3-4 (p;ermantly d/c if serious rxn) |
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Definition
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Term
| when do you withold infusion of cetuximab |
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Definition
| severe presistant acne rash |
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Term
Vectibix is what kind of antibody?
what is it specific for? |
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Definition
fully human monoclonal anb
EGFR |
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Term
| indication for panitumumab |
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Definition
| metastatic colorectal carcinoma w/o KRAS mutation |
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Term
| panitumab dosing is on word doc |
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Definition
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Term
| whcih med i not reccomended for combo with chemotherapy duet o increase toxicites? |
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Definition
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Term
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Definition
common (skin, moslty)
derm (limit sun exposure)
infusion
pulmonary |
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Term
| what do you monitor for in panitumam- |
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Definition
| electrolytes unitl 8 wks after completion |
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Term
| what is the antibody specific for VEGF? |
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Definition
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Term
| what kind of antobody is bevacizumab |
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Definition
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Term
| * ask someone if we need to know the vial forms for all the drugs |
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Definition
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Term
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Definition
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Term
which drug prevents new blood vessel formation?
how? |
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Definition
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Term
| indicaitons for bevicizumab-4 |
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Definition
metastatic colorectal
nonsquamous non small cell lung
glioblastoma
metaststic renal carcnimoa |
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Term
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Definition
| GI, wound healing complicaion, hemorrhage, common (pain, HT) |
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Term
| dont admin bevcixumab as- |
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Definition
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Term
| do not initate cbevcixumab for 28 days following-2 |
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Definition
surgical wound healing
major surgery |
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Term
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Definition
non GI fistual
thomboembolic
nephrotic syndrome
uncontrolled HTN |
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Term
| antibodies specific to CD20?-2 |
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Definition
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Term
| rituxumab is what kind of antibody |
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Definition
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Term
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Definition
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Term
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Definition
INFUSION
TUMOR LYSIS SYNDROME (renal fail, hyperK, hypoC)
mucotaneous rxns
multifocal leukoenceph |
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Term
| premedicate pt before ritxumab with-2 |
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Definition
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Term
dosing for ritiuxumab-
first tx for relapsed nonhodkins |
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Definition
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Term
dosing for ritiuxumab-
for all non higkinds lymphomas |
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Definition
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Term
dosing for ritiuxumab-
retreating relapsed nonhodkins |
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Definition
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Term
dosing for ritiuxumab-
previusly untreated NHL |
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Definition
| on day 1 of each CVP chemo for 8 doses |
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Term
dosing for ritiuxumab-
non pregoressing NHL |
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Definition
| follow CVP, 6 month intervals |
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Term
dosing for ritiuxumab-
diffuse large b cell NHL |
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Definition
| on day 1 of each chemp cycle fro 8 times |
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Term
| premedicate ofatunimab wiht-3 |
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Definition
APAP
antihistamine
corticosteroid |
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Term
| ofatumumab is what kind of antibodu? |
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Definition
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Term
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Definition
| infusion, cytopenia, PML, hep b reactivation |
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Term
ibritumomab is what kind of antibody?
conjugated with? |
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Definition
murine IgG
indium or yttrium |
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Term
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Definition
| CD20, apooptosis by ofrmaiton of free radicals |
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Term
| indicaitons for ibritumomab-2 |
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Definition
refractory NHL
ritixumab refractory NHL |
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Term
| when considering toxiciites of ibritumomab must also consider what other toxicites? |
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Definition
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Term
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Definition
infusion,
cytopenia,
hematologic
cuteanous |
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Term
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Definition
CYTOPENIA (70%)
ANAPHYLAXIS
HYPOTHYROIDISM |
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Term
| antibidoie specific to CD52? |
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Definition
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Term
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Definition
cytopenia
infusion
infection |
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Term
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Definition
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