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Exam 2
Lecture 1- antibodies
76
Archaeology
3rd Grade
02/09/2014

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Term
definition:
produced from a single B lymphocyte
Definition
monoclonal aantibod (mAbs)
Term
def:
antibodies derived from mice thru fusion of mouse myeloma and B cells
Definition
murine mAbs
Term
def:
antibodies constructed from variable regions of murine source and constant regions from a human source
Definition
chimeric mAbs
Term
def:
antibody constructed with only antigen binding regions from a mouse and the remainder from human source
Definition
humanized mAbs
Term
def:
antibody entirely from human source
Definition
human mAbs
Term
MOA of trastuzumab: 2
Definition
mAb dedpent cell mediated cytotoxicity
block intracell onco signaling pathways
Term
MOA of rituximab:
Definition
complement depend cytotxicity
Term
MOA of cetuximab:
Definition
direct induciton of cell apopt
Term
MOA of bevacizumab
Definition
down reg of recpt and inhib of recpt activation
Term
MOA of tositumomab I 131
Definition
deliver drugs, toxins, and radioisptopes to cancer cells
Term
trastuzumab is specific to whcih EGFR tumor-
Definition
Her2
Term
trastuzumab emtansine is specific to which EGFR tumor-
Definition
Her2
Term
cetuximab is specific to which EGFR tumor
Definition
EGFR
Term
suffix zu is for what kind of mAB
Definition
humainzed
Term
suffix o is a def for which mAB
Definition
mouse
Term
suffix u is def for which mAB
Definition
fully human
Term
suffix xi is a def initon for whihc mAB
Definition
chimeric
Term
Herceptin is what kind of mAB?
who produces it?
Definition
recombinant, humazined mouse
Genentech
Term
trastuzumab is used inadjuvant breast cancer, what are the 2 regimens
Definition
combo with doxi and cyclophosphamide
single agent for node neg
Term
trastuzumab is used for metastatic breast cancer, what are the 2 therapies:
Definition
combo with paclitaxel
single agent
Term
ADEs of transtuzumab:4
Definition
cardiomyopathy
infusion rxn
pulmonary
neutropenia
Term
doses and admin of trnaszumab are on word doc
Definition
Term
Kadcyla is what kind of mAB?
what is it conjugated with?
Definition
reomcbinant humazined
maytansinoid (DM1/ antibody drug conjugate)
Term
is Kadcyla also specific fr Her2 ?
Definition
yes!
Term
admin of Kadcyla?-2
dose?
Definition
IV
injection
100 mg per vial
Term
indicaiton for kadcyla
combo or single agent?
Definition
Her2 positive metastatic breast prev tx with trastuzumab AND taxane;
either
Term
toxicites of Kadcyla-3
Definition
cardiac
hepatic
fetal
Term
cetuximab is what kind of mAB?
Definition
chimeric
Term
half life of cetuximab
Definition
112 hrs
Term
cetuximab after binding to EGFR inhibits-3
Definition
tGf alpha
cell growth
VEGF profuciton
Term
cetuximab used in colorectal cancer can be used as single or combo?
if combo what agent is it with
Definition
either signle ro combo
combo with irinotecan
Term
common ADEs of cetuximab- (incidence is 25%)-3
Definition
cutaneus, headache, diarrhea
Term
severe ADEs of cetuximab
Definition
infusion, cardiopulmonary arrest, derm (limit sun exposure), pulmonary
Term
cetuximab is premedicated with
Definition
H1 antagonist
Term
cetuximab is given 1 wk prior to?
Definition
radioation therap
Term
you reduce infusion rate by _ % for Grade 1 or 2 infusion rxns and non serious Grade 3-4 (p;ermantly d/c if serious rxn)
Definition
50%
Term
when do you withold infusion of cetuximab
Definition
severe presistant acne rash
Term
Vectibix is what kind of antibody?
what is it specific for?
Definition
fully human monoclonal anb
EGFR
Term
indication for panitumumab
Definition
metastatic colorectal carcinoma w/o KRAS mutation
Term
panitumab dosing is on word doc
Definition
Term
whcih med i not reccomended for combo with chemotherapy duet o increase toxicites?
Definition
panitumumab
Term
ADes of panitumumab-4
Definition
common (skin, moslty)
derm (limit sun exposure)
infusion
pulmonary
Term
what do you monitor for in panitumam-
Definition
electrolytes unitl 8 wks after completion
Term
what is the antibody specific for VEGF?
Definition
bevacizumab
Term
what kind of antobody is bevacizumab
Definition
humnized mouse
Term
* ask someone if we need to know the vial forms for all the drugs
Definition
Term
half life of bevacizumab
Definition
20 days`
Term
which drug prevents new blood vessel formation?
how?
Definition
bevicizumab
blocks VEGF
Term
indicaitons for bevicizumab-4
Definition
metastatic colorectal
nonsquamous non small cell lung
glioblastoma
metaststic renal carcnimoa
Term
ADes of bevcixumab-4
Definition
GI, wound healing complicaion, hemorrhage, common (pain, HT)
Term
dont admin bevcixumab as-
Definition
IV push/bolus
Term
do not initate cbevcixumab for 28 days following-2
Definition
surgical wound healing
major surgery
Term
d/c bevcixumab if-4
Definition
non GI fistual
thomboembolic
nephrotic syndrome
uncontrolled HTN
Term
antibodies specific to CD20?-2
Definition
rituxumab
ofatumumab
Term
rituxumab is what kind of antibody
Definition
chimeric
Term
indicaiotn for ritixumab
Definition
non hidgkins lymphoma
Term
ADes of rituxumab-4
Definition
INFUSION
TUMOR LYSIS SYNDROME (renal fail, hyperK, hypoC)
mucotaneous rxns
multifocal leukoenceph
Term
premedicate pt before ritxumab with-2
Definition
APAP
antihistamine
Term
dosing for ritiuxumab-
first tx for relapsed nonhodkins
Definition
1 q wk for 4-8 doses
Term
dosing for ritiuxumab-
for all non higkinds lymphomas
Definition
375 mg/m2
Term
dosing for ritiuxumab-
retreating relapsed nonhodkins
Definition
every week for 4 doses
Term
dosing for ritiuxumab-
previusly untreated NHL
Definition
on day 1 of each CVP chemo for 8 doses
Term
dosing for ritiuxumab-
non pregoressing NHL
Definition
follow CVP, 6 month intervals
Term
dosing for ritiuxumab-
diffuse large b cell NHL
Definition
on day 1 of each chemp cycle fro 8 times
Term
premedicate ofatunimab wiht-3
Definition
APAP
antihistamine
corticosteroid
Term
ofatumumab is what kind of antibodu?
Definition
human monoclonal
Term
ADEs of ofatumumab- 4
Definition
infusion, cytopenia, PML, hep b reactivation
Term
ibritumomab is what kind of antibody?
conjugated with?
Definition
murine IgG
indium or yttrium
Term
MOA of ibritiumab
Definition
CD20, apooptosis by ofrmaiton of free radicals
Term
indicaitons for ibritumomab-2
Definition
refractory NHL
ritixumab refractory NHL
Term
when considering toxiciites of ibritumomab must also consider what other toxicites?
Definition
ritixumab!!!!
Term
ADe sof ibritumomab
Definition
infusion,
cytopenia,
hematologic
cuteanous
Term
Ades of tositumab I131-3
Definition
CYTOPENIA (70%)
ANAPHYLAXIS
HYPOTHYROIDISM
Term
antibidoie specific to CD52?
Definition
alemtuxumab
Term
ADes fo alemtuxumab-3
Definition
cytopenia
infusion
infection
Term
premed alemtuxumab with?
Definition
APAP
diphenhydramine
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